CAS: 131438-79-4; Amyloid Beta-Protein (Human, 1-40) Trifluoroacetate

该化合物是一种在阿尔茨海默氏病发病的病原体中起着重要作用的甲状腺素,它通过乙酸酶和伽马酸酶的酶分泌而出自氨基先质蛋白(APP),由40氨基酸组成,是大脑中最普遍的氨基乙酰形式之一.A1-40因其具有综合倾向而闻名,形成寡头和纤维状物,有助于阿耳斯海默体的形成,成为阿耳尔海默病的标志.Peptide是水性恐惧症,影响其聚合行为以及与细胞膜的相互作用.A1-40可诱发...

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    专利号:US-9574189-B2
    优先权日:2005-12-01
    标题:Enzymatic encoding methods for efficient synthesis of large libraries
    发明人:FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK
    权利人:FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK; NUEVOLUTION AS
    摘要:Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).

    专利号:US-11702652-B2
    优先权日:2005-12-01
    标题:Enzymatic encoding methods for efficient synthesis of large libraries

    专利号:US-2009264300-A1
    优先权日:2005-12-01
    标题 :Enzymatic encoding methods for efficient synthesis of large libraries

    专利号:US-2020216836-A1
    优先权日:2005-12-01
    标题 :Enzymatic encoding methods for efficient synthesis of large libraries

    专利号:US-6573276-B2
    优先权日:2001-05-09
    标 题:Muscarinic M1 agonist as an inhibitor of beta-amyloid (Aβ40 and Aβ42)-synthesis
    发明人:HOCK CHRISTOPH; RASCHIG ANDREAS; WIENRICH MARION; NITSCH ROGER; MENDLA KLAUS; MEIER DIETER HORST; BORNEMANN KLAUS; DORNER-CIOSSEK CORNELIA
    权利人:BOEHRINGER INGELHEIM PHARMA
    摘要:Methods of lowering the levels of Aβ 40 , Aβ 42 and tau protein in a mammal comprising administering to the mammal an effective amount of talsaclidine, or a physiologically acceptable acid addition salt thereof, and methods of treating diseases associated with the formation of diffuse and senile plaques or Aβ 40 -, Aβ 42 - and tau-containing plaques are disclosed.

    专利号:EP-1957644-B1
    优先权日:2005-12-01
    标 题 :Enzymatic encoding methods for efficient synthesis of large libraries

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    合成参考文献


    参考文献:10.1021/jf60205a057
    摘要:Wu CH, Nakai S, Powrie WD. Preparation and properties of acid-solubilized gluten. J Agric Food Chem. 1976 May;24(3):504–10. doi: 10.1021/jf60205a057.
    参考文献:10.1016/s0021-9258(17)33192-7
    摘要:Chen MS, Ward DC, Prusoff WH. 5-Iodo-5'-amino-2',5'-dideoxyuridine-5'-N'-triphosphate. Synthesis, chemical properties, and effect on Escherichia coli thymidine kinase activity. Journal of Biological Chemistry. 1976 Aug;251(16):4839–42. doi: 10.1016/s0021-9258(17)33192-7.
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