CAS: 217082-60-5; (Glp1)-Apelin-13
该化合物是原生Apelin-13的经修改的peptide类比,其特点是N终点点的青铜素替代物;这一修改加强了其稳定,防止酶降解,提高其生物利用率并延长生物活动;peptide作为APJ受体的鼓动者,在心血管调节,液态软化和代谢过程中发挥作用;其高度结合性和选择性使其成为研究血管功能,心脏衰竭和代谢紊乱的宝贵工具;[Pyr1-Apelin-13]的合成纯度和持续性能确保可靠的实验再生,支持其在体外和体外研究中的使用.
- 英文名称(Glp1)-Apelin-13
- 中文名称人牛吡啶ApElin-13
- IUPAC名称((S)-5-oxopyrrolidine-2-carbonyl)-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysylglycyl-L-prolyl-L-methionyl-L-prolyl-L-phenylalanine
- 其它别名[PE]APELIN-13, HUMAN, BOVINE; PYR-RPRLSHKGPMPF-OH; PYR-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE; PYR-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE-OH; [PYR1]-APELIN-13; (PYR1)-APELIN-13 (HUMAN, BOVINE); (PYR1)-APELIN-13 (HUMAN, BOVINE, MOUSE, RAT); [PGLU1]APELIN (24-36), HUMAN, BOVINE
- CAS编号217082-60-5
- MFCD编号:MFCD01863147
- 分子式:C69H108N22O16S分子量:1533.83
- 产品CID: 1127792
- 产品分类生物化工 → 多肽
物理性质
- 密度1.5±0.1 g/cm3
- pKa:3.56±0.10(预测)
- PSA:613.26
- LogP:-3.42
- 折射率1.696
- 溶解性Soluble To 1 mg/mL In Sterile Water
- 外观形态白色至类白色粉末
- 储存条件置于阴暗处,密封干燥,冷冻保存, 低于 -20°C
- 产品应用该化合物是一个强力和选择性的内生骨质受体激动剂;它表明在生理条件下将颗粒封装在脂质PEG颗粒中时药物持续和延长释放;在压力过载导致心脏衰竭的老鼠模型中,[PRY1]-PELIN-13纳米载体在防止心脏机能失常方面具有可持续的长期影响;[PRY1]-1-APELIN-1-13(1-5微克)的施用改善了叶质活性,减少了疼痛症状,降低了胆量,降低了胃积大小,并降低了丙型三级;[皮尔1]至13(1-5微克)(1-5微微克)大幅增加了热爪抽取耐受力;5微克剂量[PTY1-肝素-13]还导致爪子抽取临界阈值与脊髓损伤相比,从SCI后第二周对动物进行大幅度的降压.
MSDS等安全信息
上下游产品
CAS号29022-11-5 Fm°C-甘氨酸 | CAS号35661-60-0 Fm°C-L-亮氨酸 | CAS号71989-31-6 Fm°C-L-脯氨酸 | CAS号35661-40-6 Fm°C-L-苯丙氨酸 | CAS号71989-28-1 Fm°C-L-蛋氨酸 | CAS号116611-64-4 Fm°C-L-组氨酸 | CAS号98-79-3 L-焦谷氨酸合成工艺路线路线简述
📜(2R)-2-[(2R)-2-[(2R)-2-Hydroxypropanoyl]Oxypropanoyl]Oxypropanoic Acid置于甲醇,对甲苯磺酸体系中,用 二氯甲烷 用作溶剂,化学反应 2.0H,反应生成人牛吡啶apelin-13
参考文献:Solid-Phase Synthesis Of Enantio-Controlled Lactic Acid Oligomers
标题:Solid-Phase Synthesis Of Enantio-Controlled Lactic Acid Oligomers
摘要:A Synthetic Method For Lactic Acid Oligomers Via Solid-Phase Synthesis Under Mild Reaction Conditions With Up To 99% Yield Is Presented. The Fine Control Of The Chirality On Each Lactic Acid Unit Of The Oligomers Was Easily Achieved By The Substitution Of (R)-Thp-Protected Lactic Acid (R)-2 By (S)-2 Without Alternating The Procedure. The Overall Synthesis Of The Trimer And Tetramer Was Completed In One And Two Days,Respectively. Intramolecular Cyclizations Of Enantio-Controlled Lactic Acids Were Also Attempted Through The Yamaguchi Macrolactonization Or The Mitsunobu Reaction. However,We Were Unable To Isolate Single Cyclic Oligomers But Always Obtained A Mixture Of Cyclic Oligomers. (C) 2011 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Tetasy.2011.08.021
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Sahinturk S, Demirel S, Ozyener F, Isbil N. [Pyr1]apelin-13 relaxes the rat thoracic aorta via APJ, NO, AMPK, and potassium channels. Gen Physiol Biophys. 2021 Sep;40(5):427-434. doi: 10.4149/gpb_20210258.
37:289-98. doi: 10.1016/j.biomaterials.2014.08.045. Epub 2014 Oct 13.
3: Azizi Y, Imani A, Fanaei H, Khamse S, Parvizi MR, Faghihi M. Post-infarct treatment with [Pyr1]apelin-13 exerts anti-remodelling and anti-apoptotic effects in rats' hearts. Kardiol Pol. 2017;75(6):605-613. doi: 10.5603/KP.a2017.0022. Epub 2017 Feb 9.
合成参考文献
参考文献:10.1021/acsmedchemlett.1c00385
摘要:Pi Z, Johnson JA, Meng W, Phillips M, Schumacher WA, Bostwick JS, Gargalovic PS, Onorato JM, Generaux CN, Wang T, He Y, Gordon DA, Wexler RR, Finlay HJ. Identification of 6-Hydroxypyrimidin-4(1H)-one-3-carboxamides as Potent and Orally Active APJ Receptor Agonists. ACS Med. Chem. Lett. 2021 Oct 22;12(11):1766–72. doi: 10.1021/acsmedchemlett.1c00385.
📝 需求与反馈
尽可能描述清楚需求与问题信息
