CAS: 127-42-4; (+)-α-Methylionone

该化合物是一个不饱和且具有独特的结构框架的不饱和的基酮,其结构框架以环球为特征,具有环球和扩展的同化系统.其定义明确的立体化学和硬性环有助于其在不对称合成和发相应用中的稳定性和潜在效用.α, α-饱和碳基组增强了再活动,使其成为有机转化中有价值的中间体,包括迈克尔添加物和循环反应物. 三甲基替代环球核心在催化工艺中具有抑制力,影响选择性. 该复合体的结构特征使其适合对精密的分子设计至关重要的精细化学和口味/芳香开发进行研究.

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相似化合物

127-51-5 1335-46-2 79-78-7

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

3-(2',6',6'-Trimethylcyclohex-2'-En-1'-yl)Prop-2-Enal 51768-83-3
3-(2,6,6-Trimethyl-2-Cyclohexen-1-yl)-2-Propenoic Acid 37384-69-3
(E)-3-(2,6,6-Trimethylcyclohex-2-Enyl)Prop-2-En-1-Ol 51768-75-3
(E)-1-(2,2-Dimethyl-6-Methylenecyclohexyl)Pent-1-En-3-One 1094742-87-6
Ethyl 3-(2,6,6-Trimethyl-2-Cyclohexenyl)-2-Propenoate 126456-65-3
(E)-1-(2,6,6-Trimethylcyclohex-2-Enyl)Pent-1-En-3-Ol 436099-50-2

合成工艺路线路线简述

    📜3-(2',6',6'-Trimethylcyclohex-2'-En-1'-yl)Prop-2-Enal置于吡啶,Manganese(Iv) Oxide,氢氧化钾,Lipase Ps,Magnesium体系中,用 甲醇,乙醚,二氯甲烷 用作溶剂,化学反应 29.0H,反应生成Alpha-甲基紫罗兰酮
    参考文献:The Enantiomers Of Iralia®: Preparation And Odour Evaluation
    标题:The Enantiomers Of Iralia®: Preparation And Odour Evaluation
    摘要:The Enantiomers Of Methyl Ionones 1 And 2 Were Prepared By An Enzyme-Catalysed Approach. Their Odour Properties Were Evaluated By Skilful Perfumers. (C) 2007 Elsevier Ltd. All Rights Reserved.
    Doi:10.1016/j.Tetasy.2007.04.022

    海关参考信息

    专利信息


    专利号:US-2024240209-A1
    优先权日:2021-04-20
    标 题:Synthesis of enantiopure cis-a-irone from a renewable carbon source
    发明人:CHEN XIXIAN; ZHANG CONGQIANG; T REHKA; SHUKAL SUDHA; SMITH DEREK; ANDRÉ ISABELLE; JEREMY ESQUE
    权利人:AGENCY SCIENCE TECH & RES; INSTITUT NATIONAL DE RECH POUR L AGRICULTURE LALIMENTATION ET LENVIRONMENT; CENTRE NAT RECH SCIENT; INSTITUT NAT DES SCIENCES APPLIQUEES DE TOULOUSE
    摘要:Synthesis of enantiopure cis-α-irone from a renewable carbon source Disclosed herein are natural and synthetic enzymes capable of performing a method of producing cis-α-irone. The method comprises providing an enzyme capable of converting psi-ionone to cis-α-irone; and contacting the enzyme and psi-ionone under suitable conditions to produce cis-α-irone. The enzyme may be a methyltransferase from Streptomyces albireticuli (SaMT), a promiscuous bifunctional methyltransferase/cyclase (pMT1) enzyme from Streptomyces, or a modified pMT1 enzyme with at least one substitution. The enzymes allow the in-vivo and in-vitro production of cis-α-irone including the use of glucose as feedstock for the biotransformation into cis-α-irone.

    专利号:CN-108997096-A
    优先权日:2018-07-27
    标 题:A method for the synthesis of citral by highly selective oxidation of geraniol

    专利号:WO-8911536-A1
    优先权日:1988-05-27
    标题:Microbial biocatalyst for production of terpenic aldehydes
    发明人:DAVIS KAREN JOHANNA; BEST DAVID JOHN; BURFIELD ANTHONY GRAHAM; TAYLOR FRANK; TALBOT JANE STELLA
    权利人:NOVALAL LTD
    摘要:An active biocatalyst for converting alpha-pinene epoxide to terpenic aldehydes useful in perfumery, e.g. formula (I), is produced by growing a microorganism, preferably Pseudomonas fluorescens NCIB 40043, to late log phase in a medium containing carbohydrate (e.g. glucose) as the carbon source, and adding alpha-pinene. The resulting culture comprises active biocatalyst which is brought into contact with alpha-pinene epoxide for aldehyde synthesis.

    专利号:US-4271046-A
    优先权日:1978-10-12
    标 题:Novel norcamphanyl-substituted pyrans, method for their synthesis and use thereof in perfumery
    发明人:WILLIS BRIAN J; DITTRICK JOHN W
    权利人:FRITZSCHE DODGE & OLCOTT INC
    摘要:Norcamphanyl-substituted pyrans, their preparation and their use as olfactory components of perfume formulations are disclosed.

    专利号:US-3647479-A
    优先权日:1969-10-28
    标 题 :Method of flavoring food by addition of benzoxepin-3-ones and benzodioxepin-3-ones
    发明人:BEEREBOOM JOHN J; CAMERON DONALD P; STEPHENS CHARLES R
    权利人:PLIZER INC
    摘要:Benzoxepin-3-ones and Benzodioxepin-3-ones, prepared by a novel synthesis, are useful as flavor and odorant agents for foods and perfumes respectively to impart a watermelonlike taste and odor.

    专利号:US-4197246-A
    优先权日:1978-10-12
    标 题 :Novel norcamphanyl-substituted pyrans, method for their synthesis and use thereof in perfumery
    发明人:DITTRICK JOHN W; WILLIS BRIAN J
    权利人:FRITZSCHE DODGE & OLCOTT INC
    摘要:Norcamphanyl-substituted pyrans, their preparation and their use as olfactory components of perfume formulations are disclosed.

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    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    参考标题:Synthesis, Olfactory Evaluation And Determination Of The Absolute Configuration Of The β- And γ-Iralia® Isomers
    作者:Assem Barakat,Elisabetta Brenna,Claudio Fuganti,Stefano Serra |发布日期:2008.10
    摘要:Synthesis Of The Methyl-Ionone Isomers 6-9 Is Described. The Enantiomers Of The γ-Isomers 8 And 9 Are Prepared By Enzyme-Mediated Resolution Of The Corresponding 4-Hydroxy Derivatives Followed By Reductive Elimination Of The Hydroxy Group. The Absolute Configuration Of The Latter Compound Is Determined By Chemical Correlation With The Known α-Isomers. Since All The Isomers Obtained Are Components Of The

    合成参考文献


    摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
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