CAS: 72648-80-7; Ethyl 2-((2-((Tert-Butoxycarbonyl)Amino)Ethyl)Amino)Acetate

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CAS号57260-73-8 N-叔丁氧羰基-1,2-乙二胺 | CAS号105-36-2 溴乙酸乙酯 | CAS号64805-08-9 ethyl glyoxylat... | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号141743-15-9 Fm°C-N-(2-B°C-氨... | CAS号34046-07-6 Z-(B°C-氨基乙基)-L-甘氨酸 | CAS号90495-99-1 ([2-[(叔丁氧羰基)氨基]...

📜Ethyl-(2-Boc-Amino-Ethylimino)Acetate置于10Percent Pd/c 氢气体系中,用 二氯甲烷 作为反应溶剂,化学反应 4.0H,以98%的收率获得产物n-[2-(叔丁氧羰基氨基)乙基]甘氨酸乙酯盐酸盐
参考文献:N-[(2-Boc-氨基)乙基]甘氨酸乙酯及其盐酸盐的便捷,可扩展合成.肽核酸合成的关键中间体.
标题:N-[(2-Boc-氨基)乙基]甘氨酸乙酯及其盐酸盐的便捷,可扩展合成.肽核酸合成的关键中间体.
摘要:据报道,N-[(2-Boc-氨基)乙基]甘氨酸乙酯及其盐酸盐的合成得到改进.该合成是基于boc-乙二胺与乙醛酸乙酯水合物的还原烷基化,并且无需色谱即可以接近定量的收率和高纯度提供标题化合物.该化合物原样适合于合成肽核酸单体.此外,转化为盐酸盐提供了稳定的,不吸湿的固体,这是用于处理和储存的方便形式.
DOI:10.1021/jo026590W

专利信息

专利号:WO-2004037772-A1
优先权日:2002-10-22
标 题 :Convenient and scalable synthesis of ethyl n-[(2-boc-amino) ethyl] glycinate and its hydrochloride salt
发明人：HUDSON ROBERT H E; VIIRRE RUSSELL D
权利人:UNIV WESTERN ONTARIO; HUDSON ROBERT H E; VIIRRE RUSSELL D
摘要:The present invention discloses an improved synthesis of ethyl N-[(2-Boc-amino)ethyl]glycinate and its hydrochloride salt. The synthesis is based on the reductive alkylation of Boc-ethylenediamine with ethyl glyoxylate hydrate and furnishes the title compound in near quantitative yield and high purity without chromatography. This compound is suitable, as is, for the synthesis peptide nucleic acid monomers. Further, conversion to the hydrochloride salt provides a stable, non-hygroscopic solid that is a convenient form for handling and storage.

专利号:EP-1318142-B1
优先权日:2000-09-05
标题:T-butoxycarbonylaminoethylamine for the synthesis of pna monomer units, amino acid derivatives, intermediates thereof, and processes for productions of them

专利号:EP-1318142-A1
优先权日:2000-09-05
标 题:T-butoxycarbonylaminoethylamine for the synthesis of pna monomer units, amino acid derivatives, intermediates thereof, and processes for productions of them

专利号:EP-1873156-A1
优先权日:1995-06-07
标 题:Process for the preparation of 6-[[(alkoxy)carbonyl]amino]-9H-Purine-9-acetic acid and 4-[(alkoxycarbonyl)amino]-2-oxo-1(2H)-Pyrimidineacetic acid derivatives as synthons for the synthesis of peptide nucleic acids

专利号:US-9598720-B2
优先权日:2005-07-01
标 题 :Monomeric and polymeric linkers useful for conjugating biological molecules and other substances
发明人：LOHSE JESPER
权利人:DAKO DENMARK AS
摘要:The present invention concerns monomeric or polymeric linker molecules useful in biological and chemical applications, their synthesis, and the synthesis and use of derivatives of the linkers conjugated to a variety of detectable labels and other substances. The linkers may be used, for example, in conjunction with fluorescent labels, nucleic acid or nucleic acid analog probes, and solid phase systems, and to enhance the solubility of the conjugated molecules.