CAS: 3877-86-9; (2S,8S,9R,10R,13R,14S,16R,17R)-17-((R,E)-2,6-Dihydroxy-6-Methyl-3-Oxohept-4-En-2-yl)-2,16-Dihydroxy-4,4,9,13,14-Pentamethyl-1,4,7,8,9,10,12,13,14,15,16,17-Dodecahydro-3H-Cyclopenta[a]Phenanthrene-3,11(2H)-Dione

上下游产品

cucurbitacin B23,24-dihydr°Cucurbitacin D is°Cucurbitacin D cucurbitacin I

📜葫芦素 B置于lithium Hydroxide体系中,用 甲醇,水 作为反应溶剂,化学反应 2.0H,以97.2%的收率获得产物葫芦素 D
参考文献:葫芦素衍生物及其制备方法
标题:葫芦素衍生物及其制备方法
摘要:本发明公开了葫芦素b和葫芦素e的多种新衍生物,以及它们的盐,还公开了这些新衍生物的制备方法,这些新衍生物以及它们的盐,由于分别与葫芦素b,葫芦素e具有共同的基本结构,所以性质也基本与葫芦素b,葫芦素e一样,具有较好的抗癌,抗病毒,抗炎症和保肝脏作用,而且毒副作用较低.

专利信息

专利号:US-2008248097-A1
优先权日:2007-02-26
标题 :Polymeric micelles for combination drug delivery
发明人：KWON GLEN S; BAE YOUNSOO; ALANI ADAM WG
权利人:KWON GLEN S; BAE YOUNSOO; ALANI ADAM WG
摘要:The invention provides block polymers, micelles, and micelle formulations for combination drug therapy. Polyamide block polymers, such as those of formulas I and II are useful, for example, for preparation of mixed drug micelles, including simply mixed micelles, physically mixed micelles, and chemically mixed micelles. The invention further provides methods of treating cancer, and inhibiting and killing cancer cells. Also provided are methods for the preparation of polymer drug conjugates and intermediates for their synthesis.