CAS: 116355-84-1; (2R,2'R)-2,2'-((((5R,6R,7S,9S,16R,18S,19S)-19-Amino-16,18-Dihydroxy-5,9-Dimethylicosane-6,7-Diyl)Bis(Oxy))Bis(2-Oxoethane-2,1-Diyl))Disuccinic Acid

该化合物是一种该化合物是一种结构仿真Fumonisiin B1,但因缺少一个氢氧基化合物组而不同.它作为次要代谢物,污染玉米等作物,并因其抑制性影响对人和动物健康构成危险.Fummonisin B2 被用于研究,作为甲型六氯环己烷分析的参考标准,从而得以准确检测和量化食物和饲料样品.它的稳定性和精密特性使得它对于毒理学研究,方法验证和监管合规测试具有价值.适当处理由于其危险性质至关重要.

结构式图片

欧盟法规

C&L通报REACH预注册

合成工艺路线路线简述

    (R)-3-Benzyloxycarbonyl-Pentanedioic Acid Benzyl Ester (Z)-(1R,2S,4S,11R,13S,14S)-11,13-Bis-Benzyloxy-2-((R)-3,4-Bis-Benzyloxycarbonyl-Butyryloxy)-14-Dibenzylamino-4-Methyl-1-((R)-1-Methyl-Pentyl)-Pentadec-6-Enyl Ester置于palladium Dihydroxide 盐酸,氢气体系中,用 四氢呋喃,叔丁醇 用作溶剂,以60%的收率获得聚乙二醇b2
    参考文献:Enantioselective Total Synthesis Of Fumonisin B2
    标题:Enantioselective Total Synthesis Of Fumonisin B2
    摘要:
    Doi:10.1021/jo9711347

    海关参考信息

    专利信息


    专利号:US-2025147014-A1
    优先权日:2022-02-14
    标题:Plasmon-enhanced fluorescence biochemical sensors
    发明人:PINCHUK ANATOLI; SERGEYEVA TETYANA; YARYNKA DARIA; CHEGEL VLADIMIR; LOPATYNSKYI ANDRI
    权利人:UNIV COLORADO REGENTS; THE REGENTS OF THE UNIV OF COLORADO A BODY
    摘要:A highly sensitive technology enabling selective recognition of aflatoxins such as in contaminated cereal samples. Methods for the synthesis of AgNP-containing MIP membranes from the monomer mixtures containing both methacrylate monomers and oligomers as well as AgNOs solution in dimethylformamide enable the detection system. The AgNP were formed in the structure of the polymeric membranes during the pre-heating step followed by the UV-initiated polymerization. The highly selective sensor elements where MIP membranes are combined with the Ag nanostructures as signal amplifiers (LSPR-MIP nanochips) can be stored separately and used with a simple optical recognition system as selective elements of point-of-care sensor devices, even in in-field conditions. Composite plasmonic membranes provide both highly selective recognition of the target toxin and the generation of an enhanced optical signal, allowing aflatoxin B1 detection at ultralow concentrations.

    专利号:US-10287592-B2
    优先权日:2014-02-07
    标 题:Bacillus host
    发明人:VAN RIJ EVERT TJEERD; SPAANS MARTINE; HILLEBRAND HENDRIKUS BERNARDUS CAROLUS
    权利人:DSM IP ASSETS BV
    摘要:The invention provides Bacillus host cell deficient in the production of a neutral protease and of a alkaline protease which host cell comprises a nucleic acid construct, wherein the nucleic acid construct comprises a polynucleotide encoding a compound of interest or encoding a compound involved in the synthesis of a compound of interest operably linked to a promoter sequence allowing for expression of the polynucleotide in the host cell, wherein the promoter comprises a bacteriophage promoter sequence, more preferably a bacteriophage SPO1 promoter sequence. Said host cell can advantageously be used in a method of production of a compound of interest.
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    主要参考文献


    1: Gherbawy Y, Elhariry H, Kocsubé S, Bahobial A, Deeb BE, Altalhi A, Varga J, Vágvölgyi C. Molecular characterization of black Aspergillus species from onion and their potential for ochratoxin A and fumonisin B2 production. Foodborne Pathog Dis. 2015 May;12(5):414-23. doi: 10.1089/fpd.2014.1870. Epub 2015 Feb 25. doi: 10.1080/19440049.2014.976846. Epub 2014 Nov 6. doi: 10.1080/19393210.2013.819816. Epub 2013 Aug 1. Chinese. Chinese. doi: 10.1016/j.fct.2016.10.013. Epub 2016 Oct 13. doi: 10.1016/j.foodchem.2015.07.059. Epub 2015 Jul 14. doi: 10.1007/s12550-013-0172-0. Epub 2013 Jun 27. doi: 10.1007/s10295-010-0916-1. Epub 2010 Dec 4. doi: 10.1080/19440049.2015.1124459. Epub 2015 Dec 24. doi: 10.1080/19440049.2013.796594. Epub 2013 Jun 14. doi: 10.1002/rcm.7374. doi: 10.1016/j.autneu.2014.08.001. Epub 2014 Aug 20. doi: 10.4315/0362-028X.JFP-13-149. doi: 10.3390/toxins7020582.
    16: Xie TT, Qiu F, Yang MH, Qi AD. [Simultaneous determination of fumonisins B1 and B2 in traditional Chinese medicines by high-performance liquid chromatography-tandem mass spectrometry]. Yao Xue Xue Bao. 2011 Jul;46(7):822-7. Chinese. doi: 10.1021/jf902834g. doi: 10.3390/toxins6082580.
    19: Martins HM, Almeida IF, Camacho CR, Santos SM, Costa JM, Bernardo FM. Occurrence of fumonisins in feed for swine and horses. Rev Iberoam Micol. 2012 Jul-Sep;29(3):175-7. doi: 10.1016/j.riam.2011.07.005. Epub 2011 Aug 11.

    合成参考文献


    参考文献:10.3382/ps.2011-01434
    摘要:Benlashehr I, Repussard C, Jouglar JY, Tardieu D, Guerre P. Toxicokinetics of fumonisin B2 in ducks and turkeys. Poult Sci. 2011 Aug;90(8):1671–5. doi: 10.3382/ps.2011-01434.
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