CAS: 87026-45-7; 4-Chloro-5-Methoxy-2-(Methylthio)Pyrimidine

该化合物是一种多用途的微米碘衍生物,广泛用作制药和农用化学合成的关键中间体,其活性化的氯和甲基硫化物组得以高效功能化,使其对构建复杂的七环化合物具有价值. 甲氧替代物会增强稳定性并影响电子特性,有利于选择性的修改. 由于其定义明确的再活性特征,该化合物在开发活性药物成分和作物保护剂方面特别有用. 高纯度和一贯的质量可以确保交叉反应,核细胞替代和其他转化的可靠性能. 其结构特征使得研究人员更愿意选择在合成路径上进行精确控制.

结构式图片

相似化合物

49668-65-7 695-85-2 5018-38-2

物理性质

MSDS等安全信息

上下游产品

5-Methoxy-2-methylthiopyrimidin-4(3H)-one 5-Methoxy-2-methylthiopyrimidin-4(3H)-one 5-Methoxy-2-methylthiopyrimidine 2-Hydroxy-5-methoxypyrimidin

合成工艺路线路线简述

  • 109-94-4 + 2986-19-8 = 87026-45-7
    反应条件:1.1 Reagents: Sodium Solvents: Diethyl Ether; 0 °C; 4 H,Rt1.2 Reagents: Water; Cooled1.3 Reagents: Potassium Hydroxide; 40 Min,Rt; 1 H,Rt -> 65 °C; Cooled1.4 Reagents: Hydrochloric Acid Solvents: Water; Neutralized2.1 Reagents: Phosphorus Oxychloride; 0 °C; 1 H,0 °C -> 80 °C; 80 °C -> Rt2.2 Reagents: Ammonia Solvents: Water; Neutralized,Rt
    标题:Synthesis And Antitumor Activity Of Novel N-Benzoyl-N'-Substituted Pyrimidinyl (Thio)Semicarbazide Derivatives
    作者:Song,Gaopeng; Et Al
    参考文献:Letters In Drug Design & Discovery 日期:2016 卷标:13(4) 页码:329-334]

    109-94-4 = 87026-45-7
    反应条件:1.1 Reagents: Sodium Solvents: Methanol2.1 -3.1 Reagents: Phosphorus Oxychloride
    标题:Design,Synthesis And Biological Activities Evaluation Of N-(Substituted Benzoyl)-N'-4,7-Dimethoxy-[1,2,4]Triazolo[1,5-C]Pyrimidine (Thio) Ureas
    作者:Wei,Kailun; Et Al
    参考文献:Youji Huaxue 日期:2020 卷标:40(7) 页码:2127-2134]

    109-94-4 = 87026-45-7
    反应条件:1.1 Reagents: Sodium Solvents: Diethyl Ether; Cooled1.2 Cooled; 4 H,Rt1.3 Reagents: Water; Cooled2.1 Reagents: Potassium Hydroxide Solvents: Water; 40 Min; 1 H,65 °C; Cooled2.2 Reagents: Hydrochloric Acid Solvents: Water; Neutralized3.1 Reagents: Phosphorus Oxychloride; Cooled; 1 H,80 °C; Cooled3.2 Reagents: Ammonia Solvents: Water; Neutralized,Cooled
    标题:Design,Synthesis And Biological Activities Of N-(Substituted Benzoyl)-N'-(5-Methoxyl-2-Methylsulfanylpyrimidin-4-Amino)(Thio)Ureas
    作者:Li,Chengkun; Et Al
    参考文献:Youji Huaxue 日期:2014 卷标:34(11) 页码:2296-2303]

    1671-08-5 = 87026-45-7
    反应条件:1.1 Reagents: Phosphorus Oxychloride; 0 °C; 1 H,0 °C -> 80 °C; 80 °C -> Rt1.2 Reagents: Ammonia Solvents: Water; Neutralized,Rt
    标题:Synthesis And Antitumor Activity Of Novel N-Benzoyl-N'-Substituted Pyrimidinyl (Thio)Semicarbazide Derivatives
    作者:Song,Gaopeng; Et Al
    参考文献:Letters In Drug Design & Discovery 日期:2016 卷标:13(4) 页码:329-334]

    1671-08-5 = 87026-45-7
    反应条件:1.1 Reagents: Phosphorus Oxychloride; Cooled; 1 H,80 °C; Cooled1.2 Reagents: Ammonia Solvents: Water; Neutralized,Cooled
    标题:Design,Synthesis And Biological Activities Of N-(Substituted Benzoyl)-N'-(5-Methoxyl-2-Methylsulfanylpyrimidin-4-Amino)(Thio)Ureas
    作者:Li,Chengkun; Et Al
    参考文献:Youji Huaxue 日期:2014 卷标:34(11) 页码:2296-2303]

    2986-19-8 + 104151-54-4 = 87026-45-7
    反应条件:1.1 -2.1 Reagents: Phosphorus Oxychloride
    标题:Design,Synthesis And Biological Activities Evaluation Of N-(Substituted Benzoyl)-N'-4,7-Dimethoxy-[1,2,4]Triazolo[1,5-C]Pyrimidine (Thio) Ureas
    作者:Wei,Kailun; Et Al
    参考文献:Youji Huaxue 日期:2020 卷标:40(7) 页码:2127-2134]

    2986-19-8 + 104151-54-4 = 87026-45-7
    反应条件:1.1 Reagents: Potassium Hydroxide; 40 Min,Rt; 1 H,Rt -> 65 °C; Cooled1.2 Reagents: Hydrochloric Acid Solvents: Water; Neutralized2.1 Reagents: Phosphorus Oxychloride; 0 °C; 1 H,0 °C -> 80 °C; 80 °C -> Rt2.2 Reagents: Ammonia Solvents: Water; Neutralized,Rt
    标题:Synthesis And Antitumor Activity Of Novel N-Benzoyl-N'-Substituted Pyrimidinyl (Thio)Semicarbazide Derivatives
    作者:Song,Gaopeng; Et Al
    参考文献:Letters In Drug Design & Discovery 日期:2016 卷标:13(4) 页码:329-334]

    2986-19-8 + 104151-54-4 = 87026-45-7
    反应条件:1.1 Reagents: Potassium Hydroxide Solvents: Water; 40 Min; 1 H,65 °C; Cooled1.2 Reagents: Hydrochloric Acid Solvents: Water; Neutralized2.1 Reagents: Phosphorus Oxychloride; Cooled; 1 H,80 °C; Cooled2.2 Reagents: Ammonia Solvents: Water; Neutralized,Cooled
    标题:Design,Synthesis And Biological Activities Of N-(Substituted Benzoyl)-N'-(5-Methoxyl-2-Methylsulfanylpyrimidin-4-Amino)(Thio)Ureas
    作者:Li,Chengkun; Et Al
    参考文献:Youji Huaxue 日期:2014 卷标:34(11) 页码:2296-2303]

    109-94-4 + 2986-19-8 = 87026-45-7
    反应条件:1.1 Reagents: Sodium Solvents: Diethyl Ether; Cooled1.2 Cooled; 4 H,Rt1.3 Reagents: Water; Cooled1.4 Reagents: Potassium Hydroxide Solvents: Water; 40 Min; 1 H,65 °C; Cooled1.5 Reagents: Hydrochloric Acid Solvents: Water; Neutralized2.1 Reagents: Phosphorus Oxychloride; Cooled; 1 H,80 °C; Cooled2.2 Reagents: Ammonia Solvents: Water; Neutralized,Cooled
    标题:Design,Synthesis And Biological Activities Of N-(Substituted Benzoyl)-N'-(5-Methoxyl-2-Methylsulfanylpyrimidin-4-Amino)(Thio)Ureas
    作者:Li,Chengkun; Et Al
    参考文献:Youji Huaxue 日期:2014 卷标:34(11) 页码:2296-2303]

    109-94-4 = 87026-45-7
    反应条件:1.1 Reagents: Sodium Solvents: Diethyl Ether; 0 °C; 4 H,Rt1.2 Reagents: Water; Cooled2.1 Reagents: Potassium Hydroxide; 40 Min,Rt; 1 H,Rt -> 65 °C; Cooled2.2 Reagents: Hydrochloric Acid Solvents: Water; Neutralized3.1 Reagents: Phosphorus Oxychloride; 0 °C; 1 H,0 °C -> 80 °C; 80 °C -> Rt3.2 Reagents: Ammonia Solvents: Water; Neutralized,Rt
    标题:Synthesis And Antitumor Activity Of Novel N-Benzoyl-N'-Substituted Pyrimidinyl (Thio)Semicarbazide Derivatives
    作者:Song,Gaopeng; Et Al
    参考文献:Letters In Drug Design & Discovery 日期:2016 卷标:13(4) 页码:329-334
📜5-甲氧基-2-甲硫基嘧啶-4-醇置于n,N-二甲基苯胺,三氯氧磷体系中,化学反应 2.0H,以87%的收率获得产物5-甲氧基-2-甲硫基-4-氯嘧啶
参考文献:使用二苯基碘鎓盐对嘧啶酮进行苯甲酰化
标题:使用二苯基碘鎓盐对嘧啶酮进行苯甲酰化
摘要:已在碱性条件下使用二苯基碘鎓盐将嘧啶酮1苯酚化,并研究了取代基对收率和区域化学的影响.
DOI:10.1039/a905519C

海关参考信息

其他信息查阅

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

实用工具

⚠️全国化工行业净网倡议书
📋制造商识别码
📖 海关编码查询
📝MSDS生成器

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

合成参考文献

参考DOI号:10.2174/1570180812666151003002644
📝 需求与反馈
尽可能描述清楚需求与问题信息
×

通知