专利号:US-2007174933-A1 优先权日:2006-01-25 标题 :Altering levels of anti-nutrient factors in plants 发明人:HANNOUFA ABDELALI; SCHAFER ULRIKE A 权利人:HANNOUFA ABDELALI; SCHAFER ULRIKE A 摘要:A method for reducing the level of one or more than one protein in a plant or a tissue within the plant, and plants with reduced levels of target proteins are provided. The method involves introducing a nucleic acid sequence into the plant, where the nucleic acid sequence comprises a regulatory region operatively associated with a silencing nucleotide sequence. The expression of the silencing nucleotide sequence reduces or eliminates the expression of two or more than two enzymes involved in the synthesis of the one or more than one protein. The reduced level of the one or more than one protein may be determine by comparing the level of the one or more than one protein in the plant, or a tissue of the plant, with a level of the one ore more than one protein in a second plant, or the tissue from the second plant, that does not express the nucleic acid sequence. Plants and seeds obtained from plants with reduced levels of target proteins, and reduced anti-nutrient factors are also provided
专利号:US-7705188-B2 优先权日:2002-04-10 标 题:Structural modification of resveratrol: sodium resverastatin phosphate 发明人:PETTIT GEORGE R; GREALISH MATTHEW P 权利人:UNIV ARIZONA 摘要:Described herein are novel compounds having antineoplastic and antimicrobial activity, obtained via structural modifications of resveratrol and combretastatin A-4, methods for synthesis of these compounds, and their use in pharmaceutical composition and for use in the treatment of mammals having cancer. Examples of the novel compounds are: (Z)- and (E)-3,4′,5-trimethoxystilbene (4a, 4b); (Z)- and (E)-3,5-dimethoxy-4′-hydroxystilbene (14c, 14d); (Z)- and (E)-3-hydroxy-4′,5-dimethoxystilbene (14g, 14h); (Z)- and (E)-3,5-dihydroxy-4′-methoxy-stilbene (14k, 14l); sodium resverastatin dibenzyl phosphate ((Z)-3,5-dimethoxy-4-[O-bis(benzyl)phosphoryl]-stilbene) (14m); and sodium resverastatin phosphate (14n).
专利号:US-12180228-B2 优先权日:2019-06-05 标题:Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof 发明人:MOVASSAGHI MOHAMMAD; OLSSON CHASE ROBERT; SCOTT TONY Z; CHEAH JAIME; PAYETTE JOSHUA NATHANIEL 权利人:MASSACHUSETTS INST TECHNOLOGY 摘要:The present disclosure provides, e.g., compounds, compositions, kits, methods of synthesis, and methods of use, involving epipolythiodiketopiperazines and polythiodiketopiperazines.
专利号:CN-114107080-A 优先权日:2021-11-22 标 题:A kind of engineering bacteria, construction and application of microbial synthesis of resveratrol using glucose as substrate
专利号:US-2021329919-A9 优先权日:2019-07-01 标 题:Synthesis and anti-cancer activity of communesin alkaloids 发明人:MOVASSAGHI MOHAMMAD; POMPEO MATTHEW M; CHEAH JAIME 权利人:MASSACHUSETTS INST TECHNOLOGY 摘要:Described herein are compounds of Formula (I):and salts, tautomers, and stereoisomers thereof. Methods of making the compounds, salts, tautomers, and stereoisomers are also described. Further described herein are composition, kits, methods, and uses involving the compounds, salts, tautomers, and stereoisomers. The methods include methods of treating and preventing diseases (e.g., cancers) in subjects (e.g., humans).
专利号:CN-120005740-A 优先权日:2023-11-14 标题:Recombinant microorganism for high-level synthesis of polyphenol compounds and application thereof
1: Zhu F, Dai J, Yan Z, Xu Q, Ma M, Chen N, Liu D, Zang Y. Engineering regioselectivity of glycosyltransferase for efficient polydatin synthesis. Food Chem. 2024 Jul 31;460(Pt 2):140698. doi: 10.1016/j.foodchem.2024.140698. Epub ahead of print. 49(12):3229-3241. Chinese. doi: 10.19540/j.cnki.cjcmm.20240313.302. 261:116510. doi: 10.1016/j.bios.2024.116510. Epub 2024 Jun 17. 226:116373. doi: 10.1016/j.bcp.2024.116373. Epub 2024 Jun 15.
合成参考文献
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