CAS: 759-36-4; Diethyl Isopropylmalonate

相似化合物

601-79-6 2612-27-3 15112-52-4

上下游产品

n-butyl magnesium bromide diethyl isopropylidenemalonate diethyl ether cycl-isopropylidene malonate5-isopropyl-1-phenylbarbituric acid ethyl 3-methylhexanoate diethyl (1-methylbutyl)malonate Ethyl isovalerate

亚异丙基丙二酸二乙酯置于ru[o-(Sime2)2(C6H4)]2(H)2[cn-2,4,6-Me3(C6H2)]2,氢气体系中,用 甲苯 作为反应溶剂,25.0 °C,1.01 Mpa 条件下,反应 9.0H,以92%的收率获得产物异丙基丙二酸二乙酯
参考文献:含异氰化物配体的二硅油环和铁环配合物作为未官能化空间位阻烯烃加氢的有效催化剂
标题:含异氰化物配体的二硅油环和铁环配合物作为未官能化空间位阻烯烃加氢的有效催化剂
摘要:合成了含有异氰基异氰化物作为配体 3' 和 4' 的二硅铁和二硅油环配合物,并通过光谱学和晶体学表征.3' 和 4' 对烯烃的加氢均表现出优异的催化活性.与铁和钌的羰基类似物 1' 和 2' 相比,异氰化物配合物 3' 和 4' 在氢化条件下更加坚固,并且即使在较高的温度(~80 oc)和高氢气压力(~ 20 个大气压).在目前报道的铁催化剂中,铁配合物 3' 对单,二,三和四取代烯烃的氢化表现出最高的催化活性.钌配合物 4' 在非常温和的条件下催化氢化,例如室温和 1 个大气压的 H2.4' 对未官能化的四取代烯烃的加氢具有非常高的催化活性,这一点尤其值得注意,因为它与 Crabtree 和 Pfaltz 报道的铱配合物的活性相当,后者是文献中活性最高的催化剂.dft 计算表明有两个可能的催化循环,这两个循环都涉及通过晚期过渡金属的 σ 键复分解(氧化氢迁移)由金属-硅键辅助的 H2 活
DOI:10.1021/jacs.8B00812

专利信息

专利号:US-6051704-A
优先权日:1996-07-22
标题:Synthesis of macrocyclic tetraamido-N ligands
发明人：GORDON-WYLIE SCOTT W; COLLINS TERRENCE J
权利人:UNIV CARNEGIE MELLON
摘要:New synthetic methods for the preparation of macrocyclic amido-N donor ligands are provided. The primary method of the present invention involves in general only two synthetic steps. In the first step, an α or β amino carboxylic acid is allowed to react with an optimal (approximately stoichiometric) amount of an activated malonate or oxalate derivative with mild heating. Upon completion of the double coupling reaction, hydrolysis of the reaction mixture yields a diamide containing intermediate (a macro linker). In the second step, stoichiometric amounts of a diamine, preferably an orthophenylene diamine, are added to the macro linker intermediate in the presence of a coupling agent and heat. This second double coupling reaction, is allowed to proceed for a period of time sufficient to produce a macrocyclic tetraamido compound. The substituent groups on the α or β amino carboxylic acid, the malonate, and the aryl diamine may all be selectively varied so that the resulting tetraamido macrocycle can be tailored to specific desired end uses. The macrocyclic tetraamide ligand may then be complexed with a metal, such as a transition metal, and preferably the middle and later transition metals, to form a robust chelate complex suitable for catalyzing oxidation reactions.

专利号:WO-2012078147-A1
优先权日:2010-12-08
标 题:A process for the preparation of intermediates useful in the production of aliskiren
发明人：BHANU MANJUNATH NARAYAN; NAIK SAMIR; THOMAS REJOY
权利人:WATSON LAB INC; BHANU MANJUNATH NARAYAN; NAIK SAMIR; THOMAS REJOY
摘要:A process for preparing 4-[(2R)-2-X-methyl)-3-methylbutyl]-1 -methoxy-2-3(3- methoxypropoxy)-benzene wherein X is a leaving group and use of this compound in the synthesis of aliskiren.

专利号:US-7060818-B2
优先权日:2003-02-21
标题:Synthesis of macrocyclic tetraamido compounds and new metal insertion process
发明人：HORWITZ COLIN P; GHOSH ANINDYA
权利人:UNIV CARNEGIE MELLON
摘要:An improved method of synthesizing a macrocyclic tetraamido compound includes protecting the amino portion of an amino carboxylic acid to form a protected amino carboxylic acid; exposing the protected amino carboxylic acid to a first solvent, preferably a hydrocarbon solvent, such as toluene or 1,2-dichloroethane, dichloromethane, dibromomethane and 1,2-dibromoethane. The carboxylic acid portion of the protected amino carboxylic acid is then converted to an activated carboxylic acid by one of esterification or acid halide formation, to form a protected amino activated carboxylic acid derivative. The protected amino activated carboxylic acid derivative is reacted with a diamine in the presence of a second solvent, such as THF or ,2-dichloroethane, dichloromethane, dibromomethane and 1,2-dibromoethane, to form a protected diamide diamine intermediate. Following deprotection, the diamide diamine intermediate is reacted with an activated diacid, such as an activated malonate, oxalate or succinate derivative to form the macrocyclic tetraamido compound. The macrocyclic tetraamido compound may further be complexed with a transition metal.

专利号:US-9896523-B2
优先权日:2015-06-26
标题 :Ziegler-Natta catalyst synthesis and process thereof
发明人：SINGH GURMEET; KUMAR NARESH; KAUR SUKHDEEP; BANTU BHASKER; KAPUR GURPREET SINGH; SHASHIKANT
权利人:INDIAN OIL CORP LTD
摘要:The present invention describes a process of preparing a catalyst for olefin polymerization comprising: (i) treating a magnesium metal with an organohalide along with an internal donor to obtain a reaction mixture having solid component (A); (ii) treating the reaction mixture having solid component (A) with an acyl halide to obtain a reaction mixture having solid component (B); and (iii) treating the reaction mixture having solid component (B) of step (ii) with a transition metal compound to obtain the catalyst. The present invention also relates to a process for preparation of a catalyst system from said catalyst and preparation of a polyolefins from the catalyst system.

专利号:US-6011152-A
优先权日:1996-07-22
标 题 :Synthesis of macrocyclic tetraamido-N ligands

专利号:US-3928347-A
优先权日:1968-11-08
标 题:Pyrazinylmalonic acid esters and salts and pyrazinylacetic acids, esters and salts
发明人：SCHWARTZ NORMAN; MOHRBACHER RICHARD J
权利人:MCNEILAB INC
摘要:The compound, 2,3-diphenyl-5-ethylpyrazine, useful as a precursor in the synthesis of those compounds of the class of pyrazine, arylpyrazine, diphenylpyrazine, and cycloalkylpyrazine malonates, acetates, acetamides, and acetic acids, useful for their ultraviolet light absorption properties.