CAS: 92812-82-3; (S)-2-Amino-3-(2-(Fluoro-18F)-4,5-Dihydroxyphenyl)Propanoic Acid

相似化合物

75290-51-6 154051-94-2 102034-49-1

上下游产品

6-<(18)F>Fluoro-L-Dopa 92812-82-3
左旋多巴 Levodopa 59-92-7
N-(Tert-Butoxycarbonyl)-3,4-Di(Tert-Butoxycarbonyloxy)-6-[18F]Fluoro-L-Phenylalanine Methyl Ester 1421282-70-3
Tert-Butyl (2S)-2-(Benzhydrylideneamino)-3-(2-(18F)Fluoranyl-4,5-Dimethoxyphenyl)Propanoate 491862-95-4
Methyl (2S)-3-[2-(18F)Fluoranyl-4,5-Bis[(2-Methylpropan-2-yl)Oxycarbonyloxy]Phenyl]-2-[(2-Methylpropan-2-yl)Oxycarbonylamino]Propanoate 1403599-75-6

📜(18)F-2,5-Dihydro-3,6-Dimethoxy-2-Isopropyl-5-(2'-Fluoro-4'-Methoxybenzyl)-(2R,5S)-Pyrazine-5'-Formate置于氢碘酸,Sodium Hydroxide体系中,用 二氯甲烷,水 作为反应溶剂,化学反应生成 氟多巴
参考文献: Nucleophilic Fluorination Of Aromatic Compounds[fr] Fluoration Nucléophile De Composés Aromatiques
标题: Nucleophilic Fluorination Of Aromatic Compounds[fr] Fluoration Nucléophile De Composés Aromatiques

专利信息

专利号:US-10675366-B2
优先权日:2016-08-12
标 题 :Imaging tumor glycolysis by non-invasive measurement of pyruvate kinase M2
发明人：BEINAT CORRINE GAYE; ALAM ISRAT SHAMIMA; JAMES MICHELLE L; GAMBHIR SANJIV S; SRINIVASAN ANANTH
权利人:UNIV LELAND STANFORD JUNIOR
摘要:The present disclosure provides a positron emission tomography (PET)-detectable 1-((2-fluoro-6-[18F]fluorophenyl)sulfonyl)-4-((4-methoxyphenyl)sulfonyl)piperazine ([18F]DASA-23) probe that can selectively bind to the pyruvate kinase variant M2 (PKM2) found in cancer cells, such as of human glioma. Given the importance of PKM2 in the regulation of tumor metabolism, there is an on-going need to non-invasively measure its expression through the development of PKM2-specific radiopharmaceuticals. Precursors useful for the synthesis of the radiolabeled [18F]DASA-23-PKM2-specific probe and related compounds, and their methods of synthesis, are provided. Since the half-life of the 18F isotope is approximately 110 min, it is advantageous for a practitioner to attach the radionuclide to the precursor shortly before administration. Therefore, a precursor compound suitable for receiving the radionuclide and capable of specifically binding to the PKM2 variant can be provided.

专利号:US-11820790-B2
优先权日:2015-05-20
标 题 :Device and cassette for performing a plurality of synthesis processes of preparing a radiopharmaceutical in series
发明人：TADINO VINCENT LUC ANTOINE; VILLERET GUILLAUME ANDRÉ RENÉ
权利人:OUT AND OUT CHEMISTRY S P R L
摘要:A cassette for performing a plurality of synthesis processes of preparing a radiopharmaceutical in series in a synthesizer, includes: at least one manifold provided with a plurality of valves connectable to and operable by the synthesizer; an anion-exchanger comprising an anionic exchange material; an eluent container comprising an eluent; and a recondition container comprising a reconditioning agent.

专利号:US-12208372-B2
优先权日:2016-12-21
标题:Solid phase conditioning
发明人：VERBRUGGE NICOLAS; FRANCI XAVIER Y A; THAWINWISAN NATTHAWADEE
权利人:GE HEALTHCARE LTD
摘要:The present invention relates to a method for conditioning reversed phase SPE cartridges that provides certain advantages compared with known such methods. The method of the invention finds particular use in the automated synthesis of radiolabeled compounds where SPE is used for example in the purification steps.

专利号:WO-2011011384-A9
优先权日:2009-07-20
标 题 :Synthesis of dendrimer conjugates

专利号:DK-2336114-T3
优先权日:2007-12-07
标题:METHOD OF SYNTHESIS OF L-3,4 DIHYDROXY-6- [18F] FLUOR-PHENYLALANINE AND 2- [18F] FLUOR-L-TYROSIN AND THEIR ALFA METHYLERED DERIVATIVES STARTING FROM A PRECURSOR

专利号:US-8372380-B2
优先权日:2007-03-30
标 题:In vivo imaging of sulfotransferases
发明人：BARRIO JORGE R; KEPE VLADIMIR; SMALL GARY W; SATYAMURTHY NAGICHETTIAR
权利人:UNIV CALIFORNIA; BARRIO JORGE R; KEPE VLADIMIR; SMALL GARY W; SATYAMURTHY NAGICHETTIAR
摘要:Radiolabeled tracers for sulfotransferases (SULTs), their synthesis, and their use are provided. Included are substituted phenols, naphthols, coumarins, and flavones radiolabeled with 18 F, 123 I, 124 I, 125 I, or 11 C. Also provided are in vivo techniques for using these and other tracers as analytical and diagnostic tools to study sulfotransferase distribution and activity, in health and disease, and to evaluate therapeutic interventions.