CAS: 67654-58-4; Methyl (S)-3-Acetamido-3-Phenylpropanoate

该化合物是一种有机化合物,其特性为酯功能组,该化合物来自酒精和碳酸酯的反应,其特性为酒精和碳酸;该化合物的特性为与丙酸结构相连的甲基酯,以及乙基氨基丙酸组,表明有矿衍生物;立体化学的具体规定为(S),其中建议对原子作出特定空间安排,从而影响其生物活动和再活动;通常,这种性质的化合物在有机溶剂中可能表现出中等溶性,在水中溶性有限.由于存在极性功能组,甲基(S)-(乙基氨基)苯丙酸丙酸酯可能因其潜在的生物活动而对药物的应用,特别是药物设计和合成具有兴趣.与许多有机化合物一样,应参考安全数据,以了解其处理,储存和潜在危害.

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上下游产品

(E)-methyl 3-acetamido-3-phenyl-2-propenoate N-((S)-1-phenylbut-3-enyl)acetamide diazomethyl-trimethyl-silane methyl (Z)-3-acetylamino-3-phenylacrylate

合成工艺路线路线简述

    📜Methyl 3-((4-Methoxyphenyl)Amino)-3-Phenylpropanoate置于ammonium Cerium (Iv) Nitrate,水,三乙胺体系中,用 氯仿,乙腈 作为反应溶剂,化学反应生成 (S)-N-乙酰基-Beta-苯丙氨酸甲酯
    参考文献:刘易斯碱催化的β-烯氨基酯的氢化硅烷化反应高度对映选择性地合成了β-氨基酸衍生物.
    标题:刘易斯碱催化的β-烯氨基酯的氢化硅烷化反应高度对映选择性地合成了β-氨基酸衍生物.
    摘要:
    DOI:10.1002/chem.200801582

    海关参考信息

    专利信息


    专利号:US-6399787-B1
    优先权日:1997-06-13
    标 题:Catalytic asymmetric hydrogenation, hydroformylation, and hydrovinylation via transition metal catalysts with phosphines and phosphites
    发明人:ZHANG XUMU
    权利人:PENN STATE RES FOUND
    摘要:Novel transition metal catalysts with conformationally rigid chiral phosphines and phosphites are developed for asymmetric carbon-hydrogen and carbon-carbon bond formation. The invention emphasizes synthesis of chiral amines, beta-amino acids and related compounds via catalytic asymmetric hydrogenation based on chiral monodentate and bidentate phosphines with cyclic ring structures. The ligands contain rigid ring structures.

    专利号:US-7893296-B2
    优先权日:2002-07-30
    标题:Method for producing an optically active β-amino acid
    发明人:MATSUMURA KAZUHIKO; ZHANG XIAOYONG; SAITO TAKAO
    权利人:TAKASAGO PERFUMERY CO LTD
    摘要:Disclosed is a producing method of an optically active β-amino acid useful as intermediate for the production of medicines, agricultural. chemicals and physiologically active substances, by means of a catalytic and asymmetric synthesis method of high performance and a high enantiomeric excess, without requiring additional procedures such as introduction and removal of protecting group and so on. The method includes subjecting an enamine to an asymmetric hydrogenation.

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    主要参考文献

    参考标题:Nickel-Catalyzed Enantioselective Hydrogenation Of β-(Acylamino)Acrylates: Synthesis Of Chiral β-Amino Acid Derivatives
    作者:Xiuxiu Li,Cai You,Shuailong Li,Hui Lv,Xumu Zhang |发布日期:2017.10.6
    摘要:β-(Acylamino)Acrylates Has Been Developed, Affording Chiral β-Amino Acid Derivatives With Excellent Yields (95-99% Yield) And Enantioselectivities (97-99% Ee). With The Ni-Binapine System, High Enantioselectivities (98-99% Ee) Have Also Been Obtained In The Hydrogenation Of Z/e Isomeric Mixtures Of β-Alkyl And β-Aryl β-(Acylamino)Acrylates. The Synthesis Of Chiral β-Amino Acid Derivatives On A Gram Scale Has Also
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