CAS: 604-99-9; ((6S,10S,11As)-9-Ethylidene-5,6,8,9,10,11,11A,12-Octahydro-6,10-Methanoindolo[3,2-B]Quinolizin-11-yl)Methanol
化学文摘社编号为604-99-9,作为该物质在化学数据库中的独特识别器,便利其在各个科学领域的研究和应用;与许多藻类一样,诺马库辛B在医药用途方面的安全和功效需要彻底调查,包括毒性评估和临床试验,以充分了解其潜在惠益和风险.
- 英文名称((6S,10S,11As)-9-Ethylidene-5,6,8,9,10,11,11A,12-Octahydro-6,10-Methanoindolo[3,2-B]Quinolizin-11-yl)Methanol
- 中文名称妥包嗪
- IUPAC名称((6S,10S,11aS)-9-ethylidene-5,6,8,9,10,11,11a,12-octahydro-6,10-methanoindolo[3,2-b]quinolizin-11-yl)methanol
- 其它别名(+)-Normacusine B; Normacusine B; Sarpagan-17-Ol; Tombozine; Vellosiminol; Vellosimol; (+)-Normacusine B
- CAS编号604-99-9
- MFCD编号:MFCD20260686
- FDA UNII编号:8RD788YSD2
- 分子式:C19H22N2O分子量:294.4
- 产品CID: 2512062
- 产品分类天然产物 → 生物碱
物理性质
- 熔点270-2°C (245°C)
- 沸点472.7±45.0 °C(预测)
- 闪点239.7 °C
- 密度1.30±0.1 g/cm3(预测)
- pKa:14.79±0.10(预测)
- PSA:39.26
- LogP:2.9619
- 折射率1.705
- 蒸汽压9.65E-10 mmHg at 25 °C
- 溶解性Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- 外观形态粉末
- 储存条件Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
- 产品应用该化合物是第三级碱性碱性醇,与STRYCHNOS ATLANTICA KRUKOFF和BARNEBY的根皮完全隔绝.
MSDS等安全信息
上下游产品
(Z)-(+)-(16S)-12-benzyl-10-desoxy-18-hydroxysarpagine indole(6R,10R)-(+)-5-benzyl-9-oxo-12-(prop-2-ynyl)-6,7,8,9,10,11-hexahydro-6,10-imino-5H-cyclo°Ctindole (S)-3-(1-Benzyl-1H-indol-3-yl)-2-{[1-phenyl-meth-(E)-ylidene]-amino}-propionic acid methyl ester Sarpagine (+)-taberpsychine sarpagine (19Z)-taberpsychine 5-Bromo-2-fluoro-benzonitrile 2-amino-5-bromobenzonitrile 5-bromo-3-(N,N-dimethylamino)-1H-indazole 5-bromo-N-methyl-1H-indazol-3-amine 5-bromo-1H-indazole tert-butyl 3-[bis(tert-butoxycarbonyl)amino]-5-(5-chloro-2-hydroxyphenyl)-1H-indazole-1-carboxylate合成工艺路线路线简述
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2902200000-苯
2905121000-正丙醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Kitajima M, Watanabe K, Maeda H, Kogure N, Takayama H. Asymmetric Total Synthesis of Sarpagine-Related Indole Alkaloids Hydroxygardnerine, Hydroxygardnutine, Gardnerine, (E)-16-epi-Normacusine B, and Koumine. Org Lett. 2016 Apr 15;18(8):1912-5. doi: 10.1021/acs.orglett.6b00661. Epub 2016 Apr 1. doi: 10.1016/S0944-7113(96)80009-2. doi: 10.1055/s-0030-1250569. Epub 2010 Nov 23.
合成参考文献
参考文献:10.5281/zenodo.5794106
摘要:The LOTUS Initiative for Open Natural Products Research: frozen dataset union wikidata (with metadata) | DOI:10.5281/zenodo.5794106
📝 需求与反馈
尽可能描述清楚需求与问题信息
