CAS: 24480-45-3; (2S,4As,6As,8Ar,10S,12As,14As,14Br)-10-Hydroxy-2,4A,6A,9,9,12A,14A-Heptamethyl-1,2,3,4,4A,5,6,6A,7,8,8A,9,10,11,12,12A,13,14,14A,14B-Icosahydropicene-2-Carboxylic Acid
该化合物是一种来自各种植物物种,特别是库库尔比切埃家族植物物种的五氯苯酚三叶类化合物,具有显著的防炎,免疫分子和肝脏保护特性,使其成为药理研究感兴趣的对象.该化合物的行动机制包括调节细胞基生产并抑制亲炎途径.还研究其治疗创伤和组织修复的潜力,因为其能够促进凝固合成.其稳定性和相对较低的毒性特征增强了其进一步生物医学应用的适宜性.在高纯度配方中,该化合物可作为分析和实验研究的宝贵参考标准.
- 英文名称(2S,4As,6As,8Ar,10S,12As,14As,14Br)-10-Hydroxy-2,4A,6A,9,9,12A,14A-Heptamethyl-1,2,3,4,4A,5,6,6A,7,8,8A,9,10,11,12,12A,13,14,14A,14B-Icosahydropicene-2-Carboxylic Acid
- 中文名称泻根醇酸
- IUPAC名称(2S,4aS,6aS,8aR,10S,12aS,14aS,14bR)-10-hydroxy-2,4a,6a,9,9,12a,14a-heptamethyl-1,2,3,4,4a,5,6,6a,7,8,8a,9,10,11,12,12a,13,14,14a,14b-icosahydropicene-2-carboxylic acid
- 其它别名3Beta-Hydroxy-D-C-Friedoolean-8-En-29-Oic Acid; ((2R,3R,4R)-3-(Benzoyloxy)-4-Fluoro-4-Methyl-5-Oxotetrahydrofuran-2-yl)Methyl Benzoate; D:C-Friedoolean-8-En-29-Oic Acid, 3-Hydroxy-, (3.Beta.,20.Beta.)-; (2S,4As,6As,8Ar,10S,12As,14As,14Br)-
- CAS编号24480-45-3
- MFCD编号:MFCD20260609
- FDA UNII编号:J7YR6A878I
- 分子式:C30H48O3分子量:456.71
- 产品CID: 1192960
- 产品分类天然产物 → 萜类
物理性质
- 熔点303.5 °C
- 沸点553.3±50.0 °C at 760 mmHg
- 闪点302.5±26.6 °C
- 密度1.1±0.1 g/cm3
- pKa:4.79±0.70(预测)
- PSA:57.53
- LogP:8.99
- 折射率1.557
- 蒸汽压0.0±3.4 mmHg at 25°C
- 溶解性Soluble In Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,Etc.
- 外观形态白色至类白色粉末
- 储存条件2-8°C，干燥环境，密闭
- 产品应用该化合物是在库库尔比塔塞埃植物家族中发现的三叶类动物,有抗炎和抗氧化活动,有D:C-FRIEDOOLEANANE类的单环三叶型三叶色动物,它们与拉格尼亚海藻和CORIA的中间根部分离,并发现存在抗免疫性活动.
MSDS等安全信息
上下游产品
bryononic acid (2R,4aS,6aS,8aR,10S,12aS,14aS,14bR)-methyl 10-hydroxy-2,4a,6a,9,9,12a,14a-heptamethyl-1,2,3,4,4a,5,6,6a,7,8,8a,9,10,11,12,12a,13,14,14a,14b-icosahydropicene-2-carboxylate karounidiol diacetate 7-oxodihydrokarounidiolbryonolol bryononic acid D:C-friedo-olean-8-en-3β-ol Isomultiflorenon合成工艺路线路线简述
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2905122000-异丙醇
2912110000-甲醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Tabata M, Tanaka S, Cho HJ, Uno C, Shimakura J, Ito M, Kamisako W, Honda C. Production of an anti-allergic triterpene bryonolic acid, by plant cell cultures. J Nat Prod. 1993 Feb;56(2):165-74. doi: 10.1021/np200823p. Epub 2012 Feb 16.
3: Kondo T, Inoue M, Mizukami H, Ogihara Y. Cytotoxic activity of bryonolic acid isolated from transformed hairy roots of Trichosanthes kirilowii var. japonica. Biol Pharm Bull. 1995 May;18(5):726-9. doi: 10.1021/np1000076.
5: Tanaka S, Uno C, Akimoto M, Tabata M, Honda C, Kamisako W. Anti-allergic effect of bryonolic acid from Luffa cylindrica cell suspension cultures. Planta Med. 1991 Dec;57(6):527-30. doi: 10.3390/molecules21040418. doi: 10.1007/BF00237132. doi: 10.1055/s-0029-1185455. Epub 2009 Mar 13. doi: 10.1016/j.fct.2009.05.018. Epub 2009 May 19. doi: 10.1021/jo400275p. Epub 2013 Apr 11.
合成参考文献
参考文献:10.5281/zenodo.5794106
摘要:The LOTUS Initiative for Open Natural Products Research: frozen dataset union wikidata (with metadata) | DOI:10.5281/zenodo.5794106
参考文献:10.1016/s0031-9422(00)88975-x
摘要:Hylands PJ, Salama AM. Cucurbitacin S, a new cucurbitacin from Bryonia dioica. Phytochemistry. 1976 Jan;15(4):559–60. doi: 10.1016/s0031-9422(00)88975-x.
参考文献:10.1515/znb-1971-0628
摘要:Tunmann P, Kadry HA. Notizen: Zum Vorkommen der Bryononsäure in der Wurzel von Bryonia dioica Jacq. XII / Occurrence of Bryononic Acid in the Root of Bryonia dioica Jacq. XII. 1971 Jun 01;26(6):620. doi: 10.1515/znb-1971-0628.
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