CAS: 56-08-6; 2,6-Diaminopyrimidine-4(1H)-Thione
该化合物是三环有机化合物,其特征为:三环结构,含有两个氨基氨基基亚基和硫酮功能组;该化合物一般为白色的脱白晶状固体,在水和酒精中溶解,反映其极性,因氨基氨基亚基亚基亚的出现而反映出其极性;主要用于制药业,特别是用作抗甲状腺剂,因为它能够阻止甲状腺激素合成,阻止将碘纳入甲状腺激素;硫酮组的存在有助于其再活性和生物活动;此外,2,6-Dimino-4(3H)-丙基苯基尼的特性在标准条件下具有中度稳定性,但在接触强酸或基时会退化;其分子结构允许各种相互作用,使其成为医药化学和生物化学的主体.
- 英文名称2,6-Diaminopyrimidine-4(1H)-Thione
- 中文名称2,4-二氨基-6-巯基嘧啶
- IUPAC名称2,6-diaminopyrimidine-4(1H)-thione
- 其它别名2,4-Diamino-6-Mercaptopyrimidine; 2,4-Diaminopyrimidine-6-Thiol; 4(1H)-Pyrimidinethione, 2,6-Diamino- (8Ci,9Ci); 2,4-Diamino-6-Mercaptopyrimidi; 2,6-Diamino-3H-Pyrimidine-4-Thione; 2,6-Diamino-4(3H)-Pyrimidinethione; 2,6-Diaminopyrimidine-4(1H)-Thione
- CAS编号56-08-6
- MFCD编号:MFCD00006099
- EINECS号:622-549-0
- 分子式:C4H6N4S分子量:142.19
- 产品CID: 2304774
- 产品分类医药中间体 → 嘧啶类化合物
物理性质
MSDS等安全信息
- GHS象形图
- GHS符号GHS07;
注释: Exclamation mark - 危险类别急性毒性 类别4(经口)
特定目标器官毒性 - 单次接触 类别3
皮肤腐蚀/刺激 类别2
严重眼刺激 类别2 - 警示词Warning(警告)
- 危险描述H302 |吞咽有害.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激. - 防范说明P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501
欧盟法规
ECHA物质C&L通报上下游产品
CAS号4765-71-3 6-methylsulfany...合成工艺路线路线简述
📜2,4-二氨基-6-氯嘧啶 反应生成 2,4-二氨基-6-巯基嘧啶
参考文献:O.Sup.6-Benzylated Guanine,Guanosine And 2'-Deoxyguanosine Compounds
标题:O.Sup.6-Benzylated Guanine,Guanosine And 2'-Deoxyguanosine Compounds
摘要:O.Sup.6-苄基化鸟嘌呤鸟苷和2'-脱氧鸟嘌呤鸟苷化合物的化学式为 ##str1## 其中z为氢,##str2## 而r为苄基或取代苄基,这些化合物会导致哺乳动物细胞中o.Sup.6-烷基鸟嘌呤-Dna烷基转移酶(agt)活性的耗竭.这些化合物可以被用于治疗多种肿瘤,通过将其注入到宿主体内以减少宿主体内肿瘤细胞中agt的水平,从而增加宿主体对抗肿瘤烷基化剂的反应性,包括氯乙基化剂,如氯乙基亚硝酰脲.
专利信息
专利号:US-6818633-B2
优先权日:2001-06-29
标题:Antiviral compounds and methods for synthesis and therapy
发明人：BALZARINI JAN M R; DE CLERCQ ERIK D A; HOLY ANTONIN
权利人:ACAD OF SCIENCE CZECH REPUBLIC; REGA STICHTING
摘要:Novel compounds are provided having formula (I)whereR1, R2, R3, R4, Z, X and * are defined herein. Also provided are antiviral methods for use and processes for synthesis of the compounds of formula (I).
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
参考标题:The Synthesis Of 7-Deazaguanines As Potential Inhibitors Of Guanosine Triphosphate Cyclohydrolase I作者:Colin L Gibson,Salvatore La Rosa,Kyuji Ohta,Peter H Boyle,Fabien Leurquin,Alexandra Lemaçon,Colin J Suckling |发布日期:2004.1
摘要:Compounds Can Be Prepared. These Methods Supplement Our Previous Work That Established Routes For The Synthesis Of 7- And 8-Substituted 7-Deazaguanines. Emphasis Is Placed On The Properties Of 2-Thioalkyl Pyrimidines As Intermediates Because They Provide The Basis For A Traceless Solid-State Synthesis Of Purines, Pteridines, And Their Analogues. Compounds Prepared Have Been Assessed In A Primary Screen For
合成参考文献
参考DOI号:10.1021/ja01593a062
📝 需求与反馈
尽可能描述清楚需求与问题信息
