CAS: 6973-60-0; 1-Methyl-2-Pyrrolecarboxylic Acid

该化合物是一种有机化合物,其特征是其火花环结构,即五人组成的含有一个氮原子的芳香热循环,该化合物在2位置上有一个碳酸性功能组(-COOH),在1位置于火花环上有一个甲基(-CH3),该化合物一般没有颜色,可粉黄为固体或液体,视其纯度和形态而定. 箱式酸组的存在具有酸性,允许其参与各种化学反应,例如酯化和恐吓.此外,该甲基组有助于该化合物的缺水性特性,影响其在有机溶剂中的溶解性. 1-M-乙--1H-Pyrcry-2-carboxylic酸可用于有机合成,制药和生产其他化学化合物的中间体.其再活性和功能组使其成为开发更复杂的分子过程中一个有价值的建筑块.

结构式图片

相似化合物

37619-24-2 1192-58-1 34884-10-1

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

N-Methylpyrrole ethyl 1-methyl-1H-pyrrole-2-carboxylate 1-methyl-2-pyrrolyllithium carbon dioxidemethyl N-methylpyrrole-2-carboxylate ethyl (1-methyl-1H-pyrrol-2-yl)acetate 1-Methyl-2,4-dinitropyrrole 1-methyl-4-nitropyrrole-2-carboxylic acid methyl ester

合成工艺路线路线简述

    📜1-甲基吡咯-2-甲酸乙酯置于氢氧化钾体系中,化学反应生成 N-甲基-2-吡咯羧酸
    参考文献:Takeda,Journal Of The Agricultural Chemical Society Of Japan,1959,Vol. 23,P. 165,170
    标题:Takeda,Journal Of The Agricultural Chemical Society Of Japan,1959,Vol. 23,P. 165,170

    海关参考信息

    专利信息


    专利号:US-7344863-B2
    优先权日:1998-03-13
    标题:Methods for producing polypeptides through enhanced synthesis of encoding nucleic acid molecules
    发明人:LI WU-BO; JESSEE JOEL A; SCHUSTER DAVID; XIA JIULIN; GEBEYEHU GULILAT
    权利人:INVITROGEN CORP
    摘要:The present invention is directed to compositions and methods for enhancing synthesis of nucleic acid molecules, particularly GC-rich nucleic acid molecules. Specifically, the invention provides compositions comprising one or more nitrogen-containing organic compounds having a formula selected from the group consisting of formula I and formula II (or salts or derivatives thereof), preferably 4-methylmorpholine N-oxide or betaine (carboxymethyltrimethylammonium), and further comprising one or more compounds selected from the group consisting of proline and an N-alkylimidazole compound, and more preferably proline, 1-methylimidazole or 4-methylimidazole. The invention further relates to methods for enhanced, high-fidelity synthesis of nucleic acid molecules, including via amplification (particularly PCR), reverse transcription, and sequencing methods. The invention also relates to nucleic acid molecules synthesized by these methods, to fragments or derivatives thereof, and to vectors and host cells comprising such nucleic acid molecules, fragments, or derivatives. The invention also relates to kits for synthesizing, amplifying, reverse transcribing or sequencing nucleic acid molecules comprising one or more of the compositions of the invention.

    专利号:US-2021107859-A1
    优先权日:2018-04-06
    标题 :A process for the synthesis of carbon labeled organic compounds
    发明人:AUDISIO DAVIDE; CANTAT THIBAULT; DESTRO GIANLUCA
    权利人:COMMISSARIAT ENERGIE ATOMIQUE
    摘要:A process for the synthesis of a carbon labeled organic compound containing a carbon labeled carboxyl group is described. A method of using carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure; a process for manufacturing labeled pharmaceuticals and agrochemicals comprising synthesis of carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure; and a process for producing tracers comprising synthesis of carbon labeled organic compounds containing a carbon labeled carboxyl group according to the present disclosure are also described.

    专利号:US-7138526-B1
    优先权日:1999-06-15
    标 题 :Solid phase synthesis of n,n-disubstituted diazacycloalkylcarboxy derivatives
    发明人:HERPIN TIMOTHY F; MORTON GEORGE C; SALVINO JOSEPH M
    权利人:AVENTIS PHARMA INC
    摘要:A method for the solid phase synthesis of N,N-disubstituted diazacycloalkylcarboxy derivatives of general formula (I) and (II) is claimed. Examples include piperazine-2-carboxamide. The method is applicable to the synthesis or large combinatorial libraries

    专利号:US-6096898-A
    优先权日:1999-10-22
    标 题:One pot synthesis of 1,2,4-triazoles
    发明人:PODHOREZ DAVID E; HULL JR JOHN W; BRADY CHRISTINE H
    权利人:DOW AGROSCIENCES LLC
    摘要:One pot synthesis of 1,2,4-triazoles uses thioimidate intermediate and 1,2-dichloroethane solvent.

    专利号:US-7109377-B2
    优先权日:1996-10-16
    标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
    发明人:SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R
    权利人:HARVARD COLLEGE
    摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.

    专利号:US-4713383-A
    优先权日:1984-10-01
    标 题:Triazoloquinazoline compounds, and their methods of preparation, pharmaceutical compositions, and uses
    发明人:FRANCIS JOHN E; GELOTTE KARL O
    权利人:CIBA GEIGY CORP
    摘要:[1,2,4]triazolo[1,5-c]quinazoline compounds of the formula wherein R1 is optionally substituted phenyl, pyridyl, furyl thienyl, dihydro or tetrahydro furanyl or thienyl, pyranyl, or 0-ribofuranosyl; R2 is hydrogen or lower alkyl; X is oxygen or NR3, R3 is as defined in the claims, and ring A is unsubstituted or substituted as set forth in the claims. The compounds wherein X is N-R3 are especially useful as adenosine antagonists and for the treatment of asthma. The compounds wherein X is oxygen are useful as benzodiazepine antagonists and as intermediates in the synthesis of the compounds wherein X is N-R3.

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    合成参考文献


    摘要:Lubell, W. D.; St-Cyr, D. J.; Dufour-Gallant, J.; Hopewell, R.; Boutard, N.; Kassem, T.; Dörr, A.; Zelli, R., Science of Synthesis Knowledge Updates, (2013) 1, 315.
    摘要:Spitzner, D., Science of Synthesis Knowledge Updates, (2016) 1, 211.
    摘要:Vashchenko, B. V.; Grygorenko, O. O., Science of Synthesis Knowledge Updates, (2021) 3, 410.
    摘要:Ouellet-Du Berger, M.-R.; Paquin, J.-F., Science of Synthesis: Knowledge Updates, (2023) 2, 285.
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