CAS: 537-67-7; Diphenylamine Hydrochloride

该化合物是一种有机化合物,其特点是其有矿功能组和芳香结构,似乎是白到白的晶状固体,在水和酒精中可溶解,这是许多氢化氢矿的典型特征;该化合物主要用于各种化学用途,包括作为有机合成的试剂和染料和药品生产中的中间体;其分子结构由一个附于氮原子的联苯组组成,该联苯组又与另一个苯组相连,有助于其稳定性和再活性;盐酸形式表明它是盐酸形成的盐,以水溶液溶解方式增强其溶解性和稳定性;安全考虑包括谨慎处理,因为吸入或浸入可能会对健康造成危害,而且在处理过程中应使用适当的个人保护设备.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

合成工艺路线路线简述

  • 合成目标产物 Diphenylamine Hydrochloride 主要起始原料 Diphenylamine
  • (文献来源)合成步骤主要原料 Diphenylamine
📜二苯胺置于盐酸体系中,用 正己烷,水 作为反应溶剂,化学反应 48.0H,以50%的收率获得产物二苯胺盐酸盐
参考文献:用高活性二苯胺盐将油脂中的脂肪酸酯化为脂肪酸甲酯
标题:用高活性二苯胺盐将油脂中的脂肪酸酯化为脂肪酸甲酯
摘要:发现硫酸二苯胺(dpas)和盐酸二苯胺(dpac1)盐是高活性催化剂,可用于廉价油脂的酯化和大量酯交换为脂肪酸甲酯(fame).在催化量的dpas或dpac1和过量的甲醇存在下,废油脂中的游离脂肪酸以及酰基甘油在1小时内于125oc转化为fame.尽管发现dpas和dpac1催化剂与其母体液态酸(即硫酸和盐酸)具有相似的催化活性,但二苯基铵盐比浓液态酸更易于操作.
DOI:10.1007/s11746-012-2200-1

海关参考信息

专利信息


专利号:US-9693999-B2
优先权日:2011-01-26
标题:Small molecule RNase inhibitors and methods of use
发明人:DUNMAN PAUL M; OLSON PATRICK D; CHILDERS WAYNE
权利人:UNIV ROCHESTER; UNIV NEBRASKA; Temple University—Of the Commonwealth System of Higher Education
摘要:Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease. Also described herein are methods of identifying compounds for treating or preventing a microbial infection.

专利号:WO-2009056955-A1
优先权日:2007-10-30
标题 :Amine-bearing phospholipids (abps), their synthesis and use
发明人:ZUMBUEHL ANDREAS
权利人:UNIV BASEL; ZUMBUEHL ANDREAS
摘要:Disclosed herein are amine-bearing phospholipids (ABP). The ABPs display many properties and functionalities of naturally occurring phospholipids, but also new properties and functionalities, such as the ability to polymerize while maintaining structural integrity, that may supplement or expand the functionalities of naturally occurring phospholipids.

专利号:US-9868747-B2
优先权日:2014-02-18
标题:Marinopyrrole derivatives and methods of making and using same
发明人:LI RONGSHI; SEBTI SAID; LIU YAN; QIN YONG; SONG HAO; CHENG CHUNWEI
权利人:H LEE MOFFITT CANCER CT & RES; CHONGQING ZEIN PHARMACEUTICAL CO LTD
摘要:Marinopyrrole derivatives and methods for their synthesis and use are described herein. Novel cyclic and symmetric marinopyrroles with triazole substituents having antibacterial activity against resistant bacterial strains, such as MRSA are introduced. Also provided are methods of using the compounds for treating or preventing cancer and/or microbial infections.

专利号:US-9907753-B2
优先权日:2010-03-19
标 题 :Lipid vesicle compositions and methods of use
发明人:IRVINE DARRELL J; MOON JAEHYUN
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles may comprise prophylactic, therapeutic and/or diagnostic agents.

专利号:MX-2008001030-A
优先权日:2005-07-26
标 题 :DIAZEPINOQUINOLINAS, SYNTHESIS OF THE SAME AND INTERMEDIARIES FOR THE SAME.

专利号:US-2014315720-A1
优先权日:2012-10-24
标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
发明人:FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
权利人:CELANESE ACETATE LLC
摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.

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主要参考文献

[参考文献]: Safe S, Et Al. Identification Of Toxic Impurities In Commercial Diphenylamine. Bull Environ Contam Toxicol. 1977 Feb;17(2):204-7.

合成参考文献


参考文献:10.1186/s12931-023-02504-4
摘要:Shen K, Zhang M, Zhao R, Li Y, Li C, Hou X, Sun B, Liu B, Xiang M, Lin J. Eosinophil extracellular traps in asthma: implications for pathogenesis and therapy. Respir Res. 2023 Sep 26;24(1):231.
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