合成目标产物 Benzophenone 主要起始原料 Benzonitrile And Phenylboronic Acid
76-83-5 = 119-61-9 + 76-84-6 + 968-39-8 反应条件:1.1 Reagents: Oxygen Solvents: Tert-Butylbenzene1.2 Reagents: Sodium Ethoxide 标题:Single Electron Transfer Initiated Thermal Reactions Of Arylmethyl Halides. Part 14. The Reaction Of Triphenylmethyl Halides With Tributylphosphine And Tributylamine In Apolar Solvents 作者:Huszthy,Peter; Izso Gergacz,Gyongyi; Lempert,Karoly; Kajtar-Peredy,Maria; Gyor,Miklos; Et Al 参考文献:Journal Of The Chemical Society 日期:1989 卷标:(1989) 页码:1513-20]
2983125-18-2 = 119-61-9 + 2103741-86-0 反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Tetrahydrofuran,Water; Rt1.2 Reagents: Sodium Bicarbonate Solvents: Water; Rt 标题:Unlocking New Prenylation Modes: Azaindoles As A New Substrate Class For Indole Prenyltransferases 作者:Gardner,Eric D.; Johnson,Bryce P.; Dimas,Dustin A.; Mcclurg,Heather E.; Severance,Zachary C.; Et Al 参考文献:Chemcatchem 日期:2023 卷标:15(19)]
= 119-61-9 + 85068-36-6 反应条件:1.1 Reagents: Bromobenzene,Cesium Carbonate Catalysts: Triphenylphosphine,Palladium Diacetate Solvents: O-Xylene; 16 H,150 °C; 150 °C -> Rt1.2 Reagents: Hydrochloric Acid Solvents: Water 标题:Steric And Electronic Effects Influencing β-Aryl Elimination In The Pd-Catalyzed Carbon-Carbon Single Bond Activation Of Triarylmethanols 作者:Bour,James R.; Green,Jacob C.; Winton,Valerie J.; Johnson,Jeffrey B. 参考文献:Journal Of Organic Chemistry 日期:2013 卷标:78(4) 页码:1665-1669]
3060-50-2 + 333-60-8 = 119-61-9 + 84277-81-6 反应条件:1.1 Reagents: Acetic Acid Catalysts: 3-Pyridinol,4-(Aminomethyl)-6-Methyl-5-[2-[(Methylamino)Methyl]-1-Naphthalenyl]... Solvents: Methanol,Water; 20 H,Rt 标题:Enzyme-Inspired Axially Chiral Pyridoxamines Armed With A Cooperative Lateral Amine Chain For Enantioselective Biomimetic Transamination 作者:Liu,Yong Ethan; Lu,Zhaole; Li,Bo; Tian,Jiaxin; Liu,Feng; Et Al 参考文献:Journal Of The American Chemical Society 日期:2016 卷标:138(34) 页码:10730-10733]
专利号:US-6531591-B1 优先权日:1999-07-07 标 题 :Synthesis of stable quinone and photoreactive ketone phosphoramidite reagents for solid phase synthesis of photoreactive-oligomer conjugates 发明人:FENSHOLDT JEF 权利人:EXIQON AS 摘要:Quinone phosphoramidite reagents as well as photoreactive ketone phosphoramidite reagents, such as anthraquinone phosphoramidite reagents and benzophenone phosphoramidite reagents were synthesized and used for the solid phase synthesis of photoreactive-oligonucleotide conjugates. These phosphoramidite reagents are stable, suitable for large-scale synthesis and designed for automated solid phase synthesis of oligomers terminating in a photoreactive moiety.
专利号:US-6515039-B1 优先权日:1998-08-28 标 题:Method for the parallel and combinatory synthesis of compounds bound to a continuous polymeric solid phase supporting material 发明人:ULBRICHT MATHIAS; VOLKMER-ENGERT RUDOLF; GERMEROTH LOTHAR; WENSCHUH HOLGER 权利人:POLY AN GMBH 摘要:The invention relates to a method for the parallel and combinatory synthesis of compounds bound to a continuous polymeric solid phase supporting material. According to the method, a continuous polymeric solid phase supporting material is prepared, the material comprising a matrix of a supporting polymeric material and graft copolymer chains covalently bound to the supporting matrix, the graft copolymer chains having reactive groups being able to react with organic compounds, thereby forming spatially defined reaction sites. The method then comprises the sequential spotting of synthesis building blocks or reagents at the various reaction sites on the continuous solid phase supporting material to yield a substrate library of compounds bound to the solid phase supporting material, whereby each reaction site on the continuous solid phase supporting material determines the composition of the synthesized compound, which is bound directly on the supporting matrix via the reactive groups of the graft polymer chain.
专利号:EP-1202998-B1 优先权日:1999-07-07 标 题 :Synthesis of stable quinone and photoreactive ketone phosphoramidite reagents for solid phase synthesis of photoreactive-oligomer conjugates 发明人:FENSHOLDT JEF 权利人:EXIQON AS 摘要:Quinone phosphoramidite reagents as well as photoreactive ketone phosphoramidite reagents, such as anthraquinone phosphoramidite reagents and benzophenone phosphoramidite reagents were synthesized and used for the solid phase synthesis of photoreactive-oligonucleotide conjugates. These phosphoramidite reagents are stable, suitable for large-scale synthesis and designed for automated solid phase synthesis of oligomers terminating in a photoreactive moiety.
专利号:US-5549974-A 优先权日:1994-06-23 标题:Methods for the solid phase synthesis of thiazolidinones, metathiazanones, and derivatives thereof 发明人:HOLMES CHRISTOPHER P 权利人:AFFYMAX TECH NV 摘要:The invention provides an efficient and versatile method for the combinatorial synthesis and screening of libraries of 4-thiazolidinones, metathiazanones, and derivatives thereof. In order to expediently synthesize a combinatorial library of derivatives based upon these core structures, a general methodology for the solid phase synthesis of these derivatives is also provided. Arrays of thiazolidinones, metathiazanones, and derivatives thereof useful as peptidomimetics and for the identification of agents having antifungal, antihistaminic, or antimicrobial activity or use in the treatment of inflammation, hypertension, renal failure, congestive heart failure, uremia and other conditions can be prepared using this method.
专利号:EP-0439404-B1 优先权日:1990-01-25 标题 :Preparation of 2-(2'-thienyl) alkylamines and derivatives thereof and synthesis of 4,5,6,7- thieno [3,2-c] pyridine derivatives therefrom 发明人:KHATRI HIRALAL N; DEHOFF BRADLEY S 权利人:SANOFI SA 摘要:An improved process for the synthesis of 2-(2 min -thienyl)ethylamine from suitably functionalized derivatives of 2-(2 min -thienyl)ethanol employing ammonia gas in the presence of a metal salt or liquid ammonia and alkyl ketone as a solvent. The 2-(2 min -thienyl)ethylamine produced by this process is advantageously converted to the carbamic acid salt, which is suitably reconverted to 2-(2 min -thienyl)ethylamine, a useful intermediate in the synthesis of ticlopidine.
专利号:US-5338851-A 优先权日:1993-03-31 标 题:Synthesis of cis-decahydroisoquinoline-3-carboxylic acids 发明人:HUFF BRET E; KHAU VIEN V; MARTINELLI MICHAEL J; PETERSON BARRY C 权利人:LILLY CO ELI 摘要:This invention provides a process for the synthesis of cis-decahydroisoquinoline-3-carboxylic acids and provides intermediates in the synthesis thereof.
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合成参考文献
参考文献:10.3390/ijms12063422 摘要:Hendra R, Ahmad S, Sukari A, Shukor MY, Oskoueian E. Flavonoid analyses and antimicrobial activity of various parts of Phaleria macrocarpa (Scheff.) Boerl fruit. Int J Mol Sci. 2011;12(6):3422–31. 参考文献:10.1007/978-1-61779-188-8_2 摘要:Gaynor JW, Cosstick R. Dinucleotides containing 3'-S-phosphorothiolate linkages. Methods Mol Biol. 2011;764():17–30. doi: 10.1007/978-1-61779-188-8_2. 参考文献:10.1107/s160053681100969x 摘要:Suchetan PA, Foro S, Gowda BT. 4-Chloro-N-(4-nitro-benzo-yl)benzene-sulfonamide. Acta Crystallogr Sect E Struct Rep Online. 2011 Apr 01;67(Pt 4):o904. 参考文献:10.1107/s1600536811009470|10.1107/s1600536811009846 摘要:Suchetan PA, Foro S, Gowda BT. 2-Methyl-N-(4-nitro-benzo-yl)benzene-sulfonamide. Acta Crystallogr Sect E Struct Rep Online. 2011 Apr 01;67(Pt 4):o929. 参考文献:10.1107/s1600536811009913 摘要:Suchetan PA, Foro S, Gowda BT. 2-Chloro-N-(4-nitro-benzo-yl)benzene-sulfonamide. Acta Crystallogr Sect E Struct Rep Online. 2011 Apr 01;67(Pt 4):o930.