CAS: 13336-31-7; 4-Methoxy-2,3-Dihydro-1H-Inden-1-One

相似化合物

67199-57-9 52428-09-8 34985-41-6

上下游产品

4-羟基-1-茚酮 4-Hydroxy-2,3-Dihydroindan-1-One 40731-98-4
1-氧代-2,3-二氢-1H-茚-4-苯甲酸盐 4-(Benzyloxy)-1-Indanone 59725-61-0
4-Methoxyindan-1-Ol 67199-57-9

📜氢化肉桂酸内酯置于三氯化铝,Potassium Carbonate,Sodium Chloride体系中,用 丙酮 用作溶剂,化学反应 3.5H,反应生成4-甲氧基-1-茚酮
参考文献:异普瑞霉素的全合成:增强的重氮离子特性和对癌细胞的生长抑制活性的结构证据.
标题:异普瑞霉素的全合成:增强的重氮离子特性和对癌细胞的生长抑制活性的结构证据.
摘要:使用溴化ab环合成子与代表d环的硼酸酯的suzuki偶联,然后进行阴离子环化和适当的官能团处理,首次合成了结构新颖的重氮苯并[a]芴类抗生素异普瑞霉素(ipk).提供了重氮苯并[a]芴体系表现出体外抗癌活性的第一个迹象,并描述了由于分子内氢键作用而增强重氮离子特性的x射线晶体学证据.
Doi:10.1021/ol0712374

专利信息

专利号:WO-9845272-A1
优先权日:1997-04-07
标题:Topoisomerase inhibitors
发明人：DEADY LESLIE WILLIAM; DENNY WILLIAM ALEXANDER; KAYE ANTHONY JAMES
权利人:UNIV LATROBE; DEADY LESLIE WILLIAM; DENNY WILLIAM ALEXANDER; KAYE ANTHONY JAMES
摘要:The invention provides a novel series of tetracyclic quinoline and quinoxaline carboxamides, bis compounds in which two of the tetracyclic compounds are joined by a linker, and pharmaceutically-acceptable salts and N-oxides thereof, which have the ability to inhibit topoisomerase activity. The compounds are active in vitro and in vivo against tumour cells. Methods of synthesis and pharmaceutical compositions are also claimed.

专利号:US-5098925-A
优先权日:1990-02-08
标题:Spiro-dihydroisoindole compounds
发明人：BARE THOMAS M
权利人:ICI AMERICA INC
摘要:The present invention relates to spiroisoindolines that are antagonists at the phencyclidine receptor of the N-methyl-D-aspartate receptor complex and which are useful when such antagonism is desired such as in the treatment of neurological disorders. The invention further provides processes for preparing the spiroisoindolines, intermediates useful for their synthesis, pharmaceutical compositions containing them, and methods for their use.

专利号:CN-116283657-A
优先权日:2023-02-22
标题 :A kind of indanone derivative and its synthesis method and application