CAS: 60966-36-1; (8S,9S,10R,13S,14S,17R)-17-(1-Hydroxypropan-2-yl)-10,13-Dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-Tetradecahydro-3H-Cyclopenta[a]Phenanthren-3-One

上下游产品

睾酮 Testosterone 58-22-0
二去甲胆烯醛 (20S)-3-Oxopregn-4-Ene-20-Carboxaldehyde 3986-89-8
20-甲酰基孕甾-4-烯-3-酮 20-Formylpregn-4-En-3-One 24254-01-1
雄烯二酮 Androstenedione 63-05-8
(8S,9S,10R,13S,14S,17R)-17-(1-羟基-2-丙基)-10,13-二甲基-6,7,8,9,10,11,12,13,14,15,16,17-十二氢-3H-环戊二烯并[a]菲-3-酮 22-Hydroxy-23,24-Bisnor-1,4-Choladien-3-One 71658-22-5
胆固醇 Cholesterol 57-88-5

📜20-甲酰基孕甾-4-烯-3-酮置于二氧化锰,Sodium Borohydrid体系中,用 甲醇,氯仿 作为反应溶剂,化学反应生成 21-羟基-20-甲基孕甾-4-烯-3-酮
参考文献:Testosterone 5.Alpha.-Reductase Inhibitors
标题:Testosterone 5.Alpha.-Reductase Inhibitors
摘要:下列通式化合物是睾酮5α-还原酶抑制剂,可用于治疗痤疮和油性皮肤:##str1## 其中n为0至4的整数;r.Sub.1为--Coor.Sub.2,--Conr.Sub.3 R.Sub.4,--Cho或--Ch.Sub.2 Or.Sub.5;r.Sub.2为氢,1至4个碳原子的直链或支链低烷基,或苄基;r.Sub.3和r.Sub.4中的每一个为氢或1至4个碳原子的直链或支链低烷基;r.Sub.5为氢,烷基羰基,其中烷基部分具有1至20个碳原子且为直链或支链,苯甲酰基,苯基烷基羰基,其中烷基部分具有1至6个碳原子且为直链或支链,或环烷基羰基,其中环烷基部分具有5至10个碳原子.

专利信息

专利号:US-11479577-B2
优先权日:2016-05-18
标题:Intermediates for the synthesis of bile acid derivatives, in particular of obeticholic acid
发明人：WEYMOUTH-WILSON ALEXANDER; KOMSTA ZOFIA; WALLIS LAURA; EVANS TIMOTHY; DAVIES IEUAN; OTTER CARL; BATCHELOR RHYS
权利人:NZP UK LTD
摘要:The present invention relates to compounds which are intermediates in the synthesis of bile acid derivatives with pharmacological activity. The invention relates to compounds of general formula (I):wherein:, R1, R2, R3, R4, R5, R6 and Y are as defined herein.The compounds are intermediates in the synthesis of synthetic bile acids which are useful in the treatment of conditions such as liver disease. In addition, the invention relates to a method of synthesizing these intermediates and a method of preparing obeticholic acid and obeticholic acid analogues from the compounds of the invention.

专利号:US-10766921-B2
优先权日:2016-05-18
标 题 :Process and intermediates for the 6,7-alpha-epoxidation of steroid 4,6-dienes
发明人：WEYMOUTH-WILSON ALEXANDER; KOMSTA ZOFIA; WALLIS LAURA; EVANS TIMOTHY
权利人:NZP UK LTD
摘要:The invention relates to a process for preparing a compound of general formula (Ia): wherein R2, Y, R4 and R5 are as defined herein, wherein the epoxidation is conducted using an oxidant and methyltrioxorhenium as a catalyst (MeReO3). The invention also relates to certain compounds per se. The compounds are intermediates in the synthesis of synthetic bile acids.

专利号:US-10301350-B2
优先权日:2014-11-19
标题 :6-alkyl-7-hydroxy-4-en-3-one steroids as intermediates for the production of steroidal FXR modulators
发明人：WEYMOUTH-WILSON ALEXANDER; KOMSTA ZOFIA; BOYDELL JAMES; OTTER CARL; WALLIS LAURA; BATCHELOR RHYS
权利人:NZP UK LTD
摘要:The invention relates to compounds of formula (I) and related methods, wherein R 1 , R 2 , Y, R 4 and R 5 are as defined herein. The compounds are intermediates in the synthesis of synthetic bile acids with pharmacological activity. The invention futher provides intermediated in the systhesis of obeticholic acid and its analogues. The invention also provides methods related to the synthesizing of these intermediates and methods of preparing obeticholic acid and obeticholic acid analogues from the compound of the invention.

专利号:US-10597423-B2
优先权日:2014-11-19
标题 :6.alpha.-alkyl-6,7-dione steroids as intermediates for the production of steroidal FXR modulators
发明人：WEYMOUTH-WILSON ALEXANDER; KOMSTA ZOFIA; BOYDELL JAMES; WALLIS LAURA; OTTER CARL; DAVIES IEUAN; CLARKSON ROB
权利人:NZP UK LTD
摘要:Disclosed herein is a process for the preparation of a compound of formula (I) and related methods. The compounds of formula (I) are intermediates in the synthesis of synthetic bile acids and its analogues, and the compounds of formula (I) have pharmacological activity. Methods include the synthesizing of these intermediates, and methods of preparing obeticholic acid and obeticholic acid analogues from the prepared compounds.

专利号:US-10538550-B2
优先权日:2014-11-19
标 题:6.alpha.-alkyl-3,7-dione steroids as intermediates for the production of steroidal FXR modulators
发明人：WEYMOUTH-WILSON ALEXANDER; KOMSTA ZOFIA; BOYDELL JAMES; WALLIS LAURA; BATCHELOR RHYS; OTTER CARL; DAVIES IEUAN
权利人:NZP UK LTD
摘要:The invention relates to compounds of formula (I) wherein R 1 , R 2 , Y 1 , R 4 and R 5 are as defined herein. The compounds are intermediates in the synthesis of synthetic bile acid derivatives with pharmacological activity. The invention further provides methods related to the synthesizing of these intermediates, and methods of preparing obeticholic acid and obeticholic acid analogues from the compounds of the invention.

专利号:US-10131688-B2
优先权日:2014-11-19
标题:5.beta.-6-alkyl-7-hydroxy-3-one steroids as intermediates for the production of steroidal FXR modulators
发明人：WEYMOUTH-WILSON ALEXANDER; KOMSTA ZOFIA; BOYDELL JAMES; WALLIS LAURA; BARTLETT NATHAN; SHELBOURNE MONTSERRAT
权利人:NZP UK LTD
摘要:The invention relates to compounds of formula (I): wherein R 1 , R 2 , Y, R 4 and R 5 are as defined herein. The compounds are intermediates in the synthesis of synthetic bile acids.