CAS: 108831-68-1; 4-Chloro-5,6-Dimethylthieno[2,3-D]Pyrimidine

相似化合物

43088-67-1 42518-42-3 83548-58-7

上下游产品

5,6-dimethyl-1H-thieno[2,3-d]pyrimidin-4-one pyrimidin-4(3H)-one5,6-dimethylthieno2,3-dpyrimidin-4(3H)-one 2-amino-4,5-dimethyl-3-thiophenecarboxylic acid ethyl ester H-thieno[2,3-d]pyrimidin-4-one5,6-dimethyl-3H-thieno[2,3-d]pyrimidin-4-one N-(1-(cyclohexylmethyl)piperidin-4-yl)-5,6-dimethylthieno[2,3-d]pyrimidin-4-amine 3-(5,6-dimethyl-thieno[2,3-d]pyrimidin-4-yloxy)-2-phenyl-[1,8]naphthyridine 2-(5,6-dimethylthieno[2,3-d]pyrimidin-4-ylamino)-3-methylbutyric acid 2-(5,6-dimethylthieno[2,3-d]pyrimidin-4-ylamino)ethanol

📜5,6-二甲基噻吩[2,3-D]嘧啶-4(3H)-酮置于三氯氧磷体系中,化学反应生成4-氯-5,6-二甲基噻吩[2,3-D]嘧啶
参考文献:4-取代的噻吩并[2,3-D]嘧啶类作为有效的抗菌剂:合理的设计,微波辅助合成,生物学评估和分子对接研究
标题:4-取代的噻吩并[2,3-D]嘧啶类作为有效的抗菌剂:合理的设计,微波辅助合成,生物学评估和分子对接研究
摘要:设计,合成4-取代的噻吩并[2,3-D ]嘧啶并评估其抗菌活性.对接研究表明,强效化合物对细菌二氢蝶呤合酶具有抑制活性.因此,还确定了其与dhps酶的结合亲和力.
Doi:10.1111/cbdd.13028

专利信息

专利号:US-7030240-B2
优先权日:2003-03-31
标 题:Piperidinylamino-thieno[2,3-d] pyrimidine compounds
发明人：DHANOA DALE S; BECKER OREN; NOIMAN SILVIA; REDDY SEKAR A; CHERUKU SRINIVASA RAO; MELE NDEZ ROSA E; SHARADENDU ANURAG; CHEN DONGLI; MARANTZ YAEL; SHACHEM SHARON; HEIFETZ ALEXANDER; INBAL BOAZ; KESAVAN VENKITASAMY; BAR-HAIM SHAY
权利人:PREDIX PHARMACEUTICALS HOLDING
摘要:The invention relates to 5-HT receptor antagonists. Novel piperidinylamino-thieno[2,3-d] pyrimidine compounds represented by Formula I, and synthesis and uses thereof for treating diseases mediated directly or indirectly by 5-HT receptors, are disclosed. Such conditions include central nervous system disorders such as anxiety, depression, schizophrenia, neural injury, stroke, and migraine. Methods of preparation and novel intermediates and pharmaceutical salts thereof are also included.