CAS: 4023-34-1; Cyclopropanecarboxylic Acid Chloride

相似化合物

16480-05-0 54322-65-5 1489-69-6

上下游产品

CAS号1759-53-1 环丙甲酸 | CAS号155-22-6 cyclopropanecar... | CAS号79-37-8 草酰氯 | CAS号4747-72-2 异氰酰基环丙烷 | CAS号50664-71-6 环丙基4-乙基苯基酮 | CAS号14385-15-0 N-(4-chlorophen... | CAS号1453-50-5 Cyclopropanecar... | CAS号14372-07-7 N-(3-bromopheny... | CAS号31594-49-7 1-cyclopropylpe... | CAS号14113-96-3 1,2-二环丙基乙酮 | CAS号1489-91-4 Phosphonic acid... | CAS号150322-73-9 1-环丙基-2-(2-氟苯基)乙酮 | CAS号95-52-3 邻氟甲苯

环丙甲酸置于氯化亚砜体系中,化学反应 2.0H,反应生成 环丙基甲酰氯
参考文献:有力和亚型选择性cck-B /胃泌素受体拮抗剂:具有对称平面的2,4-二氧-1,5-苯并二氮杂pine.
标题:有力和亚型选择性cck-B /胃泌素受体拮抗剂:具有对称平面的2,4-二氧-1,5-苯并二氮杂pine.
摘要:设计,合成了一系列具有对称平面的cck-B /胃泌素受体拮抗剂,2,4-二氧代-1,5-苯并二氮杂卓衍生物,并评估了其拮抗活性.构效关系研究表明,在n-1和n-5位置上的羰基甲基和亲水基团(例如在c-3位置与脲基相连的苯环上的羧基)带来了强大的亲和力和亚型对cck-B /胃泌素受体的选择性.在麻醉的大鼠中,几种化合物对五肽胃泌素诱导的胃酸分泌具有出色的体内抑制作用.
DOI:10.1016/s0968-0896(97)00083-7

专利信息

专利号:US-5861532-A
优先权日:1997-03-04
标 题:Solid-phase synthesis of N-alkyl amides
发明人：BROWN EDWARD G; NUSS JOHN M
权利人:CHIRON CORP
摘要:Methods for solid phase synthesis of N-alkyl amides comprise reductive amination of carbonyl compounds using a reducing agent and an amine-containing linker bound to a solid support. The methods afford high yields of linker-bound, monoalkylated amines, and subsequent coupling with acid derivatives provide derivatized N-substituted amides in excellent yields after cleavage from the solid-phase. Compositions useful in solid phase synthesis are also described.

专利号:US-9085538-B2
优先权日:2010-07-26
标题:Process for the preparation of key intermediates for the synthesis of statins or pharmaceutically acceptable salts thereof
发明人：CASAR ZDENKO; STERK DAMJAN; JUKIC MARKO
权利人:CASAR ZDENKO; STERK DAMJAN; JUKIC MARKO; LEK PHARMACEUTICALS
摘要:The invention relates to commercially viable process for the synthesis of key intermediates for the preparation of statins, in particular Rosuvastatin and Pitavastatin or respective pharmaceutically acceptable salts thereof. A new simple and short synthetic route for key intermediates is presented which benefits from the use of cheap and readily available starting materials, by which the conventionally most frequently used DIBAL-H as reducing agent can be avoided.

专利号:EP-1735276-B1
优先权日:2004-04-02
标题:Novel method for the preparation of intermediates useful for the synthesis of vitamin d analogues
发明人：HANSEN ERIK TORNGAARD; SABROE THOMAS PETER; CALVERLEY MARTIN JOHN; PEDERSEN HENRIK; DEUSSEN HEINZ-JOSEF WILHELM
权利人:LEO PHARMA AS
摘要:The present invention relates to novel methods for the preparation of intermediates which are useful in the synthesis of cacipotriol. The present invention relates further to the use of intermediates produced with said methods for making calcipotriol or calcipotriol monohydrate.

专利号:EP-3617181-A1
优先权日:2018-08-30
标题:Synthesis of trans-2-phenylcyclopropylamine or a salt or solvate thereof
发明人：BREUNING ALEXANDER; LIMMERT MICHAEL; DELLING AXEL; HOFMEIER HARALD; HULTSCH JANA; MICKSCH MAIK; SOMMER CHRISTIAN
权利人:AREVIPHARMA GMBH
摘要:The present invention relates to the field of manufacturing trans-2-phenylcyclopropylamine or a salt or solvate thereof, in particular in the form of the sulphate salt. The obtained product, particularly when in the form of the synthesis of trans-2-phenylcyclopropylamine sulphate, is exceptionally pure, substantially free from reactants and reagents that are mutagenic, hazardous or of great concern to the health of humans or the environment.

专利号:US-6608196-B2
优先权日:2001-05-03
标题 :Process for solid supported synthesis of pyruvate-derived compounds
发明人：WANG BING; JANAGANI SATYANARAYANA; CALLAWAY WYETH B; SESSLER JONATHAN L
权利人:GALILEO PHARMACEUTICALS INC
摘要:Provided are processes for synthesizing structurally diverse pyruvate-derived compounds using a parallel approach on a solid phase support. Examples of such a solid phase support include resins which have also been used in solid phase peptide synthesis.

专利号:US-2024309003-A1
优先权日:2021-05-04
标题 :Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
发明人：HOUZE JONATHAN B; BOS MAXENCE; MANCUSO JOHN; FRANZONI IVAN; PANDYA BHAUMIK; KAPLAN ALAN
权利人:VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2â€?). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.