CAS: 5111-70-6; 5-Methoxy-1-Indanone

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CAS号5111-69-3 5-甲氧基茚满 | CAS号201230-82-2 carbon monoxide | CAS号40230-92-0 (3-甲氧基苯基乙炔)三甲基硅烷 | CAS号3470-49-3 5-羟基-1-茚酮 | CAS号74-88-4 碘甲烷 | CAS号10516-71-9 3-(3-甲氧基苯基)丙酸 | CAS号591-31-1 3-甲氧基苯甲醛 | CAS号111171-79-0 3-(m-methoxyphe... | CAS号3470-49-3 5-羟基-1-茚酮 | CAS号20920-98-3 6-甲氧基苯并二氢吡喃-2-酮 | CAS号24634-12-6 p-Anisoyl chlor... | CAS号1885-13-8 4-甲氧基邻苯二甲酸 | CAS号68294-03-1 2-(carboxymethy... | CAS号73305-09-6 5-甲氧基-2-茚胺 | CAS号76413-89-3 5-甲氧基-2-茚满酮 | CAS号154932-68-0 5-甲氧基-2-(吡啶-4-甲... | CAS号3469-08-7 5-甲氧基-1H-茚 | CAS号3199-77-7 5-甲氧基-2,3-二氢-1H...

4-Methoxybenzocyclobutenone置于正丁基锂体系中,用 四氢呋喃,乙醚,正己烷,水 作为反应溶剂,化学反应 0.5H,反应生成 5-甲氧基-1-茚酮
参考文献:通过涉及重氮亚甲基化合物净插入的 4π−8π 串联电环反应将苯并环丁烯酮轻松转化为 2,3-苯并二氮杂
标题:通过涉及重氮亚甲基化合物净插入的 4π−8π 串联电环反应将苯并环丁烯酮轻松转化为 2,3-苯并二氮杂
摘要:描述了通过正式插入重氮亚甲基化合物将苯并环丁烯酮有效转化为 2,3-苯二氮卓类的方法.该连续过程包括重氮亚甲基阴离子的亲核加成,氧阴离子通过电环开环反应加速邻醌二甲烷的形成,以及在非常温和的条件下在一锅中进行 8Pi 电环化.中间氧阴离子对有效转化起着重要作用.
DOI:10.1021/ja065277Z

专利信息

专利号:US-6800785-B1
优先权日:2002-10-15
标题:Process for the synthesis of estrogen receptor modulators
发明人：MENG DONGFANG
权利人:MERCK & CO INC
摘要:The present invention relates to processes for the synthesis of intermediates useful for the synthesis of estrogen receptor modulators. The process includes new methods for annelating 5-, 6- and 7-membered cycloalkenones onto an indanone.

专利号:US-2007293706-A1
优先权日:2004-11-01
标 题:Synthesis Of 1,5-Disubstituted-2-Hydroxy-Gibbatetraen-6-Ones
发明人：WILKENING ROBERT R; FRIED AMY; PARKER DANN L JR
权利人:WILKENING ROBERT R; FRIED AMY; PARKER DANN L JR
摘要:1,5-disubstituted-2-hydroxy-gibbatetraen-6-ones are useful as estrogen receptor modulators and as precursors to estrogen receptor modulators. The current invention provides a method for the synthesis of 1,5-disubstituted-2-hydroxy-gibbatetraen-6-ones from simple indanone starting materials via a Robinson-type annulation followed by an internal alkylation reaction. This invention further describes the novel use of a fluoroethyl substituent as a latent alkylating group for an internal cyclization reaction.

专利号:WO-2015131100-A1
优先权日:2014-02-28
标题:Ligand-controlled c(sp3)-h arylation and olefination in synthesis of unnatural chiral alpha amino acids
发明人：YU JIN-QUAN
权利人:SCRIPPS RESEARCH INST
摘要:The use of ligands to tune the reactivity and selectivity of transition metal-catalysts for C(-sp3)-H bond functionalization is a central challenge in synthetic organic chemistry. Herein, we report a rare example of catalyst-controlled C(sp3)-H arylation using pyridine and quinoline derivatives: the former promotes exclusive monoarylation, whereas the latter activates the catalyst further to achieve diarylation. Successive application of these ligands enables the sequential diarylation of a methyl group in an alanine derivative with two different aryl iodides, affording a wide range of β-Ar-p-Ar ' -cc-amino acids with excellent levels of diastereoselectivity (d.r. > 20:1). Both configurations of the β-chiral center can be accessed by choosing the order in which the aryl groups are installed. The use of a quinoline derivative as a ligand also enables C(sp3)-H olefination of a protected alanine.

专利号:US-8633182-B2
优先权日:2012-05-30
标题:Indanyloxyphenylcyclopropanecarboxylic acids
发明人：HAMPRECHT DIETER; FRATTINI SARA; LINGARD IAIN; PETERS STEFAN
权利人:HAMPRECHT DIETER; FRATTINI SARA; LINGARD IAIN; PETERS STEFAN; BOEHRINGER INGELHEIM INT
摘要:The present invention relates to compounds of general formula I, n nwherein the groups R 1 , R 2 , R 3 , m and n are defined as in claim 1 , which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2. Furthermore, the invention relates to novel intermediates, useful for the synthesis of compounds of formula I.

专利号:US-2023002426-A1
优先权日:2019-11-15
标题 :Chiral synthesis of a tertiary alcohol

专利号:AU-2005302235-A1
优先权日:2004-11-01
标 题 :Synthesis of 1,5-disubstituted-2-hydroxy-gibbatetraen-6-ones