CAS: 114-42-1; 2-Butanoyl-4-[(3-Butanoyl-2,4,6-Trihydroxy-5-Methylphenyl)Methyl]-3,5-Dihydroxy-6,6-Dimethylcyclohexa-2,4-Dien-1-One

📜间苯三酚甲醛置于盐酸,Aluminum (III) Chloride,锌体系中,用 乙醚,二氯甲烷,水,乙酸乙酯,硝基苯 用作溶剂,化学反应 32.67H,反应生成2-丁酰基-4-[(3-丁酰基-2,4,6-三羟基-5-甲基苯基)甲基]-3,5-二羟基-6,6-二甲基环己-2,4-二烯-1-酮
参考文献:一种天然产物黄绵马酸bb的全合成新方法
标题:一种天然产物黄绵马酸bb的全合成新方法
摘要:本发明涉及一种天然产物黄绵马酸bb的全合成新方法,属于有机化学技术领域.本发明从经济易得的间苯三酚出发合成了双酰化的间苯三酚,再经碘甲烷对碳环进行双甲基化,脱除单分子酰基得到中间体3;以间苯三酚为原料,经甲酰化得到醛基间苯三酚,还原醛基为甲基,再经酰化得到中间体6;上述两个片段通过eschenmoser's Salt拼合得到黄绵马酸bb.该法以42%的总收率提升了黄绵马酸bb的全合成产率,原料经济易得,操作简单,收率较高,适合放大生产,可为其生物活性研究提供大量原料.

专利信息

专利号:CN-108997099-A
优先权日:2018-07-23
标 题:A new method for the total synthesis of natural product fumaric acid BB

专利号:WO-9102040-A1
优先权日:1989-08-04
标 题:Cyclodextrin labels for nucleic acid and biochemical analysis
发明人：KOSAK KENNETH M
权利人:KOSAK KENNETH M
摘要:This invention provides a method of qualitative and quantitative nucleic acid sequence analysis using luminescent cyclodextrin (CD), labels for dideoxy-nucleotide chain terminators and oligonucleotide primers. The CD labels are nonradioactive and detected in a ''black'' background, avoiding problems of fluorescence and allowing more sensitivity. Through formation of inclusion complexes with various fluorophores, the CD labels provide the versatility of different colored labels, with potentially higher signal efficiency in aqueous solutions. The CD labels have similar structures and thereby provide simplicity of synthesis and use, with more uniform chemical/physical properties, even with different colored labels. The invention is intended for high volume nucleic sequencing employing photomultipliers or charge-coupled device cameras for detection. Through the combination of these features, this invention provides advantages of speed, sensitivity, simplicity and versatility previously unknown or suggested in the art of nucleic acid sequence analysis.