CAS: 760-84-9; L-Leucine (Hydrochloride)

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61-90-5 114360-54-2 13139-15-6

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CAS号4530-20-5 B°C-甘氨酸 | CAS号110449-50-8 [(1S,2R)-10-(N,... | CAS号61-90-5 L-亮氨酸 | CAS号2743-60-4 L-亮氨酸乙酯 | CAS号13139-15-6 B°C-L-亮氨酸 | CAS号1480-30-4 L-Leucine,N-(2,... | CAS号35661-60-0 Fm°C-L-亮氨酸 | CAS号13139-15-6 B°C-L-亮氨酸 | CAS号26117-20-4 氨基甲酰-L-亮氨酸

📜Boc-L-亮氨酸置于硫酸,Sodium Chloride体系中,用 Neat (No Solvent) 作为反应溶剂,化学反应 3.0H,以99%的收率获得产物l-亮氨酸盐酸盐
参考文献:通过异位反应生成氯化氢气体进行无溶剂 N-Boc 脱保护
标题:通过异位反应生成氯化氢气体进行无溶剂 N-Boc 脱保护
摘要:描述了一种有效,可扩展且可持续的方法,用于在无溶剂条件下使用低至接近化学计量的氯化氢气体对氨基甲酸叔丁酯 (N-Boc) 保护基团进行定量脱保护.我们展示了在两室反应器中从氯化钠和硫酸异位反应生成氯化氢气体,介绍了一种用于控制和化学计量释放 Hcl 气体的简单方法.无溶剂条件允许对多种n进行脱保护-Boc衍生物以定量产率获得盐酸盐.该程序消除了对任何后处理或纯化步骤的需要,为标准方法提供了一种简单的绿色替代方案.由于无溶剂,无水条件,该方法对酸敏感官能团具有高耐受性,并提供扩展的官能团正交性.
DOI:10.1039/d1Ob00728A

专利信息

专利号:US-2012088848-A1
优先权日:1998-03-19
标 题 :Methods and compositions for controlled polypeptide synthesis
发明人：DEMING TIMOTHY J; YU MIAOER; CURTIN SCOTT A; HWANG JUNGYEON; WYRSTA MICHAEL D; NOWAK ANDREW; SEIDEL SCOTT W
权利人:DEMING TIMOTHY J; YU MIAOER; CURTIN SCOTT A; HWANG JUNGYEON; WYRSTA MICHAEL D; NOWAK ANDREW; SEIDEL SCOTT W
摘要:Methods and compositions for the generation of polypeptides having varied material properties are disclosed herein. Methods include means for initiating the polymerization of aminoacid-N-carboxyanhydride (NCA) monomer by combining the monomer with an amido-containing metallacycle, for making self assembling amphiphilic block copolypeptides and related protocols for adding oligo(ethyleneglycol) functionalized aminoacid-N-carboxyanhydrides (NCAs) to polyaminoacid chains. Additional methods include means of adding an end group to the carboxy terminus of a polyaminoacid chain by reacting an alloc-protected amino acid amide with a transition metal-donor ligand complex to forming an amido-amidate metallacycle for use in further polymerization reactions. Novel compositions for use in peptide synthesis and design including five and six membered amido-containing metallacycles and block copolypeptides are also disclosed.

专利号:US-7968519-B2
优先权日:1998-03-19
标 题 :Methods and compositions for controlled polypeptide synthesis
发明人：DEMING TIMOTHY J; YU MIAOER; CURTIN SCOTT A; HWANG JUNGYEON; WYRSTA MICHAEL D; NOWAK ANDREW; SEIDEL SCOTT W
权利人:UNIV CALIFORNIA
摘要:Methods and compositions for the generation of polypeptides having varied material properties are disclosed herein. Methods include means for initiating the polymerization of aminoacid-N-carboxyanhydride (NCA) monomer by combining the monomer with an amido-containing metallacycle, for making self assembling amphiphilic block copolypeptides and related protocols for adding oligo(ethyleneglycol) functionalized aminoacid-N-carboxyanhydrides (NCAs) to polyaminoacid chains. Additional methods include means of adding an end group to the carboxy terminus of a polyaminoacid chain by reacting an alloc-protected amino acid amide with a transition metal-donor ligand complex to forming an amido-amidate metallacycle for use in further polymerization reactions. Novel compositions for use in peptide synthesis and design including five and six membered amido-containing metallacycles and block copolypeptides are also disclosed.

专利号:US-6632922-B1
优先权日:1998-03-19
标题 :Methods and compositions for controlled polypeptide synthesis
发明人：DEMING TIMOTHY J; CURTIN SCOTT A
权利人:UNIV CALIFORNIA
摘要:Methods and compositions for the generation of polypeptides having varied material properties are disclosed herein. Methods include means for making self assembling amphiphilic block copolypeptides and related protocols adding oligo(ethyleneglycol) functionalized aninoacid-N-carboxyanhydrides (NCAs) to polyaminoacid chains. Additional methods include means of adding an end group to the carboxy terminus of a polyaminoacid chain by reacting an alloc-protected amino acid amide with a transition metal-donor ligand complex, thereby forming an amido-amidate metallacycle for use in further polymerization reactions. Novel compositions for use in peptide synthesis and design including five and six membered amido-containing metallacycles and block copolypeptides are also disclosed.

专利号:CN-104788330-B
优先权日:2015-03-25
标题:A kind of preparation and synthesis method of chiral double L-leucine hydrochloride

专利号:CN-104788330-A
优先权日:2015-03-25
标 题 :A kind of preparation and synthesis method of chiral double L-leucine hydrochloride