📜4-Methyl-4-Nitrovaleronitrile置于苯硅烷,三正丁基氢锡体系中,用 甲苯 作为反应溶剂,化学反应 8.0H,以70%的收率获得产物4-甲基戊腈 参考文献:Bu3Snh-Catalyzed Reduction Of Nitroalkanes To Alkanes 标题:Bu3Snh-Catalyzed Reduction Of Nitroalkanes To Alkanes 摘要: DOI:10.1021/jo980789K
专利号:US-9879043-B1 优先权日:2013-06-06 标 题:Synthesis of non-natural cofactor analogs of S-adenosyl-L-methionine using methionine adenosyltransferase 发明人:THORSON JON; HUBER TYLER; ZHANG JIANJUN; Singh Shanteri 权利人:UNIV KENTUCKY RES FOUND 摘要:The present disclosure relates to the synthesis of non-natural analogs of S-adenosyl-L-methionine (SAM) and/or of Se-adenosyl-L-methionine (SeAM) by reacting a methionine analog and adenosine triphosphate (ATP) in the presence of at least one methionine adenosyltransferase (MAT), and to use thereof with downstream SAM and/or SeAM utilizing enzymes. The non-natural analogs of SAM and/or SeAM have the general formula: n nwhere X is S or Se, and R 1 is an alkyl group.
专利号:EP-0468457-B1 优先权日:1990-07-24 标题 :Novel substituted piperidines and their use as inhibitors of cholesterol synthesis 发明人:MCCARTHY JAMES R; BARNEY CHARLOTTE L; WANNAMAKER MARION W 权利人:MERRELL DOW PHARMA 摘要:The present invention relates to a group of compounds which are novel substituted piperidines and which act to inhibit the synthesis of cholesterol in mammals and in fungi.
专利号:EP-0420116-B1 优先权日:1989-09-22 标 题 :Novel substituted alkyl piperidines and their use as inhibitors of cholesterol synthesis 发明人:MCCARTHY JAMES RAY; WANNAMAKER MARION WOODS; BARNEY CHARLOTTE LOUISE 权利人:MERRELL PHARMA INC 摘要:The present invention relates to a group of compounds which are novel substituted alkyl piperidines and which are useful in the treatment of fungal infections through the inhibition of cholesterol synthesis in mammals.
专利号:US-6355490-B1 优先权日:1996-09-13 标题:Attached tags for use in combinatorial chemistry synthesis 发明人:HOCHLOWSKI JILL EDIE; SOWIN THOMAS J; NORBECK DANIEL W; GRILLOT ANNE-LAURE MARIE; SWENSON ROLF E 摘要:The present invention relates to a process of coding and identifying individual members of a chemical combinatorial library synthesized on a plurality of solid supports which undergo mix and split synthesis. The process provides for tagging the solid supports with a coding identifier that is attached to the solid support and which can be decoded by infrared or raman spectroscopy when directly attached to the support.
专利号:US-11912734-B2 优先权日:2020-01-28 标题:Solid-phase synthesis of oligonucleotides containing N6-(2-deoxy-alpha,beta-derythropentofuranosyl)-2,6-diamino-4-hydroxy-5-formamidopyrimidine (Fapyâ‹…dG) 发明人:GREENBERG MARC M; YANG HAOZHE 权利人:UNIV JOHNS HOPKINS 摘要:A strategy using reverse phosphoramidites for synthesizing oligonucleotides containing Fapy·dG is disclosed.
专利号:US-5217979-A 优先权日:1989-09-22 标题:Substituted alkyl piperidines 发明人:MCCARTHY JAMES R; BARNEY CHARLOTTE L; WANNAMAKER MARION W 权利人:MERRELL DOW PHARMA 摘要:The present invention relates to a group of compounds which are novel substituted alkyl piperidines and which act to inhibit the synthesis of cholesterol in mammals and in fungi.
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