专利号:US-12441721-B2 优先权日:2020-07-21 标 题 :Synthesis of heterocyclic compounds from carboxamide and carboxamide derivatives with haloalkanols 发明人:KARPOORMATH RAJSHEKHAR; SAYYAD NISAR 权利人:UNIV OF KWAZULU NATAL 摘要:The invention provides for methods for the synthesis of various compounds through reaction of carboxamide, or carboxamide derivatives, with various substituted or unsubstituted haloalkanols in a one-step, single vessel, reaction mechanism. Preferably, but not exclusively, the reaction proceeds in the absence of any solvents, catalyst, base, or any further reagents.
专利号:US-4219489-A 优先权日:1978-09-05 标题:Synthesis of steroids 发明人:BUNES LEONARD A; JOHNSON WILLIAM S 权利人:STANFORD LELAND JUNIOR UNIV TR 摘要:Method and compounds are provided for use in the synthesis of steroids wherein a polyolefin is provided having an initiating group having a chalcogen atom in juxtaposition to a double bond, so as to be capable of bond formation to close to form a ring and having a terminating group involving pi unsaturation (a double or triple bond) conjugated to an aromatic ring. Upon acid catalysis, sigma bonds are formed through the interaction of a carbocation formed at the carbon atom bonded to the chalcogen atom and the double bond intermediate the initiating group and the terminating group, which close to form rings of a steroid nucleus, the carbocation interacting with the pi unsaturation conjugated with the aromatic group and being captured by a nucleophile present in the acidic reaction medium. The resulting steroid product may then be modified in known ways to produce known steroids.
专利号:US-8835627-B2 优先权日:2012-03-27 标 题 :Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid 发明人:LE FLOHIC ALEXANDRE; GRANDJEAN MATHIEU 权利人:SERVIER LAB 摘要:Process for the synthesis of ivabradine of formula (I): n nand addition salts thereof with a pharmaceutically acceptable acid.
专利号:US-3954818-A 优先权日:1974-11-25 标 题:Synthesis of non-4-en-6-ynoic acid ester 发明人:LABOVITZ JEFFERY N; HENRICK CLIVE A 权利人:ZOECON CORP 摘要:Steroselective synthesis of the sex pheromone (7E, 9Z)-7,9-dodecadien-1-yl acetate of the grape vine moth Lobesia botrana and intermediates therefor.
专利号:US-4014946-A 优先权日:1974-11-25 标 题:Synthesis of 1-bromonon-4-en-6-yne 发明人:LABOVITZ JEFFERY N; HENRICK CLIVE A 权利人:ZOECON CORP 摘要:Steroselective synthesis of the sex pheromone (7E, 9Z)-7,9-dodecadien-1-yl acetate of the grape vine moth Lobesia botrana and intermediates therefor.
专利号:US-3987073-A 优先权日:1974-04-25 标 题:Synthesis of tridecadienoic esters 发明人:ANDERSON RICHARD J; HENRICK CLIVE A 权利人:ZOECON CORP 摘要:Synthesis of the sex pheromone, (7Z,11Z/E)-7,11-hexadecadienyl acetate, of the pink bollworm moth, Pectinophora gossypiella, and intermediates therefor.
[参考文献]: Alfonso Pérez-Garrido, Et Al. Halogenated Derivatives Qsar Model Using Spectral Moments To Predict Haloacetic Acids (Haa) Mutagenicity. Bioorg Med Chem. 2008 May 15;16(10):5720-32. [参考文献]: C D Geddes, Et Al. Chloride-Sensitive Fluorescent Indicators. Anal Biochem. 2001 Jun 1;293(1):60-6. [参考文献]: Takeo Kawabata, Et Al. Stereochemical Diversity In Asymmetric Cyclization Via Memory Of Chirality. J Am Chem Soc. 2006 Dec 6;128(48):15394-5.
合成参考文献
摘要:Stanforth, S. P., Science of Synthesis Knowledge Updates, (2014) 3, 130. 摘要:Ulfkjær, A.; Pittelkow, M., Science of Synthesis Knowledge Updates, (2018) 1, 138. 摘要:Kelly, C. B.; Matsui, J. K.; Phelan, J. P.; Gutiérrez Bonet, Á.; Lang, S. B.; Molander, G. A., Science of Synthesis: Photocatalysis in Organic Synthesis, (2018) 1, 355. 摘要:Primer, D. N.; Molander, G. A., Science of Synthesis, (2019) , 302. 摘要:Lee, B. C.; Lin, L.; Ko, C.; Koh, M. J., Science of Synthesis: Special Topics, (2022) 1, 493.