CAS: 87616-84-0; 6-Amino-2-(5,11-Bis((1H-Indol-3-yl)Methyl)-14-Amino-2-Benzyl-15-(1H-Imidazol-5-yl)-8-Methyl-4,7,10,13-Tetraoxo-3,6,9,12-Tetraazapentadecanamido)Hexanamide

该化合物是一种合成丙酸,其序列定义明确,包括L-和D-配置的氨基酸,以加强结构稳定性和生物活动,其独特的成分,以丁丁胺,试普潘,阿lanine,苯丙氨和赖氨残留物为特征,允许生物化学研究的潜在应用,包括受体结合研究和酶调节.乙酸盐形式确保水溶性得到改进和处理,其特征为高纯度和精确分子重量,适合需要严格质量控制的分析和实验应用.其定制序列还可能支持对pept-potein相互作用和治疗发展进行调查.

⚠️《2026年兴奋剂目录》
英文名称6-Amino-2-(5,11-Bis((1H-Indol-3-yl)Methyl)-14-Amino-2-Benzyl-15-(1H-Imidazol-5-yl)-8-Methyl-4,7,10,13-Tetraoxo-3,6,9,12-Tetraazapentadecanamido)Hexanamide
中文名称生长激素释放肽-6
IUPAC名称6-amino-2-(5,11-bis((1H-indol-3-yl)methyl)-14-amino-2-benzyl-15-(1H-imidazol-5-yl)-8-methyl-4,7,10,13-tetraoxo-3,6,9,12-tetraazapentadecanamido)hexanamide
其它别名D-Trp7,Ala8,D-Phe10]-A-Melanocytestimulatinghormoneamidefragment6-11; (2S)-6-Amino-2-[[2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-Amino-3-(3H-Imidazol-4-yl)Propanoyl]Amino]-3-(1H-Indol-3-yl)Propanoyl]Amino]Propanoyl]Amino]-3-(1H-Indol-3-yl)Propanoyl]Amino]-3-Phenyl-Propanoyl]Amino]Hexanamide; Growth Hormone Releasing Peptide; (D-Trp7,Ala8,D-Phe10)-A-Melanocyte*stimulating Ho; (D-Trp7,Ala8,D-Phe10)-A-Melanocyte*stimu Lating Horm; Growth; [d-Trp7, Ala8, D-Phe10]-α-Melanocyte Stimulating Hormone Amide Fragment 6-11
CAS编号87616-84-0
MFCD编号:MFCD00872694
FDA UNII编号:4H7N4I6X6A
分子式:C46H56N12O6
分子量:873.03
产品CID: 1884182
产品分类生物化工 → 多肽

相似结构搜索
InChIKey: WZHKXNSOCOQYQX-FUAFALNISA-N
WZHKXNS°COQYQX-FUAFALNISA-N…
计算化学: 氢键受体数18.0氢键供体数11.0可旋转键数28.0

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H319-H335
防范说明P261-P305+P351+P338
安全声明H303+H313+H333
WGK Germany3.0

合成工艺路线路线简述

105047-45-8 + 86123-10-6 + 116611-64-4 + 86123-11-7 + 35737-15-6 + 35661-39-3 = 87616-84-0
反应条件:1.1 Reagents: Diisopropylethylamine,1-[bis(Dimethylamino)Methylene]-1H-Benzotriazolium Hexafluorophosphate(1-) 3-Oxi... Solvents: Dimethylformamide; 45 Min,Rt1.2 Reagents: Piperidine Solvents: Dimethylformamide; 15 Min,Rt; 15 Min,Rt1.3 Reagents: Diisopropylethylamine,1-[bis(Dimethylamino)Methylene]-1H-Benzotriazolium Hexafluorophosphate(1-) 3-Oxi... Solvents: Dimethylformamide; 45 Min,Rt1.4 Reagents: Piperidine Solvents: Dimethylformamide; 15 Min,Rt; 15 Min,Rt1.5 Reagents: Diisopropylethylamine,1-[bis(Dimethylamino)Methylene]-1H-Benzotriazolium Hexafluorophosphate(1-) 3-Oxi... Solvents: Dimethylformamide; 45 Min,Rt1.6 Reagents: Piperidine Solvents: Dimethylformamide; 15 Min,Rt; 15 Min,Rt1.7 Reagents: Diisopropylethylamine,1-[bis(Dimethylamino)Methylene]-1H-Benzotriazolium Hexafluorophosphate(1-) 3-Oxi... Solvents: Dimethylformamide; 45 Min,Rt1.8 Reagents: Piperidine Solvents: Dimethylformamide; 15 Min,Rt; 15 Min,Rt1.9 Reagents: Diisopropylethylamine,1-[bis(Dimethylamino)Methylene]-1H-Benzotriazolium Hexafluorophosphate(1-) 3-Oxi... Solvents: Dimethylformamide; 45 Min,Rt1.10 Reagents: Piperidine Solvents: Dimethylformamide; 15 Min,Rt; 15 Min,Rt1.11 Reagents: Diisopropylethylamine,1-[bis(Dimethylamino)Methylene]-1H-Benzotriazolium Hexafluorophosphate(1-) 3-Oxi... Solvents: Dimethylformamide; 45 Min,Rt1.12 Reagents: Piperidine Solvents: Dimethylformamide; 15 Min,Rt; 15 Min,Rt1.13 Reagents: Trifluoroacetic Acid,Triethylsilyl Chloride Solvents: Water; 2 H,Rt
标题:Aza-Amino Acid Scanning Of Secondary Structure Suited For Solid-Phase Peptide Synthesis With Fmoc Chemistry And Aza-Amino Acids With Heteroatomic Side Chains
作者:Boeglin,Damien; Et Al
参考文献:Journal Of Combinatorial Chemistry 日期:2005 卷标:7(6) 页码:864-878]

105047-45-8 + 86123-10-6 + 116611-64-4 + 86123-11-7 + 35737-15-6 + 35661-39-3 = 87616-84-0
反应条件:1.1 -1.2 Reagents: Piperidine Solvents: Dimethylformamide; 17 Min,Rt1.3 Reagents: 1-[bis(Dimethylamino)Methylene]-5-Chloro-1H-Benzotriazolium 3-Oxide Hexafluoroph... Solvents: Dimethylformamide; 30 S,Rt1.4 Reagents: Diisopropylethylamine; 1 - 2 H,Rt1.5 Reagents: Piperidine Solvents: Dimethylformamide; 17 Min,Rt1.6 Reagents: 1-[bis(Dimethylamino)Methylene]-5-Chloro-1H-Benzotriazolium 3-Oxide Hexafluoroph... Solvents: Dimethylformamide; 30 S,Rt1.7 Reagents: Diisopropylethylamine; 1 - 2 H,Rt1.8 Reagents: Piperidine Solvents: Dimethylformamide; 17 Min,Rt1.9 Reagents: 1-[bis(Dimethylamino)Methylene]-5-Chloro-1H-Benzotriazolium 3-Oxide Hexafluoroph... Solvents: Dimethylformamide; 30 S,Rt1.10 Reagents: Diisopropylethylamine; 1 - 2 H,Rt1.11 Reagents: Piperidine Solvents: Dimethylformamide; 17 Min,Rt1.12 Reagents: 1-[bis(Dimethylamino)Methylene]-5-Chloro-1H-Benzotriazolium 3-Oxide Hexafluoroph... Solvents: Dimethylformamide; 30 S,Rt1.13 Reagents: Diisopropylethylamine; 1 - 2 H,Rt1.14 Reagents: Piperidine Solvents: Dimethylformamide; 17 Min,Rt1.15 Reagents: 1-[bis(Dimethylamino)Methylene]-5-Chloro-1H-Benzotriazolium 3-Oxide Hexafluoroph... Solvents: Dimethylformamide; 30 S,Rt1.16 Reagents: Diisopropylethylamine; 1 - 2 H,Rt1.17 Reagents: Piperidine Solvents: Dimethylformamide; 17 Min,Rt1.18 Reagents: Trifluoroacetic Acid,Triisopropylsilane Solvents: Water; 5 - 7 H,Rt
标题:Peptidomimetic Growth Hormone Secretagogue Derivatives For Positron Emission Tomography Imaging Of The Ghrelin Receptor
作者:Fowkes,Milan M.; Et Al
参考文献:European Journal Of Medicinal Chemistry 日期:2018 卷标:157 页码:1500-1511]

105047-45-8 + 116611-64-4 + 35737-15-6 + 35661-39-3 + 35661-40-6 = 87616-84-0
反应条件:1.1 Reagents: 4-Methylmorpholine,N-[1-(Cyano-2-Ethoxy-2-Oxoethylideneaminooxy)Dimethylamino(Morpholino)Uronium He... Solvents: Dimethylformamide; 1 Min,Rt1.2 Reagents: 4-Methylmorpholine,N-[1-(Cyano-2-Ethoxy-2-Oxoethylideneaminooxy)Dimethylamino(Morpholino)Uronium He... Solvents: Dimethylformamide; 1 Min,Rt1.3 Reagents: 4-Methylmorpholine,N-[1-(Cyano-2-Ethoxy-2-Oxoethylideneaminooxy)Dimethylamino(Morpholino)Uronium He... Solvents: Dimethylformamide; 1 Min,Rt1.4 Reagents: 4-Methylmorpholine,N-[1-(Cyano-2-Ethoxy-2-Oxoethylideneaminooxy)Dimethylamino(Morpholino)Uronium He... Solvents: Dimethylformamide; 1 Min,Rt1.5 Reagents: 4-Methylmorpholine,N-[1-(Cyano-2-Ethoxy-2-Oxoethylideneaminooxy)Dimethylamino(Morpholino)Uronium He... Solvents: Dimethylformamide; 1 Min,Rt1.6 Reagents: Trifluoroacetic Acid,Anisole,1,2-Ethanedithiol Solvents: Water; 2 H,Rt
标题:Fast Conventional Fmoc Solid-Phase Peptide Synthesis: A Comparative Study Of Different Activator
作者:Chantell,Christina Ann; Et Al
参考文献:Journal Of Peptide Science 日期:2012 卷标:18(2) 页码:88-91

海关参考信息

2902600000-乙苯
2912110000-甲醛
2912120000-乙醛
2921211000-乙二胺
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-2020354404-A1
优先权日:2019-05-09
标题 :Peptidomimetic agents, synthesis and uses thereof
发明人：AL-ABED YOUSEF
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Compounds for use in synthesis of peptidomimetic agents; synthesis of peptidomimetic agents; peptidomimetic diagnostic and therapeutic agents; and uses of the compounds and peptidomimetic agents in drug discovery, diagnosis, prevention and treatment of diseases are described.

专利号:US-2022401561-A1
优先权日:2019-09-30
标题 :Protein-macromolecule conjugates and methods of use thereof
发明人：SONG YUNTAO; LI HUI; ZHOU HAIPING; LIAO CHUAN
权利人:BEIJING XUANYI PHARMASCIENCES CO LTD
摘要:The present disclosure provides protein-macromolecule conjugates, releasable linkers, and macromolecules, as defined herein. The disclosed conjugates provide unique properties that ae based at least upon the properties of linker and number of linker-Macromolecule moieties. Also provided herein are a method of synthesis and use of conjugates in treating diseases and disorders.

专利号:US-11702652-B2
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries

专利号:US-10919882-B2
优先权日:2019-05-09
标题:Compounds for use in synthesis of peptidomimetics

专利号:US-7544351-B2
优先权日:2001-12-28
标题:Topical lightening compositions and methods of use
发明人：MAHALINGAM HARISH; JONES BRIAN; MENON GOPINATHAN K; KYROU CHRISTOS D; TRAUDT MICHAEL
权利人:AVON PROD INC
摘要:There is provided a topical lightening composition having a melanin synthesis-regulating agent and a vehicle. Also, there is provided a topical lightening composition having an extract of perilla leaf and a vehicle. In addition there is provided a topical lightening composition having a lightening agent selected from the group consisting of coconut water, palm water, palm nut milk, pecan nut milk, almond nut milk, cashew nut milk, walnut nut milk, concentrates of the foregoing, and any combinations thereof, along with a vehicle. The compositions and methods of the invention are effective to lighten skin, hair, lips, and/or nails.

专利号:US-11414405-B2
优先权日:2019-05-09
标题:Compounds for use in synthesis of peptidomimetics

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✅ COA系统入驻 | 共享模式

合成参考文献

参考文献:10.1159/000127112
摘要:Tena-Sempere M, Pinilla L, González D, Aguilar E. Involvement of endogneous nitric oxide in the control of pituitary responsiveness to different elicitors of growth hormone release in prepubertal rats. Neuroendocrinology. 1996 Aug;64(2):146–52. doi: 10.1159/000127112.
参考文献:10.1046/j.1365-2826.1996.04608.x
摘要:Bresson-Bepoldin L, Dufy-Barbe L. GHRP6-stimulated hormone secretion in somatotrophs: involvement of intracellular and extracellular calcium sources. J Neuroendocrinol. 1996 Apr;8(4):309–14. doi: 10.1046/j.1365-2826.1996.04608.x.
参考文献:10.1210/mend.15.9.0694
摘要:García A, Alvarez CV, Smith RG, Diéguez C. Regulation of Pit-1 expression by ghrelin and GHRP-6 through the GH secretagogue receptor. Mol Endocrinol. 2001 Sep;15(9):1484–95. doi: 10.1210/mend.15.9.0694.
摘要:Popovic V, Micic D, Damjanovic S, Djurovic M, Simic M, Gligorovic M, Dieguez C, Casanueva FF. Evaluation of pituitary GH reserve with GHRP-6. J Pediatr Endocrinol Metab. 1996 Jun;9 Suppl 3():289–98.
摘要:Pombo M, Leal-Cerro A, Barreiro J, Peñalva A, Peino R, Mallo F, Dieguez C, Casanueva FF. Growth hormone releasing hexapeptide-6 (GHRP-6) test in the diagnosis of GH-deficiency. J Pediatr Endocrinol Metab. 1996 Jun;9 Suppl 3():333–8.