CAS: 55589-47-4; 3-Methylpicolinaldehyde

相似化合物

20970-75-6 4021-07-2 59718-84-2

上下游产品

CAS号63071-09-0 (3-甲基吡啶-2-基)甲醇 | CAS号583-61-9 2,3-二甲吡啶 | CAS号52814-41-2 2-乙酰氧基甲基-3-甲基吡啶... | CAS号22710-07-2 2,3-二甲基吡啶氮氧化物 | CAS号3430-17-9 2-溴-3-甲基吡啶 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号67-56-1 甲醇 | CAS号22382-94-1 3-甲基-2-烯基吡啶 | CAS号4021-07-2 3-甲基-2-吡啶甲酸 | CAS号20970-75-6 2-氰基-3-甲基吡啶

2,3-二甲基吡啶置于manganese(Iv) Oxide,2,2,2-三氟苯乙酮,双氧水,Potassium Carbonate,乙腈,三氟乙酸酐体系中,用 二氯甲烷,水,1,2-二氯乙烷,叔丁醇 作为反应溶剂,化学反应 73.0H,反应生成 3-甲基-2-吡啶醛
参考文献:Methyl Scanning And Revised Binding Mode Of 2-Pralidoxime,An Antidote For Nerve Agent Poisoning
标题:Methyl Scanning And Revised Binding Mode Of 2-Pralidoxime,An Antidote For Nerve Agent Poisoning
摘要:Organophosphorus Nerve Agents (Opnas) Inhibit Acetylcholinesterase (Ache) And,Despite The Chemical Weapons Convention Arms Control Treaty,Continue To Represent A Threat To Both Military Personnel And Civilians. 2-Pralidoxime (2-Pam) Is Currently The Only Therapeutic Countermeasure Approved By The United States Food And Drug Administration For Treating Opna Poisoning. However,2-Pam Is Not Centrally Active Due To Its Hydrophilicity And Resulting Poor Blood-Brain Barrier Permeability; Hence,These Deficiencies Warrant The Development Of More Hydrophobic Analogs. Specifically,Gaps Exist In Previously Published Structure Activity Relationship (Sar) Studies For 2-Pam,Thereby Making It Difficult To Rationally Design Novel Analogs That Are Concomitantly More Permeable And More Efficacious. In This Study,We Methodically Performed A Methyl Scan On The Core Pyridinium Of 2-Pam To Identify Ring Positions That Could Tolerate Both Additional Steric Bulk And Hydrophobicity. Subsequently,Sar-Guided Molecular Docking Was Used To Rationalize Hydropathically Feasible Binding Modes For 2-Pam And The Reported Derivatives. Overall,The Data Presented Herein Provide New Insights That May Facilitate The Rational Design Of More Efficacious 2-Pam Analogs.
DOI:10.1021/acsmedchemlett.9B00586

专利信息

专利号:US-8962839-B2
优先权日:2010-11-19
标题:Chiral spiro-pyridylamidophosphine ligand compound, synthesis method therefor and application thereof
发明人：ZHOU QILIN; XIE JIANHUA; LIU XIAOYAN; XIE JIANBO; WANG LIXIN
权利人:ZHOU QILIN; XIE JIANHUA; LIU XIAOYAN; XIE JIANBO; WANG LIXIN; ZHEJIANG JIUZHOU PHARMA SCIENCE & TECHNOLOGY CO LTD
摘要:The present invention relates to a chiral spiro-pyridylamidophosphine ligand compound, synthesis method therefor and application thereof. The chiral spiro-pyridylamidophosphine compound is a compound having a structure of Formula (I), a racemate or optical isomer thereof, or a catalytically acceptable salt thereof, and is mainly characterized by having a chiral spiro-dihydro-indene skeleton in its structure. The chiral spiro-pyridylamidophosphine compound may be synthesized with optical active 7-diaryl/alkylphosphino-7′-amino-1,1′-spiro-dihydro-indene or substituted 7-diaryl/alkylphosphino-7′-amino-1,1′-spiro-dihydro-indene having a spiro-skeleton as chiral starting material. The chiral spiro-pyridylamidophosphine compound may be used as a chiral ligand in asymmetric hydrogenation of a carbonyl compound catalyzed by iridium, in which the reaction activity is very high, the amount of the catalyst may be 0.0001 mol %, and the enantioselectivity of the reaction is up to 99.9% ee.

专利号:CN-110128472-B
优先权日:2018-02-08
标 题 :Synthesis and application of an oxaspirocyclic PNN-type ligand