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上下游产品

3-氟-2-羟基吡啶 3-Fluoropyridin-2-Ol 1547-29-1

3-氟-2-羟基吡啶置于溴体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应 12.0H,以62%的收率获得3-氟-5-溴-2-吡啶酮
参考文献:一种取代的噻唑衍生物及其用途
标题:一种取代的噻唑衍生物及其用途
摘要:本发明提供通式(ⅰ)所示化合物,或其立体异构体,药学可接受的盐,溶剂化物,水合物,化学保护的形式或前药,其具有抑制腺苷受体2A(A2A)的作用,可以作为腺苷受体2A(A2A)拮抗剂,用于治疗肿瘤,

专利信息

专利号:US-11286268-B1
优先权日:2019-07-02
标题:EIF4E-inhibiting compounds and methods
发明人：SPERRY SAMUEL; XIANG ALAN X; ERNST JUSTIN T; REICH SIEGFRIED H; SPRENGELER PAUL A; SHAGHAFI MIKE; MICHELS THEO; NILEWSKI CHRISTIAN; TRAN CHINH VIET; PACKARD Garrick Kenneth; GRUBBS ALAN; URKALAN KAVERI; MUKAIYAMA TAKASUKE
权利人:EFFECTOR THERAPEUTICS INC
摘要:The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. n n n n n n n n n n For Formula I compounds X 1 , X 2 , X 3 , X 4 , X 5 , X 6 , Q, L 1 , L 2 , Y, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and rings A, B and C are as defined in the specification. The inventive Formula I compounds are inhibitors of eIF4e and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.