CAS: 119018-30-3; Methyl N-[4-[2-[(4-Ethyl-3-Methyl-5-Oxo-2H-Pyrrole-1-Carbonyl)Amino]Ethyl]Phenyl]Sulfonylcarbamate
该化合物是一种合成有机化合物,其结构复杂,包括一个火花环,一个磺酰集团和一个氨酸盐.该化合物通常用于药物研发,特别是药物设计,因其潜在的生物活动而使用. 全氟辛烷磺酸集团的存在常常提高溶性性和生物利用率,而金星环则能够促进化合物的药理特性.其分子结构表明与生物目标的潜在相互作用,使其对医药化学感兴趣.与许多合成化合物一样,其稳定性,再活性和生物影响将受到各种因素的影响,包括pH,温度和其他化学物种的存在.在与任何化学物质一起与该化合物合作时,安全性和处理预防措施至关重要,对于减轻与接触有关的风险至关重要.
- 英文名称Methyl N-[4-[2-[(4-Ethyl-3-Methyl-5-Oxo-2H-Pyrrole-1-Carbonyl)Amino]Ethyl]Phenyl]Sulfonylcarbamate
- 中文名称格列美脲杂质 C
- IUPAC名称methyl ((4-(2-(3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamido)ethyl)phenyl)sulfonyl)carbamate
- 其它别名GLIMEPIRIDE RELATED COMPOUND C (20 MG) (GLIMEPIRIDE URETHANE); GliMepiride Related CoMpound C; GliMepiride urethane
- CAS编号119018-30-3
- MFCD编号:MFCD08282469
- EINECS号:601-579-8
- FDA UNII编号:A72YB30612
- 分子式:C18H23N3O6S分子量:409.45
- 产品CID: 251126
- 同类组份化合物CAS119018-29-0 (sulfonamide)119018-30-3 (urethane)93479-97-1
- 产品分类分析化学 → 标准品 → 药典标准品和杂质标准品
物理性质
- 熔点178-183°C
- 密度1.3±0.1 g/cm3
- pKa:4.68±0.10(预测)
- PSA:137.24
- LogP:0.97
- 折射率1.569
- 溶解性Chloroform (Slightly, Heated), Methanol (Slightly, Heated)
- 外观形态白色至类白色固体
- 储存条件-20°C 冷藏
- 产品应用该化合物是第三代磺酰胺化合物,它增加了胰岛素从胰腺乙型细胞中释放出来;此外, 滑翔虫会增加细胞内胰岛炎受体的活性; 闪烁会增加卵巢扩散和差异,据认为这与其激活PI3K和AKT路径的能力有关; 此外, 闪光虫会增强内在过氧化过激扩散器激活受体活动; 显微虫也会增加葡萄糖运输1和4的蛋白质表现,并且是一个强大的KIR频道阻塞器.
MSDS等安全信息
欧盟法规
REACH注册C&L通报REACH预注册合成工艺路线路线简述
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2902600000-乙苯
2912110000-甲醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-2007082943-A1
优先权日:2005-04-01
标 题:Process for preparation of substantially pure glimepiride
发明人：KADAM SURESH M; TARUR VENKATASUBRAMANIAN R; NAIK SANJAY J; GAVHANE SACHIN B
权利人:KADAM SURESH M; TARUR VENKATASUBRAMANIAN R; NAIK SANJAY J; GAVHANE SACHIN B
摘要:The present invention discloses a novel process for purification of trans-4-methyl cyclohexylamine HCl and 4[-2-(3-Ethyl-4-methyl-2-carbonyl pyrrolidine amido) ethyl] benzene sulfonamide used in the synthesis of 3-Ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[(trans-4-methyl cyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo-1H-pyrrole-1-carboxamide (I), popularly known as Glimepiride. The present invention also discloses a novel purification of Glimepiride usingS methanolic ammonia and glacial acetic acid to obtain highly pure Glimepiride Form I (I) having the undesired cis isomer below 0.15%. Glimepiride (I) is useful in the treatment of diabetes mellitus.
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主要参考文献
1: Rizvi SM, Shaikh S, Naaz D, Shakil S, Ahmad A, Haneef M, Abuzenadah AM. Kinetics and Molecular Docking Study of an Anti-diabetic Drug Glimepiride as Acetylcholinesterase Inhibitor: Implication for Alzheimer's Disease-Diabetes Dual Therapy. Neurochem Res. 2016 Feb 17. [Epub ahead of print] doi: 10.1016/j.neuropharm.2015.09.030. Epub 2015 Oct 8. doi: 10.1055/s-0035-1549993. Epub 2015 May 26. doi: 10.1016/j.ijpharm.2015.11.007. Epub 2015 Nov 12. doi: 10.2337/dc14-1625. Epub 2015 Jun 18. doi: 10.1016/j.jval.2015.09.2101. Epub 2015 Oct 20. Open-label randomized non-inferiority trial of a fixed-dose combination of glimepiride and atorvastatin for the treatment of people whose Type 2 diabetes is uncontrolled on metformin. Diabet Med. 2015 Oct 20. doi: 10.1111/dme.13003. [Epub ahead of print]
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