CAS: 171752-68-4; (1R,3R)-Methyl 1-(Benzo[d][1,3]Dioxol-5-yl)-2,3,4,9-Tetrahydro-1H-Pyrido[3,4-B]Indole-3-Carboxylate Hydrochloride

D-色氨酸置于氯化亚砜,碳酸二甲酯体系中,化学反应 22.0H,反应生成(1R,3R)-9H-吡啶并[3,4-B]吲哚-3-羧酸,1,2,3,4-四氢-1-(3,4-亚甲基二氧基苯基)甲酯盐酸盐
参考文献:Improved Synthesis Of Tadalafil Using Dimethyl Carbonate And Ionic Liquids
标题:Improved Synthesis Of Tadalafil Using Dimethyl Carbonate And Ionic Liquids
摘要:一种改进的他达拉非合成方法,该药用于治疗男性勃起功能障碍,采用了更安全的溶剂和试剂,并减少了合成步骤的数量.
Doi:10.1039/c3Ra45982A

专利信息

专利号:US-2011105751-A1
优先权日:2008-03-31
标题:Conversion of tryptophan into beta-carboline derivatives
发明人：PIRC SAMO
权利人:LEAK PHARMACEUTICALS D D
摘要:The invention belongs in the field of organic chemistry and relates to a new shortened Pictet-Spengler type reaction for preparing isomerically pure β-carboline compounds useful for the synthesis of tadalafil.