CAS: 138008-97-6; (2-Isopropoxyphenyl)Boronic Acid

该化合物是一种有机有机体化合物,其特征特征是附在一个苯环上的碱性功能组,该化合物还被一个异丙氧基组所取代.该化合物通常具有与黄酸相同的特性,例如能够形成含有二醇的可逆复合物,使其在各种应用中有用,包括有机合成和药用化学.异丙氧组可增强有机溶剂中的溶性,并可能影响其再活性和稳定性.2-异丙氧苯丙胺常被用于铃木-米亚乌拉交叉组合反应,这是形成碳-碳联结的关键.此外,该化合物的碱性酸会参与形成丙烯酯酯,进一步扩大其在合成途径中的效用.该化合物的处理通常受到谨慎的处理,因为氧化酸具有潜在的再活性,特别是在有水能的情况下,可导致水解.

结构式图片

相似化合物

213211-69-9 480438-71-9 1266379-28-5

物理性质

MSDS等安全信息

欧盟法规

C&L通报

上下游产品

CAS号701-07-5 1-溴-2-异丙氧基苯

合成工艺路线路线简述

    📜1-溴-2-异丙氧基苯置于正丁基锂,硼酸三甲酯,盐酸体系中,用 四氢呋喃,正己烷 用作溶剂,化学反应 2.25H,以70%的收率获得2-异丙氧基苯硼酸
    参考文献:Suzuki Cross-Coupling Reaction Of Sterically Hindered Aryl Boronates With 3-Iodo-4-Methoxybenzoic Acid Methylester
    标题:Suzuki Cross-Coupling Reaction Of Sterically Hindered Aryl Boronates With 3-Iodo-4-Methoxybenzoic Acid Methylester
    摘要:The Cross-Coupling Reaction Of 3-Iodo-4-Methoxybenzoic Acid Methylester With Sterically Hindered Arylboronic Esters And Especially 5,5-Dimethyl-2-Mesityl-1,3,2-Dioxaborinane,Is Reported. The Optimisation Of The Process In Order To Obtain Biaryls In Good Yield By Using Anhydrous Benzene At Reflux And Sodium Phenoxide In The Presence Of 0.06 Equiv. Of Pd(Pph3)(4) Is Described. (C) 2000 Elsevier Science Ltd. All Rights Reserved.
    Doi:10.1016/s0040-4020(00)00928-5

    海关参考信息

    专利信息


    专利号:EP-1836163-B1
    优先权日:2004-12-23
    标题 :Pyrrolidine derivatives for the treatment of a disease depending on the activity of renin
    发明人：BREITENSTEIN WERNER; COTTENS SYLVAIN; EHRHARDT CLAUS; JACOBY EDGAR; LORTHIOIS EDWIGE LILIANE JEANNE; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; SELLNER HOLGER; SIMIC OLIVER
    权利人:NOVARTIS AG
    摘要:Novel 3-mono-, 3,4-di- and 3,4,4,-tri-substituted pyrrolidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on inappropriate activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on inappropriate activity of renin; the use of a compound of that class in the treatment of a disease that depends on inappropriate activity of renin; pharmaceutical formulations comprising a said substituted pyrrolidine compound, and/or a method of treatment comprising administering a said substituted pyrrolidine compound, a method for the manufacture of said substituted pyrrolidine compounds, and novel intermediates and partial steps for their synthesis are described. The substituted pyrrolidine compounds are especially of the formula I wherein the substituents are as described in the specification.

    其他信息查阅

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    实用工具

    ⚠️全国化工行业净网倡议书
    📋制造商识别码
    📖 海关编码查询
    📝MSDS生成器

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献

    参考DOI号:10.1016/S0040-4020(00)00928-5
    📝 需求与反馈
    尽可能描述清楚需求与问题信息
    ×

    通知