CAS: 7795-95-1; Octane-1-Sulfonyl Chloride

上下游产品

CAS号111-88-6 1-辛硫醇 | CAS号19942-78-0 硫氰酸辛酯 | CAS号822-27-5 二正辛基二硫 | CAS号69422-58-8 S,S-di°Ctyl dit... | CAS号5324-84-5 1-辛基磺酸钠 | CAS号3944-72-7 辛基磺酸 | CAS号85293-39-6 °Ctylsulfanylme... | CAS号111-83-1 1-溴代正辛烷 | CAS号307-34-6 全氟辛烷 | CAS号307-35-7 全氟辛基磺酰氟 | CAS号423-60-9 全氟辛烷磺酰氯 | CAS号872-05-9 正癸烯 | CAS号111-85-3 氯辛烷 | CAS号629-27-6 1-碘辛烷 | CAS号10307-28-5 methyl °Ctanesu... | CAS号104-72-3 癸基苯 | CAS号2189-60-8 正辛基苯 | CAS号3307-19-5 4-°Ctylanisole

1-辛硫醇置于双氧水,氯化锆(Iv)体系中,用 水,乙腈 作为反应溶剂,化学反应 0.03H,以95%的收率获得产物1-辛烷磺酰氯
参考文献:从硫醇和二硫化物衍生物中新型实用合成磺酰氯
标题:从硫醇和二硫化物衍生物中新型实用合成磺酰氯
摘要:在四氯化锆的存在下,过氧化氢是一种非常有效的试剂,可通过氧化氯化将硫醇和二硫化物衍生物直接氧化转化为相应的高纯度磺酰氯.优异的收率,极短的反应时间,温和的反应条件以及避免使用刺激性试剂是该方法的主要优点.
DOI:10.1055/s-0029-1217989

专利信息

专利号:US-6228988-B1
优先权日:1995-02-24
标题:Synthesis of hydroxamic acid derivatives
发明人：FLOYD CHRISTOPHER DAVID; LEWIS CHRISTOPHER NORMAN
权利人:BRITISH BIOTECH PHARM
摘要:The present invention describes processes for preparing desired synthetic products that comprise a covalently bonded hydroxamic acid group -CONHOH by forming a mixture of a liquid reaction medium and a solid phase reaction product that carries a plurality of moieties of formula (A1) or (B1):where X is a residual, non-hydroxamate partial structure of the desired synthetic product, P1 is hydrogen or an amino-protecting group, P2 is hydrogen or a hydroxyl protecting group, and the bond designated (a) covalently links the moieties (A1) or (B1) to the residue of a solid substrate; by cleaving the bond designated (a) in the resultant mixture; and by separating the resultant liquid reaction phase from the resultant reaction solids to recover the desired synthetic product.

专利号:US-12227522-B2
优先权日:2020-12-21
标题:Synthesis of structural analogs of largazole and associated compounds
发明人：WILLIAMS ROBERT M; KOTI SIVANAGIREDDY; DE SUBHADIP; SHELKE ANIL M; CERBONE RYAN E; YASUDA NOBUYOSHI
权利人:UNIV COLORADO STATE RES FOUND; CETYA THERAPEUTICS INC
摘要:Disclosed are various synthetic methods to prepare structural analogs of largazole and derivatives thereof. One structural analog is an amide isostere of largazole. Another structural analog replaces the thiazole ring of largazole with a pyridine moiety or an oxazole moiety. Also disclosed are various intermediate compounds obtained when preparing structural analogs of largazole and derivatives thereof, including macrocycle analogs having an alcohol functionality.

专利号:US-2005192265-A1
优先权日:2003-03-20
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-6906056-B2
优先权日:1998-06-22
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
权利人:LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-6093798-A
优先权日:1995-02-24
标题 :Synthesis of hydroxamic acid derivatives

专利号:WO-2010115869-A1
优先权日:2009-04-03
标 题 :Propofol phosphonyl derivatives, synthesis, and use in long acting formulations
发明人：GONNISSEN YVES RENE JOHANNA PAUL
权利人:SEPS PHARMA N V; GONNISSEN YVES RENE JOHANNA PAUL
摘要:This invention relates to compounds represented by the structural formula (I), and the salts and stereoisomers thereof, wherein: - L is a linker selected from the group consisting of -(CH 2 ) P -O-, a single bond, formula (IA), -(CH 2 ) 1-8 -O-X(O)-, and - p is an integer from 1 to 8, - each R 3 and each R 4 is independently selected from the group consisting of C 1-20 alkyl, C 3-12 alkyl, C 3-12 cycloalkyl-C 1-4 alkyl, saturated heterocyclyl and saturated heterocyclyl-C 1-4 alkyl, and - X and Y are each independently C or S(O), - Z is selected from the group consisting of O, S(O) and NR 5 , - W is selected from the group consisting of halogen, OH, S(O)H and O - M + wherein M + is a monovalent cation; and - R 5 is selected from the group consisting of hydrogen and C 1-10 alkyl. These compounds are useful pharmaceutical agents with improved oral bioavailability.