CAS: 13414-95-4; 6,7-Dihydro-4-Benzo[b]Thiophenone

该化合物是一个环环环化合物,其特点是四位方酮功能组,该结构使其成为有机合成的多用途中间体,特别是在开发药品,农用化学品和特殊化学品方面.其硬性双环框架和反应性碳基组能够选择性地发挥功能,促进复杂的分子结构的建设.该化合物的稳定性和与各种反应条件的兼容性增强了其在多步合成途径中的效用.此外,含有硫的乙型环环会有助于独特的电子和...

英文名称6,7-Dihydro-4-Benzo[b]Thiophenone
中文名称6,7-二氢-4-苯并[b]噻吩酮
IUPAC名称6,7-dihydro-5H-1-benzothiophen-4-one
其它别名4,5,6,7-Tetrahydro-4-benzo[b]thiophenone; 4,5,6,7-Tetrahydro-4-oxothionaphthene; 4,5,6,7-Tetrahydrobenzothiophen-4-one; 4,5,6,7-Tetrahydrothianaphthen-4-one; 4,5,6,7-Tetrahydrothionaphthen-4-one; 4-Oxo-4,5,6,7-tetrahydrobenzo[b]thiophene; 4-Oxo-4,5,6,7-tetrahydrothianaphthene; 4-keto-4,5,6,7-Tetrahydrothianaphthene; 6,7-Dihydro-1-benzo[b]thiophen-4(5H)-one; 6,7-Dihydro-1-benzothiophen-4(5H)-one; 6,7-Dihydro-4-benzo[b]thiophenone; 6,7-Dihydrobenzo[b]thiophen-4(5H)-one; 6,7-Dihydrobenzothiophen-4(5H)-one
CAS编号13414-95-4
MFCD编号:MFCD00005861
EINECS号:236-510-7
FDA UNII编号:TA3LE3X96K
分子式:C8H8OS分子量:152.21
产品CID: 516924
产品分类有机原料→分子砌块→芳杂环类化合物→噻吩类化合物

相似结构搜索
产品信息参考;
InChIKey: GJEKNELSXNSYAQ-UHFFFAOYSA-N
InChI=1S/C8H8OS/c9-7-2-1-3-8-6(7)4-5-10-8/h4-5H,1-3H2
计算化学: 氢键受体数2.0氢键供体数0.0可旋转键数0.0

相似化合物

25074-25-3 74458-89-2 19995-19-8

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别急性毒性类别4(经口)
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2A
警示词Warning(警告)
危险描述H302 |吞咽有害.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
危险等级IRRITANT
危险品标志Xn
安全声明22-24/25-36/37/39-26
危险类别码22
WGK Germany3

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

合成工艺路线路线简述

📜4,5,6,7-Tetrahydro-Benzo[b]Thiophen-4-Ol置于溶剂黄146,1,1'-(Phenyl-λ3-Iodane)Bis(Pyridinium) Trifluoromethanesulfonate体系中,用 1,2-二氯乙烷用作溶剂,化学反应 1.0H,以49%的收率获得4,5,6,7-四氢-4-苯并噻吩
参考文献:N-连接的λ3-碘化物对赤道醇的化学选择性氧化
标题:N-连接的λ3-碘化物对赤道醇的化学选择性氧化
摘要:复杂多元醇中醇的位点选择性和化学选择性官能化仍然是一个艰巨的合成挑战.尽管在氧中心的选择性衍生化方面已取得重大进展,但化学选择性氧化为相应的羰基的进展却很少.在循环系统中,虽然对轴型醇的选择性氧化是众所周知的,但尚未报道互补的赤道选择性过程.本文中,我们报道了氮连接的(双)阳离子λ3-碘(n-Hvis)在醇氧化中的应用以及它们对赤道醇与轴向醇的氧化选择性的空前水平.条件温和,简单的吡啶连接试剂(py-Hvi)可以很容易地从商业phi(oac)2合成,可以分离或原位生成.
Doi:10.1021/acs.Orglett.9B02018

海关参考信息

2912110000-甲醛
2912120000-乙醛
2914190090-其他无环酮
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-8426613-B2
优先权日:2008-12-30
标题:Synthesis of substituted tetrahydroindenyl complexes
发明人：VOSKOBOYNIKOV ALEXANDER Z; IZMER VYATCHESLAV V; KONONOVICH DMITRY S; RAZAVI ABBAS
权利人:VOSKOBOYNIKOV ALEXANDER Z; IZMER VYATCHESLAV V; KONONOVICH DMITRY S; RAZAVI ABBAS; TOTAL PETROCHEMICALS RES FELUY
摘要:This invention relates to the synthesis of substituted tetrahydroindenyls and the use of the synthesized complexes in the homo- and co-polymerization of ethylene and alpha-olefins.

专利号:US-10308663-B2
优先权日:2015-06-16
标题:Inhibitors of PTP4A3 for the treatment of cancer
发明人：LAZO JOHN S; SHARLOW ELIZABETH R; MCQUEENEY KELLEY E; WIPF PETER; SALAMOUN JOSEPH M
权利人:LAZO JOHN S; SHARLOW ELIZABETH R; MCQUEENEY KELLEY E; WIPF PETER; SALAMOUN JOSEPH M; UNIV VIRGINIA PATENT FOUNDATION; UNIV OF PITTSBURGH â€”OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
摘要:The invention provides protein tyrosine phosphatase inhibitor compounds, Their pharmaceutical compositions, uses, and methods of use, such as in the treatment of various cancers, and process for making the compounds. Also disclosed is an improved synthesis of protein tyrosine phosphatase inhibitor and precursor compound thienopyridone (5).

专利号:US-2007275962-A1
优先权日:2003-09-10
标题:Heterobicyclic Compounds as Pharmaceutically Active Agents
发明人：KOUL ANIL; KLEBL BERT; MULLER GERHARD; MISSIO ANDREA; SCHWAB WILFRIED; HAFENBRADL DORIS; NEUMANN LARS; SOMMER MARC-NICOLA; MULLER STEFAN; HOPPE EDMUND; FREISLEBEN ACHIM; BACKES ALEXANDER; HARTUNG CHRISTIAN; FELBER BEATRICE; ZECH BIRGIT; ENGKVIST OLA; KERI GYORGY; ORFI LASZLO; BANHEGYI PETER; GREFF ZOLTAN; HORVATH ZOLTAN; VARGA ZOLTAN; MARKO PETER; PATO JANOS; SZABADKAI ISTVAN; SZEKELYHID ZSOLT; WACZEK FRIGYES
权利人:GPC BIOTECH AG
摘要:Described are heterobicyclic compounds such as 4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid amides, 4,7-dihydro-5H-thieno[2,3-c]thiopyran 3-carboxylic acid amides, 4,7-dihydro-5H-thieno[2,3-c]pyran-3-carboxylic acid amides, or benzo[b]thiophene-3-carboxylic acid amides and pharmaceutically acceptable salts thereof, the use of these derivatives for the prophylaxis and/or treatment of various diseases such as infectious diseases, including mycobacteriainduced infections and opportunistic diseases, prion diseases, immunological diseases, autoimmune diseases, bipolar and clinical disorders, cardiovascular diseases, cell proliferative diseases, diabetes, inflammation, transplant rejections, erectile dysfunction, neurodegenerative diseases and stroke, as well as compositions containing at least one heterobicyclic compound and/or pharmaceutically acceptable salts thereof. Furthermore, reaction procedures for the synthesis of the heterobicyclic compound are disclosed.

专利号:US-2011306741-A1
优先权日:2008-12-30
标题:Synthesis of substituted tetrahydroindenyl complexes

专利号:WO-2010077163-A1
优先权日:2008-12-30
标题 :Synthesis of substituted tetrahydroindenyl complexes, metallocenes produced therefrom and use of the metallocenes in polymerisation processes

专利号:US-9351954-B2
优先权日:2009-12-04
标题:Multicyclic compounds and methods of use thereof
发明人：SHAO LIMING; CAMPBELL JOHN EMMERSON; HEWITT MICHAEL CHARLES; CAMPBELL UNA; HANANIA TALEEN G
权利人:SUNOVION PHARMACEUTICALS INC; PGI DRUG DISCOVERY LLC
摘要:Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. For example, disclosed herein are compounds having formula (IIa) shown below, or a pharmaceutically acceptable salt or stereoisomer thereof, wherein the variables are defined herein. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.