2,4-二羟基苯甲酸置于水,溶剂黄146体系中,化学反应生成 4-溴间苯二酚 参考文献:Rice,Journal Of The American Chemical Society,1926,Vol. 48,P. 3127 标题:Rice,Journal Of The American Chemical Society,1926,Vol. 48,P. 3127
专利号:US-9745281-B2 优先权日:2013-02-14 标 题 :Method for the synthesis of 4-(heterocycloalkyl)-benzene-1,3,-diol compounds 发明人:BOITEAU JEAN-GUY 权利人:GALDERMA RES & DEV 摘要:A method is described for the synthesis of 4-(heterocycloalkyl)-benzene-1,3-diol compounds of general formulae (I) and (II): n nwherein X can be an oxygen atom or a sulphur atom. Also described, is a method for the synthesis of the reactive intermediates of general formula (7a) or (7b)n n nNovel compounds as synthesis intermediates are also described.
专利号:US-9981887-B1 优先权日:2017-01-10 标题 :Synthesis of phenylethynylbenzenes 发明人:LASKOSKI MATTHEW; KELLER TEDDY M 权利人:US NAVY 摘要:A method of: reacting a dihydroxybenzene with bromine to form a bromodihydroxybenzene; reacting the bromodihydroxybenzene with trifluoromethanesulfonyl chloride or trifluoromethanesulfonic anhydride to form a bromotrifluoromethanesulfonatobenzene; and reacting the bromotrifluoromethanesulfonatobenzene with phenylacetylene to form a phenylethynylbenzene.
专利号:US-9650337-B2 优先权日:2013-02-14 标 题 :Method of synthesising 4-piperidin-4-yl-benzene-1,3-diol and the salts of same and novel compound tert-butyl 4-(2,4-dihydroxy-phenyl)-4-hydroxy-piperidine-1-carboxylate 发明人:BOITEAU JEAN-GUY; MUSICKI BRANISLAV 权利人:GALDERMA RES & DEV 摘要:A method is described for the synthesis of 4-piperidin-4-yl-benzene-1,3-diol of the following formula (I): n nand the pharmaceutically acceptable salts thereof. Also described, is tert-butyl 4-(2,4-dihydroxy-phenyl)-4-hydroxy-piperidine-1-carboxylate as a novel intermediate compound
专利号:US-2024335442-A1 优先权日:2021-08-02 标 题:N-acylhydrazone compounds capable of inhibiting nav1.7 and/or nav1.8, processes for the preparation thereof, compositions, uses, methods for treatment using same, and kits 发明人:BARREIRO GABRIELA; SANT'ANA DANILO PEREIRA DE; GAMBA LUIS EDUARDO REINA; FRAGA CARLOS ALBERTO MANSSOUR; BARREIRO ELIEZER JESUS DE LACERDA; LIMA LÃ?DIA MOREIRA 权利人:EUROFARMA LABORATORIOS S A; UNIV FEDERAL DO RIO DE JANEIRO UFRJ 摘要:N-acylhydrazone compounds that are Nav 1.7 and/or Nav 1.8 inhibitors, including N-acylhydrazone compounds of Formula (I), wherein the substituents R1 to R6 are independently selected from the groups defined in the specification, as well as to the processes for the preparation thereof, compositions comprising at least one of said compounds, uses, treatment methods for treating or preventing pain-related pathologies, and kits, and which are applicable in the fields of medicinal chemistry and organic synthesis, as well as in the treatment of pain-related disorders.
专利号:US-2016185749-A1 优先权日:2013-02-14 标题:Method for the synthesis of 4-(heterocycloalkyl)-benzene-1,3,-diol compounds
专利号:EP-1000918-B1 优先权日:1998-10-26 标 题 :Process for checking the synthesis of organic molecules in combinatorial chemistry 发明人:SCHROEDER HARALD; NEIDIG KLAUS-PETER 权利人:BRUKER BIOSPIN GMBH
摘要:Kwiecień, H., Science of Synthesis Knowledge Updates, (2014) 4, 68. 参考文献:10.1080/10934520600620188 摘要:LAPERTOT M, PICHAT P, PARRA S, GUILLARD C, PULGARIN C. Photocatalytic Degradation ofp-Halophenols in TiO2Aqueous Suspensions: Halogen Effect on Removal Rate, Aromatic Intermediates and Toxicity Variations. Journal of Environmental Science and Health, Part A. 2006 Jul;41(6):1009–25. doi: 10.1080/10934520600620188.