CAS: 526-07-8; 5-(((1R,3Ar,4S,6Ar)-4-(Benzo[d][1,3]Dioxol-5-yl)Hexahydrofuro[3,4-C]Furan-1-yl)Oxy)Benzo[d][1,3]Dioxole

该化合物是一种天然化合物,被归类为离子体,主要见于芝麻种子和油,以其抗氧化性特性和潜在健康惠益闻名,包括抗炎和胆固醇低效效应;Sesamolin具有复杂的化学结构,有助于其生物活动;该物质经常因其在促进心血管健康方面的作用及其在预防癌症方面的潜力而接受研究;除其健康惠益外,在食品工业中,Sesamolin还被用作天然防腐剂,因为它能够抑制脂氧化;其溶解性特征表明它比水中有机溶剂更容易溶解,影响其在不同配方中的应用;此外,Sesamolin因其在热量下的稳定而得到承认,因此适合烹饪和食品加工;

结构式图片

欧盟法规

C&L通报

合成工艺路线路线简述

    📜1-(3,4-Methylendioxyphenyl)-2,3-Bis-Hydroxymethylpent-4-En-1-Ol置于4-二甲氨基吡啶,Potassium Permanganate,D(+)-10-樟脑磺酸,氧气,Copper Diacetate体系中,用 二氯甲烷,水,异丙醇 作为反应溶剂,化学反应 4.0H,反应生成 芝麻林素
    参考文献:用于植物保护的呋喃呋喃木脂素:作为新型抗烟草花叶病毒和抗菌剂的芝麻素及其衍生物的发现
    标题:用于植物保护的呋喃呋喃木脂素:作为新型抗烟草花叶病毒和抗菌剂的芝麻素及其衍生物的发现
    摘要:天然产物一直是高效,低风险农药的宝贵来源.本工作通过呋喃呋喃木脂素富马林ii的结构简化,设计合成了一系列新型芝麻林衍生物a0-A31和b0-B4,并系统评价了它们的抗病毒和抗菌活性.生物测定结果表明,化合物a24对烟草花叶病毒(tmv)具有显着的灭活活性,Ec 50值为130.4 μg/ml,优于市售宁南霉素(ec 50 = 202.0 μg/ml).抗病毒作用模式测定表明,化合物a24可能通过与 Tmv 外壳蛋白 (Cp) 结合来阻碍自组装,从而抵抗 Tmv 感染.此外,化合物a25具有显着的抗菌活性,特别是对青枯菌,Ec 50值为43.8 μg/ml,优于市售的双噻唑和噻二唑铜.该研究为呋喃喃木脂素在作物保护中的应用奠定了坚实的基础.
    DOI:10.1021/acs.Jafc.3C03257

    海关参考信息

    专利信息


    专利号:US-10799441-B2
    优先权日:2011-06-06
    标题:Skin treatments containing pyrroloquinoline quinone (PQQ) esters and methods of preparation and use thereof
    发明人:LEWIS II JOSEPH ABERNATHY; DINARDO JOSEPH C
    权利人:LEWIS II JOSEPH ABERNATHY; DINARDO JOSEPH C; PCR TECH HOLDINGS LC
    摘要:The present invention relates to cosmetic or dermatological compositions containing PQQ or its esters, methods of treating or promoting skin changes by topical application of these compositions, and methods of synthesis of PQQ esters. The PQQ ester-containing compositions of the present invention are unexpectedly effective in treating skin, particularly with respect to skin tolerance. When included in a topical composition, the PQQ esters of the present invention have an antioxidant effect that is useful in treating a skin change.

    专利号:US-2018333433-A1
    优先权日:2017-05-18
    标题 :Synthesis of silver nanoparticles using sesame oil cake
    发明人:ALSALHI MOHAMAD SALEH; DEVANESAN SANDHANASAMY; ALFURAYDI AKRAM AHMED; AL-ANSARI MYSOON M F
    权利人:UNIV KING SAUD
    摘要:A method of synthesizing silver nanoparticles includes using sesame ( Sesamum indicum ) oil cake extract as a reducing agent. The silver nanoparticles can range in size from about 6 nm to about 15 nm. The silver nanoparticles can have an average particle size of about 10 nm.

    专利号:WO-2025056767-A1
    优先权日:2023-09-15
    标题 :Process for the preparation of enantiomerically enriched aliphatic amines
    发明人:BOU HAMDAN FARHAN; GODINEAU EDOUARD; SMEJKAL TOMAS; DUMEUNIER RAPHAEL; BOUSSEMGHOUNE MOHAMED ABDELOUAHAB; BLUM MATHIAS
    权利人:SYNGENTA CROP PROTECTION AG
    摘要:The present invention relates to a process for the preparation of enantiomerically enriched cyclobutylamines of formula (I) from α-tertiary cyclobutanones and reacting said enantiomerically enriched cyclobutylamines to enantiomerically enriched cyclobutylamides. Such compounds are useful intermediates in the synthesis of microbiocidal thiazole compounds.

    专利号:US-2025164360-A1
    优先权日:2022-06-09
    标 题:On-slide synthesis of a schiff reagent
    发明人:BIRD JEAN MARIE; CANTORIA MARY JO CASTRO; DURRANT EDWARD E; HANNON ANDREW
    权利人:VENTANA MED SYST INC
    摘要:The present disclosure is directed to compositions, kits, and methods for synthesizing a Schiff's reagent in situ, i.e., directly on a substrate, such as within a puddle disposed on the surface of a substrate. In some embodiments, the kits comprise at least a dye composition and a sulfite composition. In some embodiments, the dye composition comprises a compound having a 4-Benzhydrylidene-2,5-cyclohexadien-1-imine core functionalized to include at least two substituted or unsubstituted amine groups, wherein the compound has a molecular weight ranging from between about 300 g/mol to about 600 g/mol. In some embodiments, the dye composition optionally includes an acid. In some embodiments, the sulfite composition comprises a sulfite or SO2 source.

    专利号:US-9987208-B2
    优先权日:2013-04-04
    标题 :Elastin synthesis/regeneration promoting agent
    发明人:NISHIZAKI TOMOYUKI; TANAKA AKITO
    权利人:NISHIZAKI BIOINFORMATION RES INSTITUTE
    摘要:8-[2-(2-Pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid (DCP-LA) has an action to promote synthesis and regeneration of elastin, and is useful as an agent for the prophylaxis or improvement of wrinkles, and an anti-aging drug.

    专利号:WO-0007607-A1
    优先权日:1998-08-04
    标 题:Nutrient and therapeutic compositions for the treatment of cancer
    权利人:KOSBAB JOHN V
    摘要:This invention relates to nutrient and therapeutic compositions for the treatment of cancer symptoms and conditions. Compositions of this invention contain a mixture of antioxidants, components that promote collagen maintenance and synthesis, components that regulate blood lipids, glucose and/or insulin, and lower homocysteine levels. Compositions also provide supplementation for nutrient (vitamin, mineral and cofactor) deficiencies to restore and maintain normal biochemical function. Cancer formulations, particularly those adapted for treatment of female cancers, can be combined with components that provide benefit in osteoporosis.

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Kim DY, Oh S, Ko HS, Park S, Jeon YJ, Kim J, Yang DK, Park KW. Sesamolin suppresses adipocyte differentiation through Keap1-dependent Nrf2 activation in adipocytes. Nutr Res. 2024 Aug;128:14-23. doi: 10.1016/j.nutres.2024.05.005. Epub 2024 May 29.
    457:140079. doi: 10.1016/j.foodchem.2024.140079. Epub 2024 Jun 11.
    452:139555. doi: 10.1016/j.foodchem.2024.139555. Epub 2024 May 6. 29(1):63. doi: 10.1186/s11658-024-00583-9.

    合成参考文献


    摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
    参考文献:10.1007/bf02256096|10.1159/000077897
    摘要:Shen CC, Huang HM, Ou HC, Chen HL, Chen WC, Jeng KC. Protective effect of nicotinamide on neuronal cells under oxygen and glucose deprivation and hypoxia/reoxygenation. J Biomed Sci. 2004 Jul;11(4):472–81. doi: 10.1007/bf02256096.
    参考文献:10.1186/1742-2094-8-57
    摘要:Hsieh PF, Hou CW, Yao PW, Wu SP, Peng YF, Shen ML, Lin CH, Chao YY, Chang MH, Jeng KC. Sesamin ameliorates oxidative stress and mortality in kainic acid-induced status epilepticus by inhibition of MAPK and COX-2 activation. J Neuroinflammation. 2011 May 24;8():57.
    参考文献:10.1186/s12870-021-03132-0
    摘要:Dossou SSK, Xu F, Cui X, Sheng C, Zhou R, You J, Tozo K, Wang L. Comparative metabolomics analysis of different sesame (Sesamum indicum L.) tissues reveals a tissue-specific accumulation of metabolites. BMC Plant Biology. 2021 Jul 24;21(1):352. doi: 10.1186/s12870-021-03132-0.
    参考文献:10.1016/j.neulet.2004.05.073
    摘要:Hou RC, Wu CC, Yang CH, Jeng KC. Protective effects of sesamin and sesamolin on murine BV-2 microglia cell line under hypoxia. Neurosci Lett. 2004 Aug 26;367(1):10–3. doi: 10.1016/j.neulet.2004.05.073.
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