CAS: 15571-48-9; ——

上下游产品

magnesium methanolate isopropyl alcohol magnesium ethylate aluminum isopropoxide9-(2-hydroxyethyl)adenine (1+)*(C2H5)2O=Mg((C2H5)2O)(1+)Mg(1+)*(C2H5)2O=Mg((C2H5)2O)(1+) isopropyl alcohol (1+)(n-BuOH)Mg(1+)(n-BuOH)

专利信息

专利号:US-10155007-B2
优先权日:2014-10-29
标 题:Synthesis method for improved tenofovir disoproxil fumarate using ion-exchange resin and method for preparing oral dissolving film form using the same
发明人：KIM DONG-JIN; KOO CHANG-HUI; CHO IL-HEE; LEE SUNG-BAE; HAN DONG-HOON
权利人:FIRSON
摘要:The present invention relates to a synthesis method of preventing the formation of impurities and byproducts in the synthesis of tenofovir disoproxil fumarate (Teno-DF) used as a medicine for hepatitis B and HIV treatment due to its function to promote bioactivities. In the synthesis method of the present invention, an ion-exchange resin (Dowex 50W hydrogen form, sulfonic acidic cation exchange resin) is used to enhance the yield and purity of the compound. The present invention also relates to a method of preparing an oral dissolving film dosage form in the manufacture of a medicine using the tenofovir compound with high purity obtained by the synthesis method of the present invention as an effective ingredient.

专利号:WO-2011116933-A1
优先权日:2010-03-24
标 题 :Process for the preparation of 2-substituted 4-amino-5-cyanopyrimidines
发明人：DICK VIKTOR; HANSELMANN PAUL; KRAMER RAINER; LADNAK VIKTOR
权利人:LONZA AG; DICK VIKTOR; HANSELMANN PAUL; KRAMER RAINER; LADNAK VIKTOR
摘要:A compound of the formula (I), wherein R 1 is C 1-4 alkyl or phenyl, is prepared by reacting a dicyanomethanide of the formula: M r n + [CH(CN) 2 ] rÌ… n (II), wherein M is an alkali or alkaline earth metal and r is 1 or 2, with carbon monoxide to obtain a dicyanoethenolate of the formula: M r n + [(NC) 2 C=CH–O] rÌ… (III), which is acylated to obtain an acyloxymethylenemalononitrile of the formula: (NC) 2 C=CH–OCOR 2 (IV), wherein R 2 is C 1-4 alkyl, which in turn is reacted with an amidine of the formula (V) to obtain the 4-amino-5-cyanopyrimidine of the formula (I). The compound of formula (I), wherein R is methyl, is an intermediate in a synthesis of thiamin (vitamin B 1 ).

专利号:US-RE36718-E
优先权日:1993-06-29
标题:Optically active aminoalcohol derivatives and method of producing same
发明人：MITSUDA MASARU; HAYASHI SHIGEO; HASEGAWA JUNZO; UEYAMA NOBORU; OHASHI TAKEHISA; SHIBASAKI MASAKATSU
权利人:KANEKA CORP
摘要:PCT No. PCT/JP94/01049 Sec. 371 Date Jun. 21, 1995 Sec. 102(e) Date Jun. 21, 1995 PCT Filed Jun. 29, 1994 PCT Pub. No. WO95/01323 PCT Pub. Date Jan. 12, 1995An object of the present invention is to provide a safe method of commercially producing optically active aminoalcohol derivatives, which serve as intermediates for the synthesis of medicinal chemicals such as the immunopotentiating anticancer agent bestatin, in a simple and easy manner in high yields and with high levels of selectivity. The present invention consists in a method of producing 3-amino-1-nitro-4-phenyl-2-butanol derivatives of the general formula (1) wherein R1 and R2 each independently represents a hydrogen atom or an amino group protecting group, and a method of producing 3-amino-2-hydroxy-4-phenylbutyric acid derivatives derivable therefrom.

专利号:US-4609755-A
优先权日:1983-10-20
标题 :Synthesis of vinyl esters
发明人：FARRAR DAVID
权利人:ALLIED COLLOIDS LTD
摘要:An ester interchange process, preferably for the formation of vinyl higher esters from methyl acrylate or methacrylate, is conducted in the presence of a novel alcoholate of the formula [M1(OR4)2-aRa6]x[M2(OR4)n-bRb6]y I wherein M1 is selected from Mg, Ca and Ba M2 is selected from Ti, Zr and Al n is 3 or 4 and is the valency of M2 a is a number from 0 to 1.5 b is a number from 0 to 0.75n x+Y=1 and each is a number from 0.005 to 0.995 and is such that the compound is liquid at 30 DEG 0 C. R4 is selected from alkyl having at least 4 carbon atoms, cycloalkyl having at least 4 carbon atoms and aminoalkyl, and each group R6 is individually selected from C1-3 alkoxy and blocking groups that are substantially less reactive in the ester interchange reaction than the groups OR4.

专利号:US-5521263-A
优先权日:1994-10-18
标 题:Catalysts and synthesis of high molecular weight amorphous polyolefins and recovery thereof
发明人：SEEGER HORST K; HOLLIDAY ROBERT E
权利人:EASTMAN CHEM CO
摘要:A process for the production of amorphous polyolefins is disclosed. The process entails contacting the olefin monomer, in an unreactive hydrocarbon solvent, with a catalyst in a recirculated, stirred reactor thereby producing amorphous polyolefin. The reactor is capable of recirculating contents that are very viscous.

专利号:US-2022289684-A1
优先权日:2019-08-29
标 题:Benzimidazole substitution-based phenyl n-butyramide compound and preparation method therefor
发明人：SHEN JINGSHAN; SUN CHANGLIANG; ZHU FUQIANG; ZHANG JUNCHI; LI RUI
权利人:TOPHARMAN SHANGHAI CO LTD; SHANGHAI INST OF MATERIAMEDICA CHINESE ACADEMY OF SCIENCES; TOPHARMAN TANCHENG CO LTD
摘要:The present disclosure relates to a benzimidazole-substituted phenyl-n-butyramide-based compound and the preparation method thereof. The method of the present disclosure avoids nitration reaction and polyphosphoric acid cyclization reaction, and avoids the generation of a large amount of waste acid reaction solution from the source. The synthesis method embodied in the invention has the advantages of simplicity and high efficiency, mild conditions and few pollutants, etc., and is suitable to be developed as a green and sustainable production process.