专利号:US-8647848-B2 优先权日:2008-06-13 标题:Enzymatic synthesis of sphingolipids 发明人:HOLLMANN FRANK; THUM OLIVER; TOELLE CHRISTOPH; PROVINZANO ANGELO; KOREVAAR CORNELIS GERRIT NIJS 权利人:HOLLMANN FRANK; THUM OLIVER; TOELLE CHRISTOPH; PROVINZANO ANGELO; KOREVAAR CORNELIS GERRIT NIJS; EVONIK GOLDSCHMIDT GMBH 摘要:The invention relates to the enzymatic synthesis of sphingolipids and compositions that contain sphingolipids from lysosphingolipids and carbonic esters, and to cosmetic, dermatological or pharmaceutical formulations containing said sphingolipids or compositions.
专利号:US-4582804-A 优先权日:1985-07-09 标 题 :Microbiological synthesis of hydroxy-fatty acids and keto-fatty acids 发明人:LITCHFIELD JOHN H; PIERCE GEORGE E 权利人:LITCHFIELD JOHN H; PIERCE GEORGE E 摘要:The synthesis of hydroxy-fatty acids and keto-fatty acids from unsaturated fatty acids by Rhodococcus rhodochrous is disclosed.
专利号:US-2016237050-A1 优先权日:2013-09-23 标题 :Synthesis process for diacetyl epoxy glyceryl oleate 发明人:LI DAOBIN; CAI QIHONG; LIN CHAOJIE 权利人:GUANGZHOU HAIRMA CHEMICAL (GZ) LTD 摘要:The present invention relates to a process for the synthesis of diacetyl epoxy glyceryl oleate, comprising the steps of: a). esterification of glycerol and oleic acid at 115-190° C. for 1.5-4.5 hours in the presence of an esterification catalyst to obtain glyceryl monooleate; b). acetylation of glyceryl monooleate and an acetylating reagent at 90-160° C. for 2-10 hours in the presence of an acetylation catalyst to obtain diacetyl glyceryl oleate; c). epoxidation of diacetyl glyceryl oleate and hydrogen peroxide at 60-80° C. for 2-4 hours in the presence of an epoxidation catalyst and a weak acid to obtain diacetyl epoxy glyceryl oleate. The prepared diacetyl epoxy glyceryl oleate can be used as plasticizer in plastics, with the advantages of improved stability, good flowability, and high compatibility with plastics.
专利号:US-4983750-A 优先权日:1988-08-06 标题 :Phosphobetaines, methods for their synthesis and their use especially for industrial purposes 发明人:GIERSBERG JOACHIM; KOLLMEIER HANS-JOACHIM 权利人:GOLDSCHMIDT AG TH 摘要:Phosphobetaines of the general formula ##STR1## are disclosed in which R 1 is an alkyl group with 1 to 20 carbon atoms, optionally substituted with OH groups, or the ##STR2## group, in which R 6 is a divalent alkylene group with 1 to 10 carbon atoms, optionally substituted with OH group, n R 2 is a divalent hydrocarbon group with 2 to 10 carbon atoms, the chain of which may be interrupted by one or more nitrogen atoms, n R 1 , R 5 are the same or different and represent alkyl or benzyl groups and n R 4 is an alkyl group with 1 to 4 carbon atoms. n Also disclosed is the synthesis of these compounds and their use as surface active substances, preferably for the treatment of polar surfaces in the industrial area.
专利号:US-6869973-B2 优先权日:2000-06-22 标题:Nitrosated and nitrosylated taxanes, compositions and methods of use 发明人:GARVEY DAVID S; LETTS L GORDON; LIN CHIA-EN; RICHARDSON STEWART K; WANG TIANSHENG 权利人:NITROMED INC 摘要:The present invention describes novel nitrosated and/or nitrosylated taxanes, and novel compositions comprising at least one nitrosated and/or nitrosylated taxane, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The present invention also provides novel compositions comprising at least one taxane and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The compounds and compositions of the present invention can also be bound to a matrix. The present invention also provides methods for treating or preventing cardiovascular diseases and disorders, autoimmune diseases, pathological conditions resulting from abnormal cell proliferation, polycystic kidney disease, inflammatory disease, preserving organs and/or tissues or to inhibit wound contraction, particularly the prophylactic and/or therapeutic treatment of restenosis, by administering nitrosated and/or nitrosylated taxane or parent taxanes in combination with nitric oxide donors that are capable of releasing nitric oxide or indirectly delivering or transferring nitric oxide to targeted sites under physiological conditions.
专利号:US-2003203915-A1 优先权日:2002-04-05 标题 :Nitric oxide donors, compositions and methods of use related applications 发明人:FANG XINQIN; GARVEY DAVID S; GASTON RICKY D; LIN CHIA-EN; RANATUNGA RAMANI R; RICHARDSON STEWART K; WANG TIANSHENG; WANG WEIHENG; WEY SHIOW-JYI 权利人:FANG XINQIN; GARVEY DAVID S; GASTON RICKY D; LIN CHIA-EN; RANATUNGA RAMANI R; RICHARDSON STEWART K; WANG TIANSHENG; WANG WEIHENG; WEY SHIOW-JYI 摘要:The invention describes novel nitric oxide donors and novel compositions comprising at least one nitric oxide donor. The invention also provides novel compositions comprising at least one nitric oxide donor, and, optionally, at least one therapeutic agent. The compounds and compositions of the invention can also be bound to a matrix. The invention also provides methods for treating cardiovascular diseases, for the inhibition of platelet aggregation and platelet adhesion caused by the exposure of blood to a medical device, for treating pathological conditions resulting from abnormal cell proliferation; transplantation rejections, autoimmune, inflammatory, proliferative, hyperproliferative, vascular diseases; for reducing scar tissue or for inhibiting wound contraction, particularly the prophylactic and/or therapeutic treatment of restenosis by administering the nitric oxide donor optionally in combination with at least one therapeutic agent. The invention also provides methods for treating inflammation, pain, fever, gastrointestinal disorders, respiratory disorders and sexual dysfunctions. The nitric oxide donors donate, transfer or release nitric oxide, and/or elevate endogenous levels of endothelium-derived relaxing factor, and/or stimulate endogenous synthesis of nitric oxide and/or are substrates for nitric oxide synthase and are capable of releasing nitric oxide or indirectly delivering or transferring nitric oxide to targeted sites under physiological conditions. The therapeutic agent can optionally be substituted with at least one NO and/or NO 2 group (i.e., nitrosylated and/or nitrosated). The invention also provides novel compositions and kits comprising at least one nitric oxide donor and/or at least one therapeutic agent.
[参考文献]: Gordon R, Et Al. Aggregation Of 12-Hydroxystearic Acid And Its Lithium Salt In Hexane: Molecular Dynamics Simulations. J Phys Chem B. 2016;120(29):7164-7173. [参考文献]: Giovanna Lollo, Et Al. Development Of Multifunctional Lipid Nanocapsules For The Co-Delivery Of Paclitaxel And Cpg-Odn In The Treatment Of Glioblastoma. Int J Pharm. 2015 Nov 30;495(2):972-80. [参考文献]: Tamer H Hassan, Et Al. Novel Semisolid Snedds Based On Peg-30-Di-(Polyhydroxystearate): Progesterone Incorporation And In Vitro Digestion. Int J Pharm. 2015;486(1-2):77-87.
合成参考文献
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