CAS: 3084-40-0; Diethyl (Hydroxymethyl)Phosphonate

相似化合物

31618-90-3 1474-78-8 32806-04-5

上下游产品

CAS号762-04-9 亚磷酸二乙酯 | CAS号50-00-0 甲醛 | CAS号94-09-7 对氨基苯甲酸乙酯 | CAS号122-52-1 亚磷酸三乙酯 | CAS号75-11-6 二碘甲烷 | CAS号64-17-5 乙醇 | CAS号3167-63-3 氯甲基膦酸二乙酯 | CAS号33512-26-4 邻苯二亚胺甲基磷酸二乙酯 | CAS号38066-16-9 二乙基(苯基硫代甲基)磷酸酯 | CAS号180587-75-1 (R)-9-[2-(二乙基膦酰... | CAS号683-08-9 甲基膦酸二乙酯 | CAS号24600-04-2 1-[chloromethox... | CAS号89268-01-9 diethoxyphospho... | CAS号31618-90-3 对甲苯磺酰氧甲基膦酸二乙酯 | CAS号71885-51-3 [(四氢吡喃-2-基氧代)甲基... | CAS号54553-21-8 2-苯基乙基磷酸二乙酯

二乙基亚磷酸氢酯置于三乙胺,Paraformaldehyde体系中,用57.5 G (68%)的收率获得产物羟甲基膦酸二乙酯
参考文献:Phosphonic Acid-Substituted Benzazepinone-N-Acetic Acid Derivatives
标题:Phosphonic Acid-Substituted Benzazepinone-N-Acetic Acid Derivatives
摘要:具有nep抑制活性的化合物,对应于公式i,其中r.Sup.1是氢或形成生物可陌生磷酸酯的基团,R.Sup.2是氢或形成生物可陌生磷酸酯的基团,R.Sup.3是氢或形成生物可陌生羧酸酯的基团,以及公式i的酸的生理上可接受的盐,以及含有这些化合物的药物组合物.

专利信息

专利号:US-8304409-B2
优先权日:2002-07-03
标 题:Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
发明人：EARL RICHARD A; EZAWA MAIKO; FANG XINQIN; GARVEY DAVID S; GASTON RICKY D; KHANAPURE SUBHASH P; LETTS L GORDON; LIN CHIA-EN; RANATUNGE RAMANI R; RICHARDSON STEWART K; SCHROEDER JOSEPH D; STEVENSON CHERI A; WEY SHIOW-JYI
权利人:EARL RICHARD A; EZAWA MAIKO; FANG XINQIN; GARVEY DAVID S; GASTON RICKY D; KHANAPURE SUBHASH P; LETTS L GORDON; LIN CHIA-EN; RANATUNGE RAMANI R; RICHARDSON STEWART K; SCHROEDER JOSEPH D; STEVENSON CHERI A; WEY SHIOW-JYI; NICOX SA
摘要:The invention describes novel nitrosated nonsteroidal antiinflammatory drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated NSAID, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one nitrosated NSAID, and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one nitrosated NSAID, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating inflammation, pain and fever; for treating gastrointestinal disorders; for facilitating wound healing; for treating and/or preventing gastrointestinal, renal and/or respiratory toxicities resulting from the use of nonsteroidal antiinflammatory compounds; for treating inflammatory disease states and/or disorders; and for treating and/or preventing ophthalmic diseases and/or disorders.

专利号:US-6593347-B2
优先权日:1998-10-30
标题 :Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use
发明人：BANDARAGE UPUL K; DONG QING; FANG XINQIN; GARVEY DAVID S; MERCER GREGORY J; RICHARDSON STEWART K; SCHROEDER JOSEPH D; WANG TIANSHENG
权利人:NITROMED INC
摘要:The present invention describes novel nitrosated and/or nitrosylated nonsteroidal antiinflammatory compounds, and novel compositions comprising at least one nitrosated and/or nitrosylated nonsteroidal antiinflammatory compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase. The present invention also provides methods for treating, preventing and/or reducing inflammation, pain, and fever; decreasing or reversing the gastrointestinal, renal and other toxicities resulting from the use of nonsteroidal antiinflammatory drugs; treating and/or preventing gastrointestinal disorders; treating inflammatory disease states and disorders; and treating and/or preventing ophthalmic diseases or disorders.

专利号:US-5852198-A
优先权日:1996-04-03
标题 :Wittig reagents and method for preparing α,β-unsaturated phosphonates
发明人：XU YIBO; FLAVIN MICHAEL T; XU ZE-QI
权利人:MEDICHEM RES INC
摘要:Wittig-type reagents and methods of preparation and use thereof for preparing alpha , beta -unsaturated phosphonate esters from aldehydes and ketones are disclosed. The Wittig-type reagents have the following formulae: I II wherein X represents triflate, halide, BF4, SbF6, or ClO4; R1 represents alkyl, aryl or arylalkyl; and R2 represents alkyl, aryl or arylalkyl, provided that R1 and R2 not represent phenyl at the same time. The Wittig reagent diethyl phosphono-methylidenetriphenylphosphorane (1b) has been successfully synthesized for the first time via its phosphonium triflate salt (4a), by treating diethyl phosphonomethyltriflate with triphenylphosphine according to the disclosed method. The procedure has been applied to the synthesis of other new Wittig-type reagents such as phosphoranes and phosphonium salts. The new Wittig reagents thus synthesized were treated with various aldehydes and an activated ketone, affording the corresponding alpha , beta -unsaturated phosphonates, saturated phosphonates or phosphoric acids. Triphenylphosphorane 1b and triphenylphosphonium 4a led to both cis and trans isomers with the latter being predominant, while trans isomers were almost exclusively formed when tributyl reagents (1c and 4d) were used.

专利号:US-6320040-B1
优先权日:1990-07-27
标题:4-desmethyl nucleoside analogs and oligomers thereof
发明人：COOK PHILLIP DAN; TENG KELLY
权利人:ISIS PHARMACEUTICALS INC
摘要:Tetrahydrofuranyl compounds are provided that are functionalized to include pendant conjugate groups, and which are useful in diagnosis assays and as research reagents. Novel intermediates for the synthesis of the compounds are also provided.

专利号:US-4536355-A
优先权日:1982-10-08
标题 :Phenoxyphenylaminoalkylphosphinates useful in weed control
发明人：LEE SHY-FUH; HENRICK CLIVE A
权利人:ZOECON CORP
摘要:Novel phenoxyphenoxyalkyl-, phenoxyphenylthioalkyl- or phenoxyphenylsulfonylalkyl-substituted phosphinates and phosphonates, related compounds, synthesis thereof, intermediates therefor, and the use of said novel compounds for the control of weeds.

专利号:US-4456464-A
优先权日:1982-05-19
标题 :Phenoxy- and pyridyloxy-phenoxyalkyl phosphinates and related sulfur compounds for weed control
发明人：LEE SHY-FUH; HENRICK CLIVE A
权利人:ZOECON CORP
摘要:Novel phenoxyphenoxyalkyl-, phenoxyphenylthioalkyl- or phenoxyphenylsulfonylalkyl-substituted phosphinates and phosphonates, related compounds, synthesis thereof, intermediates therefor, and the use of said novel compounds for the control of weeds.