CAS: 21210-43-5; (S)-Methyl 2-Hydroxy-2-Phenylacetate

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methanol phenylglyoxal hydrate (S)-Mandelic acid S)-1-methyl-2-phenyl-ethyl)-amino]-ethanethiol2-[methyl-((S)-1-methyl-2-phenyl-ethyl)-amino]-ethanethiol diethyl ether (R)-1,1,2-triphenylethane-1,2-diol (S)-1-phenyl-1,2-ethanediol (S)-methyl 2-methoxy-2-phenylacetate

扁桃酸置于daicel Chiralcel Od-3体系中,用 正己烷,异丙醇,仲丁醇 用作溶剂,化学反应生成L-扁桃酸甲酯
参考文献:C1-C4醇中扁桃酸光学拆分中的手性转换:基于非对映异构体盐的x射线晶体结构阐明溶剂效应
标题:C1-C4醇中扁桃酸光学拆分中的手性转换:基于非对映异构体盐的x射线晶体结构阐明溶剂效应
摘要:本文证明了在c1-C4醇中使用(1 R,2 S)-2-氨基-1,2-二苯乙醇(adpe)在扁桃酸(ma)的光学拆分中进行手性转换.从较长的醇溶剂(n-Proh,S-Buoh,I-Buoh和n-Buoh)中将ma盐的非对映混合物重结晶会生成(R)-Ma盐,而(S)-Ma盐则优先由较短的醇溶剂(meoh,Etoh,I-Proh和t-Buoh)沉积.热重分析和11 H NMR光谱表明,所用的所有溶剂均被掺入非对映异构体盐中,并且所掺入的醇的稳定性随其烷基链有效表面积的增加而增加.八个溶剂化非对映异构盐对的x射线晶体结构表明,氢键网络(片状或柱状)的类型和柱状结构的排列受所含醇的长度控制.通过比较两个非对映异构ma盐晶体结构,研究了它们显示手性切换的相对稳定性.
Doi:10.1021/cg500483P

专利信息

专利号:US-11370736-B2
优先权日:2019-04-01
标 题:Synthesis of fluoro hemiacetals via transition metal-catalyzed fluoro ester and carboxamide hydrogenation
发明人：DUB PAVEL A; BATRICE RAMI J; GORDON JOHN C
权利人:TRIAD NAT SECURITY LLC
摘要:This application is directed to use of transition metal-ligand complexes to hydrogenate fluorinated esters and carboxamides into fluorinated hemiacetals. Methods for synthesis of certain ligands are also provided.

专利号:US-5399721-A
优先权日:1990-01-12
标题:Synthesis of optically pure 4-aryl-2-hydroxytetronic acids
发明人：HOPPER ALLEN T; WITIAK DONALD T
权利人:UNIV OHIO STATE RES FOUND
摘要:The present invention relates to a method for synthesis of optically pure stereogenically labile 4-aryl-2-hydroxytetronic acids from an optically pure aldehyde. The invention further relates to the use of such optically pure compounds as potent inhibitors of platelet aggregation by working at the level of cyclooxygenase. the invention further relates to the pharmaceutical use of such compounds in the treatment of coronary artery diseases, especially in the treatment and/or prevention of atherosclerosis.

专利号:US-6384228-B2
优先权日:1998-05-26
标题 :Method for synthesis of halopyridyl-azacyclopentane derivative and intermediate thereof
发明人：NODE MANABU; NAKAMURA DAISAKU; FUJIWARA TOSHIO; ICHIHASHI SHOGO
权利人:NIHON MEDIPHYSICS CO LTD
摘要:The present invention relates to a method for synthesis of an optically active halopyridyl-azacyclo-pentane derivative and the intermediate thereof which comprises preparing an optically active allene-1,3-dicarboxylic acid ester derivative from an optically active acetonedicarboxylic acid ester derivative and then proceeding through a 7-azabicyclo[2.2.1]heptane derivative to obtain the objective product.

专利号:WO-9529150-A1
优先权日:1994-04-21
标 题 :Synthesis of prototypes for renin inhibitors
发明人：HANESSIAN STEPHEN
权利人:CIBA GEIGY AG; HANESSIAN STEPHEN
摘要:Prototype renin inhibitors having general structure (I), where n is 0-3 inclusive, A are either both hydrogen atoms or together are a single carbon-nitrogen bond, R1 is hydrogen, or hydrocarbylcarboxy wherein the hydrocarbyl entity is selected from the group consisting of alkyl of 1 to 6 carbon atoms or aralkyl of 7 to 10 carbon atoms, R2 and R3 or independently alkyl of 1 to 4 carbon atoms, R4 is alkyl of 1 to 6 carbon atoms or a substituent of aliphatic character such as, for example, butyl, 2-morpholinoethyl or 2-carbamoyl-2-methyl-propyl, R5 is selected from aromatics, substitued aromatics and heteroaromatics, substituted or unsubstituted cycloalkyls, cycloalkenes having 3 to 8 carbon atoms, with substituents selected from alkyl, alkoxy of 3 to 10 carbon atoms and alkoxy derivatives such as 3-methoxy-propyloxy, primary and secondary amides, alkyl derivatives, are prepared by novel multistep synthesis. Such compounds are valuable intermediates for the manufacture of pharmaceutical such as Renin inhibitors and HIV-protease inhibitors.

专利号:US-4978744-A
优先权日:1989-01-27
标题:Synthesis of dolastatin 10
发明人：PETTIT GEORGE R; SINGH SHEO B
权利人:UNIV ARIZONA
摘要:A complicated but extremely important scheme of synthesis has been developed for synthesizing, dolaisoleuine, dolaproine, dolaphenine and dolavaline from readily available starting materials such as Z-(S,S)isoleucine, S-phenylalaline, S-phenylalaninol, S-prolinol, S-mandelate, and S-valine. The requisite amino acids have been combined using several peptide coupling procedures to create pharmaceutically pure dolastatin 10.

专利号:US-6469193-B1
优先权日:1999-02-26
标 题 :Efficient synthesis of alkyl carbonates
发明人：JUNG KYUNG WOON
权利人:UNIV SOUTH FLORIDA
摘要:Efficient synthetic methods towards mixed aliphatic carbonates through the three component couplings of aliphatic alcohols, alkyl halides and carbon dioxide in the presence of cesium carbonate and tetrabutylammonium iode (TBAI). Due to their enhanced nucleophilicities, cesium alkoxides are smoothly incorporated into CO 2 , allowing for mild reaction conditions such as ambient temperatures and short reaction durations. Various primary and secondary substrates are compatible under the standard conditions, offering high yields, while chiral templates such as α-hydroxy carbonyls are resistant to racemization.