CAS: 40731-98-4; 4-Hydroxyindanone

上下游产品

6H4(CH2CH2C(O)O)C6H4(CH2CH2C(O)O) 4-(benzyloxy)-1-indanone 4-carboxy-4,7-epoxy-3a,4,7,7a-tetrahydroinden-1-one inden-1-one 4-methoxylindanone 4-(benzyloxy)-2,3-dihydro-1H-inden-1-one 4-(3-Chlorphenoxy)-1-indanon 4-(3-Trifluormethylphenoxy)-1-indanon

氢化肉桂酸内酯置于aluminum (Iii) Chloride,Potassium Chloride,Sodium Chloride体系中,化学反应生成 4-羟基-1-茚酮
参考文献:Belzutifan 的制造工艺开发,第 1 部分:茚满酮起始材料的简明合成
标题:Belzutifan 的制造工艺开发,第 1 部分:茚满酮起始材料的简明合成
摘要:描述了 Belzutifan (Mk-6482) 茚满酮核心的四步合成.该路线从商品原料二氢香豆素开始,并成功大规模生产茚满酮11,用于合成 Belzutifan,这是一种 Fda 批准的一流疗法,用于治疗某些类型的 Von Hippel-Lindau 患者疾病相关的肿瘤.
DOI:10.1021/acs.Oprd.1C00236

专利信息

专利号:US-2009131688-A1
优先权日:2007-11-21
标 题 :Method for the synthesis of 4-benzofuran-carboxylic acid
发明人：BURGOS ALAIN; MARUANI MARTINE; PERRIN FLORENCE; FREIN STEPHANE
权利人:ZACH SYSTEM
摘要:The invention concerns a novel method for synthesis of 4-benzofuran-carboxylic acid or alkyl ester thereof. n This method is characterized in that a reaction for aromatization of a compound of formula (II) is performed for the synthesis of the compound of formula (I), according to the scheme A2 below: n n n n n n n n n n wherein R independently represents hydrogen or a linear or branched C 1 - 15 alkyl group. n With the invention, it is possible to industrially synthesize 4-benzofuran-carboxylic acid or alkyl ester thereof with good yield and very good purity.

专利号:US-7262326-B2
优先权日:2004-09-08
标 题:Process for the synthesis of indanylamine or aminotetralin derivatives and novel intermediates
发明人：BLANCHET SYLVIE; BLANDINE BERTRAND; BURGOS ALAIN; DERRIEN YVON; MOREAU MARIE-LAURE
权利人:TEVA PHARMA
摘要:A process for preparing indanylamine and aminotetralin derivatives from indanone or tetralone oximes by acylating the oximes with an organic anhydride, followed by catalytic hydrogenation in the presence of an organic anhydride with subsequent hydrolysis is described. The process is commercially feasible providing indanylamine and aminotetralin derivatives in high yield that are useful as intermediates in the production of therapeutically active compounds. Also described are novel intermediates, 1-indanone O-acetyl oximes and 1-tetralone O-acetyl oximes.

专利号:WO-2023061999-A1
优先权日:2021-10-12
标 题 :Process for preparing a phenolic hydrocarbon
发明人：CORNELLA JOSEP; LE VAILLANT FRANCK
权利人:STUDIENGESELLSCHAFT KOHLE GGMBH
摘要:The present invention discloses a distinct mode of action of a nickel catalyst to forge C-0 bonds to unlock the mild utilization of N2O as O-atom transfer reagent in the synthesis of complex phenols from the corresponding aryl halides.

专利号:WO-2009071799-A1
优先权日:2007-11-21
标 题 :Process for the synthesis of 4-benzofurancarboxylic acid

专利号:US-2006052639-A1
优先权日:2004-09-08
标题:Process for the synthesis of indanylamine or aminotetralin derivatives and novel intermediates

专利号:WO-2006029135-A1
优先权日:2004-09-08
标题:Improved process for the synthesis of indanylamine or aminotetralin derivatives and novel intermediates