合成目标产物 4-Tert-Butylbenzyl Alcohol 主要起始原料 Formaldehyde And 4-Tert-Butylphenylboronic Acid
26537-19-9 = 877-65-6 反应条件:1.1 Reagents: (Dimethyl Sulfide)Trihydroboron Solvents: 2-Methyltetrahydrofuran; 20 Min,90 °C 标题:Continuous-Flow Amide And Ester Reductions Using Neat Borane Dimethylsulfide Complex 作者:Oetvoes,Sandor B.; Et Al 参考文献:Chemsuschem 日期:2020 卷标:13(7) 页码:1800-1807]
98-73-7 = 877-65-6 反应条件:1.1 Reagents: Lithium Aluminum Hydride Solvents: Tetrahydrofuran; 0 °C; 6 H,0 °C; Overnight,25 °C; 25 °C -> 0 °C1.2 Reagents: Sodium Hydroxide Solvents: Water; 0 °C; 10 Min,0 °C 标题:Tertiary-Butylbenzene Functionalization As A Strategy For β-Sheet Polypeptides 作者:Nisal,Rahul; Et Al 参考文献:Biomacromolecules 日期:2022 卷标:23(6) 页码:2667-2684]
98-73-7 = 877-65-6 反应条件:1.1 Reagents: Phenylsilane Catalysts: 1816266-78-0 Solvents: Tetrahydrofuran; 20 H,30 °C; 30 °C -> Rt1.2 Reagents: Sodium Hydroxide Solvents: Water; 1 H,Rt 标题:Chelating Bis(1,2,3-Triazol-5-Ylidene) Rhodium Complexes: Versatile Catalysts For Hydrosilylation Reactions 作者:Nguyen,Thanh V. Q.; Et Al 参考文献:Advanced Synthesis & Catalysis 日期:2016 卷标:358(3) 页码:452-458]
624286-50-6 = 877-65-6 反应条件:1.1 Reagents: Silica,Water Catalysts: Nafion H Solvents: Hexane; 20 Min,Rt 标题:The Use Of Nafion-H As An Efficient Catalyst For The Deprotection Of Trimethylsilyl Ethers To Their Corresponding Alcohols Under Mild And Heterogeneous Conditions 作者:Zolfigol,Mohammad Ali; Et Al 参考文献:Phosphorus 日期:2004 卷标:179(11) 页码:2189-2193]
1058648-68-2 = 877-65-6 反应条件:1.1 Catalysts: 12-Tungstophosphoric Acid Solvents: Ethanol; 3.5 H,Reflux 标题:H3Pw12O40 - A Selective,Environmentally Benign,And Reusable Catalyst For The Preparation Of Methoxymethyl And Ethoxymethyl Ethers And Their Deprotection Under Mild Conditions 作者:Mohammadpoor-Baltork,Iraj; Et Al 参考文献:Canadian Journal Of Chemistry 日期:2008 卷标:86(8) 页码:831-840]
18880-00-7 = 877-65-6 反应条件:1.1 Reagents: Silica,Sodium Iodide Solvents: Acetone 标题:Oxidative Transformation Of Arylmethyl Bromides And Alcohols With A Combination Of Mesoporous Silica Fsm-16 And Alkali Iodides Under Photoirradiation 作者:Itoh,Akichika; Et Al 参考文献:Organic Letters 日期:2001 卷标:3(17) 页码:2653-2656]
18880-00-7 = 877-65-6 反应条件:1.1 Reagents: Oxygen Catalysts: Eosin Solvents: Dimethyl Sulfoxide; 12 H,25 °C 标题:Metal-Free,Visible-Light Photoredox Catalysis: Transformation Of Arylmethyl Bromides To Alcohols And Aldehydes 作者:Li,Jian; Et Al 参考文献:Rsc Advances 日期:2014 卷标:4(91) 页码:49974-49978]
= 877-65-6 反应条件:1.1 Reagents: Hantzsch Ester,Lithium Tetrafluoroborate Catalysts: Fac-Tris(2-(2-Pyridinyl)Phenyl)Iridium Solvents: Acetone; 2 H,22 - 27 °C 标题:Electrochemical Pinoylation Of Methylarenes: Improving The Scope And Utility Of Benzylic Oxidation Through Mediated Electrolysis 作者:Hoque,Asmaul Md; Et Al 参考文献:Journal Of The American Chemical Society 日期:2022 卷标:144(33) 页码:15295-15302]
39895-55-1 = 877-65-6 反应条件:1.1 Reagents: Methanol Catalysts: Sodium Hydroxide Solvents: Water; 2 H,7 Atm,240 °C1.2 Reagents: Hydrochloric Acid Solvents: Water; Neutralized 标题:Base-Catalyzed Direct Transformation Of Benzylamines Into Benzyl Alcohols 作者:Kanbara,Yutaka; Et Al 参考文献:Synlett 日期:2012 卷标:23(5) 页码:706-710]
1058648-72-8 = 877-65-6 反应条件:1.1 Catalysts: 1-Methylimidazolium Hydrogen Sulfate; 2 Min,120 °C 标题:Microwave-Assisted Rapid And Efficient Deprotection And Direct Esterification And Silylation Of Mom And Eom Ethers Catalyzed By [hmim][hso4] As A Bronsted Acidic Ionic Liquid 作者:Mohammadpoor-Baltork,Iraj; Et Al 参考文献:Monatshefte Fuer Chemie 日期:2010 卷标:141(10) 页码:1083-1088]
1058648-72-8 = 877-65-6 反应条件:1.1 Catalysts: 12-Tungstophosphoric Acid Solvents: Ethanol; 4 H,Reflux 标题:H3Pw12O40 - A Selective,Environmentally Benign,And Reusable Catalyst For The Preparation Of Methoxymethyl And Ethoxymethyl Ethers And Their Deprotection Under Mild Conditions 作者:Mohammadpoor-Baltork,Iraj; Et Al 参考文献:Canadian Journal Of Chemistry 日期:2008 卷标:86(8) 页码:831-840]
32857-63-9 = 877-65-6 反应条件:1.1 Reagents: Sodium Bicarbonate,Ceric Ammonium Nitrate Catalysts: Silver Carbonate,4,4′-Dimethyl [2,2′-Bipyridine]-4,4′-Dicarboxylate Solvents: Acetonitrile,Water; 12 H,55 °C1.2 Reagents: N-Methylformamide Solvents: Water; 12 H,100 °C 标题:Synthesis Of Benzylic Alcohols By Decarboxylative Hydroxylation 作者:Yu,Qian; Et Al 参考文献:Organic Letters 日期:2023 卷标:25(1) 页码:47-52]
26537-19-9 = 877-65-6 反应条件:1.1 Reagents: Diethylsilane Catalysts: Potassium Tert-Butoxide,(Sp-5-12)-[n2,N6-Bis(1,1-Dimethylethyl)-2,6-Pyridinedimethanamine-Kn1,Kn2,Kn6]Di... Solvents: Toluene; 20 Min,50 °C; 50 °C -> Rt1.2 Reagents: Hydrochloric Acid Solvents: Tetrahydrofuran; 2 H,Rt 标题:Cobalt-Catalysed Selective Synthesis Of Aldehydes And Alcohols From Esters 作者:Pattanaik,Sandip; Et Al 参考文献:Chemical Communications (Cambridge 日期:2020 卷标:56(53) 页码:7345-7348]
939-97-9 = 877-65-6 反应条件:1.1 Catalysts: Platinum,Copper Solvents: Isopropanol; 3 H,10 Bar,110 °C 标题:Ultrahigh Selective Hydrogenation Of Furfural Enabled By Modularizing Hydrogen Dissociation And Substrate Activation 作者:Wang,Shuai; Et Al 参考文献:Acs Catalysis 日期:2023 卷标:13(13) 页码:8720-8730]
939-97-9 = 877-65-6 反应条件:1.1 Reagents: Sodium Borohydride Solvents: Ethanol; 30 Min,Rt1.2 Reagents: Sodium Hydroxide Solvents: Water; Rt 标题:Direct Allylation Of Benzyl Alcohols,Diarylmethanols,And Triarylmethanols Mediated By Xtalfluor-E 作者:Lebleu,Thomas; Et Al 参考文献:Tetrahedron Letters 日期:2017 卷标:58(5) 页码:442-444]
939-97-9 = 877-65-6 反应条件:1.1 Reagents: Sodium Borohydride Solvents: Ethanol; 0 °C -> Rt; 2 - 3 H,Rt1.2 Reagents: Sodium Hydroxide Solvents: Water; 10 Min,Rt 标题:Snar Catalysis Enhanced By An Aromatic Donor-Acceptor Interaction; Facile Access To Chlorinated Polyfluoroarenes 作者:Senaweera,Sameera; Et Al 参考文献:Chemical Communications (Cambridge 日期:2017 卷标:53(54) 页码:7545-7548]
624286-50-6 = 877-65-6 反应条件:1.1 Reagents: Silica,Thionyl Chloride (Silica-Supported),Water Solvents: Hexane; 20 Min,Rt 标题:Deprotection Of Trimethylsilyl Ethers To Corresponding Alcohols Promoted By Silica Chloride: A Heterogeneous And Eco-Friendly Protocol 作者:Bamoniri,A.; Et Al 参考文献:Journal Of The Iranian Chemical Society 日期:2007 卷标:4(3) 页码:332-335]
624286-50-6 = 877-65-6 反应条件:1.1 Reagents: Silica Solvents: Hexane; 18 Min,Rt 标题:The Use Of Silica Sulfuric Acid As An Efficient Catalyst For Deprotection Of Trimethylsilyl Ethers To The Corresponding Alcohols Under Mild And Heterogeneous Conditions 作者:Bamoniri,A.; Et Al 参考文献:Journal Of The Iranian Chemical Society 日期:2006 卷标:3(1) 页码:85-88]
1058648-68-2 = 877-65-6 反应条件:1.1 Catalysts: 1-Methylimidazolium Hydrogen Sulfate; 2.5 Min,120 °C 标题:Microwave-Assisted Rapid And Efficient Deprotection And Direct Esterification And Silylation Of Mom And Eom Ethers Catalyzed By [hmim][hso4] As A Bronsted Acidic Ionic Liquid 作者:Mohammadpoor-Baltork,Iraj; Et Al 参考文献:Monatshefte Fuer Chemie 日期:2010 卷标:141(10) 页码:1083-1088]
18880-00-7 = 877-65-6 反应条件:1.1 Catalysts: Rhodamine B Solvents: Acetonitrile; 10 Min,Rt1.2 Reagents: Potassium Bicarbonate,Water; 34 H,Rt 标题:Visible-Light Driven Hydrolysis Of Benzyl Halides With Water For Preparation Of Benzyl Alcohols 作者:Xu,Jianbin; Et Al 参考文献:Asian Journal Of Organic Chemistry 日期:2019 卷标:8(2) 页码:261-264]
123324-71-0 = 877-65-6 反应条件:1.1 Reagents: Cesium Carbonate Catalysts: Di-μ-Chlorobis(η3-2-Propenyl)Dipalladium,1H-Imidazolium,1-[2,6-Bis(1-Methylethyl)Phenyl]-3-(2-Bromophenyl)-4,5-Dihydro-,... Solvents: Tetrahydrofuran,Water; 2 H,100 °C 标题:Palladium-Catalyzed Arylation Of Aldehydes With Bromo-Substituted 1,3-Diaryl-Imidazoline Carbene Ligand 作者:Yamamoto,Tetsuya; Et Al 参考文献:Tetrahedron 日期:2015 卷标:71(1) 页码:19-26]
3972-65-4 + 118496-00-7 = 877-65-6 反应条件:1.1 Reagents: Magnesium Solvents: Diethyl Ether,Dichloromethane 标题:Stabilization Of Reactive Aldehydes By Complexation With Methylaluminum Bis(2,6-Diphenylphenoxide) And Their Synthetic Application 作者:Maruoka,Keiji; Et Al 参考文献:Journal Of The American Chemical Society 日期:1993 卷标:115(10) 页码:3943-9]
118496-00-7 + 63488-10-8 = 877-65-6 [标题:Reaction Conditions 标题:Product Subclass 4: Aluminum Alkoxides And Phenoxides 作者:Ooi,T.; Et Al 参考文献:Science Of Synthesis 日期:2004 卷标:7 页码:131-195]
1710-98-1 = 877-65-6 [标题:Reaction Conditions 标题:The Synthesis Of Aldehydes By Means Of A Modified Rosenmund Reduction Of Acid Chlorides 作者:Peters,J. A.; Et Al 参考文献:Recueil Des Travaux Chimiques Des Pays-Bas 日期:1981 卷标:100(1) 页码:21-4]
600730-80-1 = 877-65-6 反应条件:1.1 Reagents: N-Methylformamide Solvents: Water; 12 H,100 °C 标题:Synthesis Of Benzylic Alcohols By Decarboxylative Hydroxylation 作者:Yu,Qian; Et Al 参考文献:Organic Letters 日期:2023 卷标:25(1) 页码:47-52]
98-73-7 + 25015-63-8 = 877-65-6 反应条件:1.1 12 H,Rt2.1 Reagents: Silica Solvents: Methanol; 6 H,50 °C 标题:Catalyst-Free Approach For Hydroboration Of Carboxylic Acids Under Mild Conditions 作者:Xu,Xiaojuan; Et Al 参考文献:Acs Omega 日期:2019 卷标:4(4) 页码:6775-6783]
524-38-9 = 877-65-6 反应条件:1.1 Reagents: Pyridine,Borate(1-),Tetrafluoro-,Hydrogen,Compd. With Pyridine (1:1:1),Oxygen Solvents: Acetonitrile,Dichloromethane; 40 - 60 Min,Rt2.1 Reagents: Hantzsch Ester,Lithium Tetrafluoroborate Catalysts: Fac-Tris(2-(2-Pyridinyl)Phenyl)Iridium Solvents: Acetone; 2 H,22 - 27 °C 标题:Electrochemical Pinoylation Of Methylarenes: Improving The Scope And Utility Of Benzylic Oxidation Through Mediated Electrolysis 作者:Hoque,Asmaul Md; Et Al 参考文献:Journal Of The American Chemical Society 日期:2022 卷标:144(33) 页码:15295-15302
对叔丁基氯苄置于sodium Hydroxide,水体系中,用 1,4-二氧六环 作为反应溶剂,化学反应生成 4-叔丁基苄醇 参考文献:Hojo,Masashi; Ueda,Tadaharu; Inoue,Sunao,Journal Of The Chemical Society. Perkin Transactions 2 (2001),2000,# 8,P. 1735-1740 标题:Hojo,Masashi; Ueda,Tadaharu; Inoue,Sunao,Journal Of The Chemical Society. Perkin Transactions 2 (2001),2000,# 8,P. 1735-1740
专利号:US-10308588-B2 优先权日:2014-12-15 标 题 :Synthesis of amides and amines from aldehydes or ketones by heterogeneous metal catalysis 发明人:CÓRDOVA ARMANDO; PALO-NIETO CARLOS; AFEWERKI SAMSON 权利人:ORGANOFUEL SWEDEN AB 摘要:A mild and efficient synthesis of primary amines and amides from aldehydes or ketones using a heterogeneous metal catalyst and amine donor is disclosed. The initial heterogeneous metal-catalyzed reaction between the carbonyl and the amine donor components is followed by the addition of a suitable acylating agent component in one-pot, thus providing a catalytic one-pot three-component synthesis of amides. Integration of enzyme catalysis allows for eco-friendly one-pot co-catalytic synthesis of amides from aldehyde and ketone substrates, respectively. The process can be applied to asymmetric synthesis or to the co-catalytic one-pot three-component synthesis of capsaicin and its analogues from vanillin or vanillyl alcohol. A co-catalytic reductive amination/dynamic kinetic resolution (dkr) relay sequence for the asymmetric synthesis of optically active amides from ketones is disclosed. Implementation of a catalytic reductive amination/kinetic resolution (kr) relay sequence produces the corresponding optically active amide product and optical active primary amine product with the opposite stereochemistry from the starting ketones.
专利号:US-6172226-B1 优先权日:1993-12-22 标 题:Synthons for the synthesis and deprotection of peptide nucleic acids under mild conditions 发明人:COULL JAMES M; EGHOLM MICHAEL; HODGE RICHARD P; ISMAIL MOHAMED; RAJUR S B 权利人:PERSEPTIVE BIOSYSTEMS INC 摘要:A method is disclosed for preparing novel PNA synthons having protecting groups capable of removal under mild conditions. The PNA synthons are prepared by coupling novel N-substituted nucleobase intermediates having carbamate protection of the exocyclic amino group of the heterocycle to an amino protected backbone or an amino protected backbone ester of the amino acid N-(2-aminoethyl)-glycine. By the method of this invention, the resultant PNA synthons can have orthogonal protection of the carbamate protected nucleobase and the amino protected backbone. The PNA synthons are useful in the synthesis of peptide nucleic acids (PNAs) and other oligomers such as PNA-DNA chimeras, and may be used in automated synthesizers. Novel compositions of matter are also disclosed. In addition, a guanine PNA synthon having selective carbamate protection of the exocyclic 2-amino group with the C6 carbonyl group unprotected is disclosed.
专利号:US-6469133-B2 优先权日:1999-12-13 标题 :Process for the preparation of polymers of dimeric cyclic esters 发明人:BAKER GREGORY L; SMITH III MILTON R 权利人:UNIV MICHIGAN STATE 摘要:The present invention provides a process for the direct synthesis of high melting polymers made from dimeric cyclic esters. In particular, the present invention provides a process for synthesis of polylactic acid (PLA) from racemic materials such as racemic lactide and polymandelide from mandelide. The process further provides racemic metal organic ligand catalysts such as racemic salbinap that catalyzes the polymerization of racemic dimeric cyclic ester monomers to a polylactide stereocomplex. Polymandelide and mixed dimeric cyclic esters are also prepared in the presence of low amounts of water.
专利号:US-6147217-A 优先权日:1997-02-04 标题:Synthesis of terfenadine and derivatives 发明人:SENANAYAKE CHRIS HUGH; FANG QUN KEVIN; WILKINSON SCOTT HAROLD 权利人:SEPRACOR INC 摘要:Processes for preparing compounds having the general formula: ##STR1## wherein R 1a is protected carboxy, carboxy, hydroxymethyl, protected hydroxymethyl, or methyl are disclosed. Processes of the invention begin with a starting material of the general formula IV ##STR2## wherein R 1 and R 2 are as defined in the specification.
专利号:US-2011183958-A1 优先权日:2008-10-17 标 题 :Azetidine derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase 发明人:POWELL DAVID; TRANMER GEOFFREY K 权利人:MERCK FROSST CANADA LTD 摘要:Azetidine derivatives of structural formula I are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD). The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; obesity; diabetes; neurological disease; Metabolic Syndrome; insulin resistance; cancer; liver steatosis; and non-alcoholic steatohepatitis.
专利号:US-9533957-B2 优先权日:2012-04-06 标题:Tetrazines and method of synthezising the same 发明人:DEVARAJ NEAL K; YANG JUN 权利人:UNIV CALIFORNIA 摘要:Provided herein, inter alia, are compositions and methods of synthesis and detection of tetrazines, e.g., a tetrazine of formula n nand diazonorcaradienes.
摘要:Kleoff, M.; Omoregbee, K.; Zimmer, R., Science of Synthesis Knowledge Updates, (2018) 4, 221. 摘要:Riva, R.; Banfi, L.; Basso, A., Science of Synthesis: Multicomponent Reactions, (2013) 1, 407. 摘要:Kaposi, M.; Witt, J.; Cokoja, M.; Kühn, F. E., Science of Synthesis: C-1 Building Blocks in Organic Synthesis, (2013) 2, 298. 摘要:Yi, C. S., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 1, 253. 摘要:Francke, R.; Prudlik, A.; Little, R. D., Science of Synthesis: Special Topics, (2021) 1, 305.