CAS: 13600-47-0; 5-Aminonicotinonitrile

相似化合物

1823811-69-3 24242-19-1 60524-14-3

上下游产品

2-(2-chlorophenyl)ethanamine 3-cyano-5-dimethylaminopyridine 3-cyano-5-ethylaminopyridine

📜2-氯苯乙胺,Propyl 5-Amino-N-Cyano-3-Pyridinecarboximidate 以 甲醇 用作溶剂,化学反应生成3-氰基-5-氨基吡啶
参考文献:Pyridinecarboxyimidamide Compounds And The Use Thereof
标题:Pyridinecarboxyimidamide Compounds And The Use Thereof
摘要:揭示了具有扩血管作用(降压活性或抗心绞痛活性)的吡啶羧酰胺,以及其酸盐加合物.其中,当r.Sup.1代表烷基,羟基烷基,羧基,氨基,酰胺基,烷基氨基,二烷基氨基,芳基烷基氨基,烷基磺酰胺,双烷基磺酰胺基或羟基时,R.Sup.2代表氢原子,R.Sup.3代表亚硝基,2-氯苯基或苯基;当r.Sup.1代表氢原子时,R.Sup.2代表烷基,羟基烷基,羧基,氨基,酰胺基,烷基氨基,二烷基氨基,芳基烷基氨基,烷基磺酰胺,双烷基磺酰胺基或羟基,R.Sup.3代表亚硝基,2-氯苯基或苯基.还揭示了利用式(i)所代表的化合物进行抗高血压或抗心绞痛目的的用途.

专利信息

专利号:US-8981092-B2
优先权日:2008-09-19
标题 :Substituted 3,4-dihydro-2H-pyrrolo[1,2-a]pyrazin-1-ones as modulators of protein kinase activity
发明人：MIRIZZI DANILO; CERVI GIOVANNI; D ANELLO MATTEO; PAPEO GIANLUCA MARIANO ENRICO; FERGUSON RON; CASUSCELLI FRANCESCO
权利人:MIRIZZI DANILO; CERVI GIOVANNI; D ANELLO MATTEO; PAPEO GIANLUCA MARIANO ENRICO; FERGUSON RON; CASUSCELLI FRANCESCO; NERVIANO MEDICAL SCIENCES SRL
摘要:Compounds which are 4,7-disubstituted derivatives of 3,4-dihydro-2H-pyrrolo[1,2-a]pyrazin-1-one compounds, n nor pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, viral infection, prevention of AIDS development in HIV-infected individuals, cell proliferative disorders, autoimmune and neurodegenerative disorders; also disclosed is a process under Solid Phase Synthesis conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.

专利号:US-9815842-B2
优先权日:2014-05-28
标题 :Pyrazolo pyrimidine derivatives and their use as MALT1 inhibitors
发明人：SOLDERMANN CAROLE PISSOT; QUANCARD JEAN; SCHLAPBACH ACHIM; SIMIC OLIVER; TINTELNOT-BLOMLEY MARINA; ZOLLER THOMAS
权利人:SOLDERMANN CAROLE PISSOT; QUANCARD JEAN; SCHLAPBACH ACHIM; SIMIC OLIVER; TINTELNOT-BLOMLEY MARINA; ZOLLER THOMAS; NOVARTIS AG
摘要:The present invention describes new pyrazolo-pyrimidine derivatives which are generally interacting with MALT1 proteolytic and/or autoproteolytic activity, and in particular which may inhibit said activity. The present invention further describes the synthesis of said new pyrazolo-pyrimidine derivatives, their use as a medicament, especially by interacting with MALT1 proteolytic and/or autoproteolytic activity.