CAS: 187237-37-2; 2-(Boc-Amino)-5-(Aminomethyl)Pyridine

相似化合物

156973-09-0 260794-33-0 779324-37-7

上下游产品

tert-butyl (5-cyanopyridin-2-yl)carbamate tert-butyl dicarbonatedi-tert-butyl dicarbonate 6-aminonicotinonitrile 2,4-dichlorobenzaldeyhde [5-(3-{4-[6-Ethylamino-5-(2-(piperidin-1-yl)ethylcarbamoyl)pyridin-2-yl]phenyl}-ureidomethyl)pyridin-2-yl]carbamic acid tert-butyl ester tert-butyl 5-((3-(4-(phenylsulfonyl)phenyl)ureido)methyl)pyridin-2-ylcarbamate tert-butyl N-{5-[({[4-(piperidine-1-sulfonyl)phenyl]carbamoyl}amino)methyl]pyridin-2-yl}carbamate

📜2-氨基-5-氰基吡啶置于4-二甲氨基吡啶,氨,氢气,三乙胺体系中,用 甲醇 用作溶剂,化学反应生成2-(Boc-氨基)-5-(胺甲基)吡啶
参考文献: Therapeutic Inhibitory Compounds[fr] Composés Inhibiteurs Thérapeutiques
标题: Therapeutic Inhibitory Compounds[fr] Composés Inhibiteurs Thérapeutiques
摘要:该发明提供了formula I和formula Ii的化合物:A-B-C-D-E-F-G-J (I)和c-D-E-F-G-J (II),其中a,B,C,D,E,F,G和j具有规范中定义的任何值,以及它们的盐.这些化合物对抑制血浆激肽酶和治疗动物中需要抑制血浆激肽酶的疾病或症状是有用的.

专利信息

专利号:US-9994558-B2
优先权日:2013-09-20
标题 :Multicyclic compounds and methods of using same
发明人：BALOGLU ERKAN; SHACHAM SHARON; SENAPEDIS WILLIAM; MCCAULEY DILARA; LANDESMAN YOSEF; GOLAN GALI; KALID ORI; SHECHTER SHARON
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to compounds represented by Structural Formula I: or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders (e.g., PAK-mediated, for example, PAK4-mediated, diseases and disorders).

专利号:US-11279687-B2
优先权日:2010-09-03
标题:Compounds and compositions for the inhibition of NAMPT
发明人：BAIR KENNETH W; BAUMEISTER TIMM R; BUCKMELTER ALEXANDRE J; CLODFELTER KARL H; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG; YUEN PO-WAI
权利人:VALO HEALTH INC; GENENTECH INC
摘要:The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An embodiment of the invention is the provision of a compound of Formula IIIA.

专利号:US-9938258-B2
优先权日:2012-11-29
标 题:Substituted 2,3-dihydrobenzofuranyl compounds and uses thereof
发明人：BALOGLU ERKAN; SHECHTER SHARON; SHACHAM SHARON; MCCAULEY DILARA; SENAPEDIS WILLIAM; GOLAN GALI; KALID ORI
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to substituted 2,3-dihydrobenzofuranyl compounds, and more particularly to a compound represented by Structural Formula I: n nor a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of Structural Formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders.