CAS: 848133-35-7; (E)-4-(Dimethylamino)But-2-Enoic Acid Hydrochloride

相似化合物

149586-32-3 98548-82-4 98548-81-3

(2E)-4-(二甲基氨基)-2-丁烯酸甲酯置于sodium Hydroxide,水,盐酸体系中,用 甲醇,水 作为反应溶剂,化学反应 1.0H,以51%的收率获得产物反式-4-二甲基胺基巴豆酸盐酸盐
参考文献: Substituted Tricyclic Compounds And Methods Of Use Thereof[fr] Composés Tricycliques Substitués Et Leurs Procédés D'Utilisation
标题: Substituted Tricyclic Compounds And Methods Of Use Thereof[fr] Composés Tricycliques Substitués Et Leurs Procédés D'Utilisation
摘要:这项发明涉及新颖化合物及其制备方法,治疗疾病的方法,特别是癌症,包括给予这些化合物,以及制备用于治疗或预防疾病,特别是癌症的药物组合物的方法.

专利信息

专利号:US-9242965-B2
优先权日:2013-12-31
标题:Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors
发明人：ZHENG JUNCHENG; DENG DA; LV GUANGHUA; YAN JUN; BRANDENBURG JOERG; KROEBER JUTTA; SCHOLZ ULRICH
权利人:BOEHRINGER INGELHEIM INT
摘要:The present invention is directed to an efficient process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form of formula I n nwherein R 1 and R 2 independently denote C 1-3 -alkyl groups and X − denotes an acid anion, such as the chloride, bromide, tosylate, mesylate or trifluoroacetate anion, with high quality, and a process for synthesis of EGFR tyrosine kinase inhibitors with heterocyclic quinazoline, quinoline or pyrimidopyrimidine core structure, using the acid addition salt I and activated derivatives thereof as intermediates.

专利号:US-7126025-B2
优先权日:2003-01-21
标 题 :Synthesis of 4-(amino)-2-butenoyl chlorides and their use in the preparation of 3-cyano quinolines
发明人：CONSIDINE JOHN LEO; DAIGNEAULT SYLVAIN; CHEW WARREN; IERA SILVIO; DUNCAN SCOTT MASON; REN JIANXIN
权利人:WYETH CORP
摘要:This invention provides a compound of Formula (I): n nwhereinn S 1 and S 2 are each independently, hydrogen, alkyl, alkenyl, alkynyl, aralkyl, substituted or unsubstituted aryl, and S 1 and S 2 together with the nitrogen to which they are attached form a nitrogen containing heteroaryl and a pharmaceutically acceptable salt thereof; a method of preparing the compound of Formula (I), and use of the compound of Formula (I) in the preparation of 3-cyano quinolines.

专利号:US-2004162442-A1
优先权日:2003-01-21
标 题 :Synthesis of 4-(amino)-2-butenoyl chlorides and their use in the preparation of 3-cyano quinolines

专利号:EP-3089961-B1
优先权日:2013-12-31
标 题:Process for the manufacture of (e)-4-n,n-dialkylamino crotonic acid in hx salt form and use thereof for synthesis of egfr tyrosine kinase inhibitors

专利号:EP-3089961-A1
优先权日:2013-12-31
标题 :Process for the manufacture of (e)-4-n,n-dialkylamino crotonic acid in hx salt form and use thereof for synthesis of egfr tyrosine kinase inhibitors

专利号:CA-2514550-A1
优先权日:2003-01-21
标题:Synthesis of 4amino-2-butenoyl chlorides and their use in the preparation of 3-cyano quinolines