CAS: 114-25-0; Biliverdin

该化合物是因 heme 氧化性裂痕而生成的线性四色罗素化合物,是Bilirubin生物合成的关键中间体,在生化研究和工业工艺中具有显著应用.这种技术级产品具有高纯度和稳定性的特点,适合用于酶研究,代谢路径分析,并用作参考标准.它独特的绿色和光谱特性便于在实验环境中识别和量化.Biliverdin还因其光吸附特性,在光动力治疗研究中使用.在惰性条件下的适当储存可以确保长期的储存寿命和持续性能.

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上下游产品

CAS号10035-62-8 胆绿素二甲酯 | CAS号19792-68-8 胆红素二甲酯 | CAS号635-65-4 胆红素 | CAS号19792-68-8 胆红素二甲酯 | CAS号20189-42-8 3-乙基-4-甲基吡咯-2,5-二酮 | CAS号635-65-4 胆红素 | CAS号16568-56-2 中胆红素

合成工艺路线路线简述

    📜胆红素置于bilirubin Oxidase From Magnaporthe Oryzae,氧气体系中,用 Aq. Buffer 用作溶剂,化学反应生成去氢胆红素
    参考文献:Bilirubin Oxidase From Magnaporthe Oryzae And Applications Thereof
    标题:Bilirubin Oxidase From Magnaporthe Oryzae And Applications Thereof
    摘要:本发明涉及一种新型的稻瘟菌胆红素氧化酶,其制备方法以及其应用,特别是用于胆红素测定和酶催化生物燃料电池的应用.

    海关参考信息

    专利信息


    专利号:WO-9410327-A1
    优先权日:1992-10-28
    标 题 :Enzymatic synthesis of polyaniline
    发明人:ZEMEL HAYA; QUINN JOHN F
    权利人:ALLIED SIGNAL INC
    摘要:This invention relates to a process for the enzymatic synthesis of electrically conductive substituted and unsubstituted polyanilines. Aniline monomer(s), an oxidizing agent, which comprises an enzyme and an electron acceptor, and an acidifying agent are reacted together to form polyanilines.

    专利号:US-5420237-A
    优先权日:1991-08-29
    标 题:Enzymatic synthesis of polyaniline
    发明人:ZEMEL HAYA; QUINN JOHN F
    权利人:ALLIED SIGNAL INC
    摘要:This invention relates to a process for the enzymatic synthesis of electrically conductive substituted and unsubstituted polyanilines. Aniline monomer(s), an oxidizing agent, which comprises an enzyme and an electron acceptor, and an acidifying agent are reacted together to form polyanilines.

    专利号:US-2019125694-A1
    优先权日:2016-04-16
    标 题 :Method for treatment of visual stress conditions and compositions used therein
    发明人:JUTURU VIJAYA; DOYLE Lynda; DESHPANDE JAYANT
    权利人:OMNIACTIVE HEALTH TECH LIMITED
    摘要:The methods relate to preventing photoreceptor damage caused by blue light by oral administration of a macular carotenoid composition comprising of lutein and zeaxanthin isomers. The photoreceptor damage is prevented through the upregulation of genes and protein synthesis manifested by an increase in the levels gene expression and proteins synthesis of Gnat1, Rhodopsin, NCAM, Rod arrestin, GAP-43, Nrf2, Ho-1 and decrease in the GFAP, NFkB (oxidative stress markers) in rat eye models exposed to visible blue light for various time periods and simultaneously treated with macular carotenoid compositions comprising of lutein zeaxanthin and their isomers. Methods described herein also relate to treatment of visual stress conditions by administering macular carotenoid compositions for treatment headache, blurred vision, photoreceptor degeneration, oxidative stress, endoplasmic reticulum stress and the like, which are caused due to prolonged exposure to blue light source. The methods described herein help to treat visual stress disorders by reducing headache and headache frequency, slowing down photoreceptor degeneration, improvement in oxidative stress and protection of retinal cells from light damage. The compositions herein are safe for humans and other animals for consumption and can be used for treatment of visual stress disorders in the subject in need thereof.

    专利号:EP-1382327-A1
    优先权日:2002-07-17
    标 题 :Method of protection of the skin against ageing
    发明人:DANOUX LOUIS; FREIS OLGA; PAULY GILLES
    权利人:COGNIS FRANCE SA
    摘要:A method for the production of means for the stimulation of human is proposednSkin cells as well as to protect against skin aging and damaging influencesnEnvironmental toxins and UV radiation, characterized in that the means at least onenSubstance containing the synthesis of energy donors of the mitochondrial respiratory chainnincreases while at the same time the rate of reactive oxygen species (ROS) innCell metabolism lowers.n n n Furthermore, the use of cosmetic and / or pharmaceutical preparations,ncontaining at least one substance which the synthesis of energy donorsnthe mitochondrial respiratory chain increases while at the same time the rate of reactive oxygen speciesn(ROS) in cell metabolism, to stimulate human skin cellsnas well as to the protection against skin aging and damaging influences by environmental poisons andnUV radiation proposed.

    专利号:WO-2022173135-A1
    优先权日:2021-02-10
    标题:Recombinant microorganism with improved production capacity of heme, coproporphyrin â…², uroporphyrin â…², zinc-coproporphyrin â…², zinc-uroporphyrin â…², and biliverdin, and method for production of heme, coproporphyrin â…², uroporphyrin â…², zinc-coproporphyrin â…², zinc-uroporphyrin â…², and biliverdin by using same
    发明人:HAN SUNG OK; KO YOUNG JIN
    权利人:UNIV KOREA RES & BUS FOUND
    摘要:The present invention relates to a recombinant microorganism with improved production capability of heme, coproporphyrin â…¢, uroporphyrin â…¢, zinc-coproporphyrin â…¢ (Zn-coproporphyrin â…¢), zinc-uroporphyrin â…¢ (Zn-uroporphyrin â…¢), and biliverdin, a preparation method therefor, and a method for production of heme, coproporphyrin â…¢, uroporphyrin â…¢, zinc-coproporphyrin â…¢, zinc-uroporphyrin â…¢, and biliverdin by using same. In the present invention, a synergistic effect of the introduction of genes related to the C4 and C5 pathways for synthesis of 5-aminolevulinic acid (ALA), genes related to the coproporphyrin â…¢-dependent pathway, and transcriptional regulatory factors was first evidenced through the improved porphyrin productivity effect of the recombinant microorganism. In addition, in contrast to the conventional recombinant microorganisms which are induced for extracellular production by introducing an extracellular secretion protein thereinto, the present invention first identified that the extracellular secretion of heme can be remarkably increased through the strategy of modifying microorganism cell walls. The recombinant microorganism according to the present invention is provided with enhanced production capability of porphyrin-based materials through the aforementioned metabolism engineering strategy and exhibits high productivity therefor. Thus, heme, coproporphyrin â…¢, uroporphyrin â…¢, zinc-coproporphyrin â…¢, zinc-uroporphyrin â…¢, and biliverdin, which are all high value-added materials, can be economically and efficiently produced by using the recombinant microorganism of the present invention.

    专利号:EP-1406599-B1
    优先权日:2001-07-07
    标 题 :Cosmetic and dermatological preparations containing creatine for treating and actively preventing dry skin and other negative alterations of the physiological homeostasis of healthy skin
    发明人:SAUERMANN GERHARD; SCHREINER VOLKER; DOERING THOMAS; SIEFKEN WILFRIED; GATERMAN CORNELIA; CARSTENSEN STEFANIE; BIERGIESSER HELGA; BLATT THOMAS
    权利人:BEIERSDORF AG
    摘要:Topical compositions containing creatine and its precursors and derivatives, are used to improve skin condition and to treat or prevent skin disorders, abnormal lipid peroxidation, reduced cell-cell communication, deficient intracellular DNA synthesis, DNA damage, deficient DNA repair, abnormal post-translational modification of connective tissue components and dandruff. Topical compositions comprising creatine and its precursors and derivatives and optionally electrolytes, polyols, urea and osmolytes are used: (1) to treat or prevent dry skin, to enhance the barrier function of the skin, for treatment, care and prophylaxis of sensitive skin and/or for treatment and prophylaxis of symptoms of a negative change in the physiological homeostasis of normal skin; (2) to treat or prevent inflammatory skin conditions, atopic eczema, polymorphic photodermatitis, psoriasis, vitiligo and sensitive, itching or irritated skin; (3) to treat or prevent abnormal lipid peroxidation; (4) to treat or prevent abnormal ceramide, lipid and energy metabolism of the skin, abnormal transepidermal water loss, reduced skin hydration and moisture content and altered Natural Moisturizing Factor content; (5) to treat or prevent reduced cell-cell communication, deficient intracellular DNA synthesis, DNA damage, reduced endogenous DNA repair, activation of metalloproteinases and/or other proteases or inhibition of corresponding DNA repair mechanisms and abnormal post-translational modification of connective tissue components; (6) to treat or prevent abnormal skin hyaluronic acid and glucosaminoglycan content; and (7) to treat or prevent dandruff of the hair and scalp and skin aging.

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    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:S55 | ZINC15PHARMA | Pharmaceuticals from ZINC15 | DOI:10.5281/zenodo.3247749
    摘要:C. H. Gray, A. Kulezycka, and D. C. Nicholson. J. Chem. Soc. 1961, 2276.
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