CAS: 112822-85-2; 2,4,5-Trifluoro-3-Methylbenzoic Acid

相似化合物

1003709-96-3 112857-68-8 446-17-3

上下游产品

2,4,5-三氟苯甲酸 2,4,5-Trifluorobenzoic Acid 446-17-3
2,4,5-Trifluoro-3-Methylbenzamide 112822-84-1
2-(2,5,6-三氟-3,4-二羧基苯基)-乙酸 2-(2,5,6-Trifluoro-3,4-Dicarboxyphenyl)-Acetic Acid 181942-10-9

2-(2,5,6-三氟-3,4-二羧基苯基)-乙酸 以 二甲基亚砜 用作溶剂,以to Give 3-Methyl-2,4,5-Trifluorobenzoic Acid的收率获得2,4,5-三氟-3-甲基苯甲酸
参考文献:Pyridonecarboxylic Acid Derivatives Substituted By A Bicyclic Amino
标题:Pyridonecarboxylic Acid Derivatives Substituted By A Bicyclic Amino
摘要:本发明涉及一种由以下式(i)表示的n.Sub.1-(卤代环丙基)-取代吡啶酮羧酸衍生物:##str1## 其中x.Sup.1是卤素原子或氢原子;X.Sup.2是卤素原子;R.Sup.1是氢原子,羟基,硫醇基,卤代甲基基团,氨基,烷基或可能具有取代基的烷氧基;R.Sup.2是由以下式(II)表示的基团:##str2## 其中r.Sup.3和r.Sup.4独立地是氢原子或烷基,N是1或2的整数;A是氮原子或以下式(III)的部分结构:##str3## 其中x.Sup.3是氢原子,卤素原子,氰基,氨基,烷基,卤代甲基基团,烷氧基或卤代甲氧基基团,可能具有取代基;而r是氢原子,苯基,乙酰氧甲基基团,季戊酰氧甲基基团,乙氧羰基基团,胆碱基团,二甲氨基乙基基团,5-吲哚基基团,邻苯二甲酰基基团,5-烷基-2-氧代-1,3-二氧杂环戊-4-基甲基基团,3-乙酰氧基-2-氧代丁基基团,烷基,烷氧基甲基基团或苯基烷基基团,并提供一种作为抗菌药物有用的杂环化合物.

专利信息

专利号:US-7109377-B2
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
发明人：SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R
权利人:HARVARD COLLEGE
摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.

专利号:US-6448443-B1
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products