专利号:US-2023295613-A1 优先权日:2020-02-14 标 题:Long chain carbon and cyclic amino acids substrates for genetic code reprogramming 发明人:JEWETT MICHAEL C; LEE JOONGOO; MOORE JEFFREY S; SCHWARZ KEVIN J 权利人:UNIV NORTHWESTERN; UNIV ILLINOIS 摘要:Abstract: Disclosed are methods, systems, components, and compositions for synthesis of sequence defined polymers. The methods, systems, components, and compositions may be utilized for incorporating novel substrates that include non-standard amino acid monomers and non-amino acid monomers into sequence defined polymers. As disclosed herein, the novel substrates may be utilized for acylation of tRNA via flexizyme catalyzed reactions. The tRNAs thus acylated with the novel substrates may be utilized in synthesis platforms for incorporating the novel substrates into a sequence defined polymer.
专利号:US-11814621-B2 优先权日:2018-06-01 标题 :Expanding the chemical substrates for genetic code reprogramming 发明人:JEWETT MICHAEL CHRISTOPHER; LEE JOONGOO; MOORE JEFFREY S; SCHWIETER KENNETH E; SCHWARZ KEVIN JEROME 权利人:UNIV NORTHWESTERN; UNIV ILLINOIS 摘要:Disclosed are methods, systems, components, and compositions for synthesis of sequence defined polymers. The methods, systems, components, and compositions may be utilized for incorporating novel substrates that include non-standard amino acid monomers and non-amino acid monomers into sequence defined polymers. As disclosed herein, the novel substrates may be utilized for acylation of tRNA via flexizyme catalyzed reactions. The tRNAs thus acylated with the novel substrates may be utilized in synthesis platforms for incorporating the novel substrates into a sequence defined polymer.
专利号:US-2024390383-A1 优先权日:2021-09-28 标题 :Dioxazines and their use in treatment of gba-related diseases 发明人:NEVE SØREN; BROWN WILLIAM DALBY; THIRSTRUP KENNETH 权利人:ZEVRA DENMARK AS 摘要:The present invention relates to dioxazines, their synthesis, and their use for increasing GBA activity and/or levels as well as treatment of GBA-related diseases, such as Parkinson's disease.
专利号:WO-0102375-A1 优先权日:1999-07-01 标 题:Process for synthesizing oxadiazoles 发明人:DENER JEFFREY MARK; LY CUONG QUOC 权利人:AXYS PHARM INC; DENER JEFFREY MARK; LY CUONG QUOC 摘要:The present invention relates to a process for the synthesis of a single as well as large array of oxadiazole based organic compounds. These oxadiazole based organic compounds are represented by compounds of formula (I).
专利号:KR-20220005065-A 优先权日:2019-05-09 标题 :Synthesis of labeled imidazo[1,2-A]pyrimidine
专利号:US-9522901-B2 优先权日:2005-05-26 标题:Compositions and methods including cell death inducers and procaspase activation 发明人:HERGENROTHER PAUL J; PUTT KARSON S; PETERSON QUINN P; FAKO VALERIE 权利人:UNIV ILLINOIS 摘要:Compositions and methods are disclosed in embodiments relating to induction of cell death such as in cancer cells. Compounds and related methods for synthesis and use thereof, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells are disclosed. Compounds are disclosed in connection with modification of procaspases such as procaspase-3. In embodiments, compositions are capable of activation of procaspase-3.