CAS: 136705-64-1; 1,2-Bis((2R,5R)-2,5-Diethylphospholan-1-yl)Benzene

上下游产品

CAS号136705-66-3 (3S,6S)-(+)-3,6-辛二醇 | CAS号80510-04-9 1,2-双(膦酰)苯

📜(3S,6S)-3,6-辛二醇置于ruthenium Trichloride,Sodium Periodate,正丁基锂,氯化亚砜体系中,化学反应 5.5H,反应生成(-)-1,2-双((2R,5R)-2,5-二乙磷酰亚基)苯
参考文献:Burk,Mark J.; Feaster,John E.; Nugent,William A.,Journal Of The American Chemical Society,1993,Vol. 115,# 22,P. 10125-10138
标题:Burk,Mark J.; Feaster,John E.; Nugent,William A.,Journal Of The American Chemical Society,1993,Vol. 115,# 22,P. 10125-10138

专利信息

专利号:US-2016031800-A1
优先权日:2013-03-14
标 题:Synthesis of chiral kynurenine compounds and intermediates
发明人：TRETYAKOV ALEXANDER; DROUET KEITH E; SANDERS WILLIAM
权利人:VISTAGEN THERAPEUTICS INC
摘要:Provided are methods for the synthesis of compounds including chiral kynurenine compounds, intermediates useful for the synthesis thereof, and related compounds. For example, methods are provided for the synthesis of L-4-chlorokynurenine.

专利号:US-12378196-B2
优先权日:2018-12-11
标 题 :Synthesis of (S)-6-hydroxytryptophan and derivatives thereof
发明人：SIMON WERNER; WERNER-SIMON SUSANNE; MüLLER CHRISTOPH
权利人:HEIDELBERG PHARMA RES GMBH
摘要:The present invention relates to novel methods and compounds for synthesizing amanitin derivatives. The invention in particular relates to methods for synthesizing (S)-6-hydroxy-tryptophan derivatives which can be used as building blocks for synthesizing amanitin derivatives or amatoxin drug conjugates. The invention further relates to intermediate compounds of said synthesis pathways for use in amanitin derivative and amatoxin drug conjugate synthesis, and to the use of particular catalysts suited for mediating said synthesis pathways.

专利号:US-6891059-B2
优先权日:2000-01-27
标题:Asymmetric synthesis of pregabalin
发明人：BURK MARK JOSEPH; GOEL OM PRAKASH; HOEKSTRA MARVIN SIMON; MICH THOMAS FREDERICK; MULHERN THOMAS; RAMSDEN JAMES A
权利人:WARNER LAMBERT CO
摘要:This invention provides a method of making (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid (pregabalin) or a salt thereof via an asymmetric hydrogenation synthesis. Pregabalin is useful for the treatment and prevention of seizure disorders, pain, and psychotic disorders. The invention also provides intermediates useful in the production of pregabalin.

专利号:EP-0839142-B1
优先权日:1995-07-13
标题 :A novel asymmetric synthesis of r and s warfarin and its analogs
发明人：LI HUI-YIN; ROBINSON ANDREA JANE
权利人:DU PONT PHARM CO
摘要:The present invention provides a novel process for making compounds of formula (2a or 2b) or pharmaceutically acceptable salts thereof, wherein R1 is selected from the group consisting of phenyl and phenyl substituted with at least one group selected from NO2 and halogen, R2 is H; R3 is selected from the group consisting of C1-4 alkyl, phenyl, and benzyl; and, R4 is selected from the group consisting of H and halogen; which comprises the steps of: a) oxidizing a racemate of formula (2) or a salt thereof to form a dehydro-compound of formula (3), wherein R5 is selected from the group consisting of H, CH3, benzyl, C2-8 acyl, Na, Li and K; and, b) asymmetrically hydrogenating a compound of formula (3) in the presence of a chiral phosphine catalyst to form a compound of formula (2a or 2b).

专利号:US-9365494-B2
优先权日:2008-12-18
标 题 :Process for synthesis of amino-methyl tetralin derivatives
发明人：DURKIN KIERAN; FISHER LAWRENCE EMERSON; MEILI ARTHUR; SCALONE MICHAELANGELO; SHI XIANQING; VITALE JUSTIN
权利人:DURKIN KIERAN; FISHER LAWRENCE EMERSON; MEILI ARTHUR; SCALONE MICHAELANGELO; SHI XIANQING; VITALE JUSTIN; ROCHE PALO ALTO LLC
摘要:Methods for producing a compound of formula k1 or k2 n nby reducing a dihydronapthalene amide compound of formula in n nwith hydrogen gas in the presence of a ruthenium catalyst of formula j1 or j2n nRu(Z) 2 (L)  j1;n nRu(E)(E′)(L)(D)  j2;n nwherein m, n, Ar, Y, R 1 E, E′, D, Z and L are as defined herein.

专利号:US-7476757-B2
优先权日:2005-02-22
标 题:Process for the synthesis of enantiomeric indanylamine derivatives
发明人：BOULTON LEE TERENCE; LENNON IAN CAMPBELL; BAHAR ELIEZER
权利人:TEVA PHARMA
摘要:A process for manufacturing (R)-propynylaminoindans, and alternatively, a process for manufacturing (S)-propynylaminoindans. The chiral propynylaminoindans include alkoxy or alkylcarbamates derivatives. The process comprises transfer or pressure hydrogenation in the presenc of an optically active catalyst to reduce 1-indanones. The chiral product, either (S)- or (R)-indanols undergo nucleophilic substitution to produce the named product. In an additional aspect, the invention relates to novel intermediates and compounds, namely, substituted indanones, substituted (S)-indanols and substituted (R)-indanols.