专利号:US-6399787-B1 优先权日:1997-06-13 标 题:Catalytic asymmetric hydrogenation, hydroformylation, and hydrovinylation via transition metal catalysts with phosphines and phosphites 发明人:ZHANG XUMU 权利人:PENN STATE RES FOUND 摘要:Novel transition metal catalysts with conformationally rigid chiral phosphines and phosphites are developed for asymmetric carbon-hydrogen and carbon-carbon bond formation. The invention emphasizes synthesis of chiral amines, beta-amino acids and related compounds via catalytic asymmetric hydrogenation based on chiral monodentate and bidentate phosphines with cyclic ring structures. The ligands contain rigid ring structures.
专利号:US-7893296-B2 优先权日:2002-07-30 标题:Method for producing an optically active β-amino acid 发明人:MATSUMURA KAZUHIKO; ZHANG XIAOYONG; SAITO TAKAO 权利人:TAKASAGO PERFUMERY CO LTD 摘要:Disclosed is a producing method of an optically active β-amino acid useful as intermediate for the production of medicines, agricultural. chemicals and physiologically active substances, by means of a catalytic and asymmetric synthesis method of high performance and a high enantiomeric excess, without requiring additional procedures such as introduction and removal of protecting group and so on. The method includes subjecting an enamine to an asymmetric hydrogenation.
参考标题:Nickel-Catalyzed Enantioselective Hydrogenation Of β-(Acylamino)Acrylates: Synthesis Of Chiral β-Amino Acid Derivatives 作者:Xiuxiu Li,Cai You,Shuailong Li,Hui Lv,Xumu Zhang |发布日期:2017.10.6 摘要:β-(Acylamino)Acrylates Has Been Developed, Affording Chiral β-Amino Acid Derivatives With Excellent Yields (95-99% Yield) And Enantioselectivities (97-99% Ee). With The Ni-Binapine System, High Enantioselectivities (98-99% Ee) Have Also Been Obtained In The Hydrogenation Of Z/e Isomeric Mixtures Of β-Alkyl And β-Aryl β-(Acylamino)Acrylates. The Synthesis Of Chiral β-Amino Acid Derivatives On A Gram Scale Has Also