CAS: 106-14-9; 12-Hydroxyoctadecanoic Acid

该化合物是一种具有18碳链和氢氧基的氢氧化脂肪衍生物,在第12个位置有一个18碳链和一个氢氧基组;该化合物因其极地氢氧基组和非极地碳氢化合物尾的两栖特性,对工业和研究应用感兴趣;它是合成特殊表面活性剂,润滑剂和生物聚合物的前体;该氢氧基组的存在增强了其再活性,有利于修改定制的功能材料;其生物降解性和从天然脂肪酸中可再生来源进一步有助于其在可持续化学应用中的用途;该化合物的典型特征是其熔点,溶性特征和纯度,这对制剂的性能至关重要.

结构式图片

相似化合物

141-23-1 638-26-6 2726-73-0

欧盟法规

REACH注册ECHA物质ECHA物质C&L通报REACH预注册

上下游产品

CAS号925-44-0 12-氧代十八酸 | CAS号6114-39-2 (R)-12-Hydroxys... | CAS号74815-67-1 12-羟基硬脂酸乙酯 | CAS号41989-07-5 12-羟基油酸甲酯 | CAS号141-22-0 蓖麻油酸 | CAS号5810-18-4 11-氰基-1-十一酸 | CAS号44767-62-6 1-己基氯化镁 | CAS号36840-82-1 12-oxo-°Ctadeca... | CAS号66003-63-2 十二烷二酸一乙酯 | CAS号106-15-0 羟硬脂酰胺 MEA | CAS号143-25-9 反式十八烷酸 | CAS号20602-43-1 13,26-dihexyl-1... | CAS号673-02-9 12-hydroxystear... | CAS号29710-25-6 12-羟基硬脂酸-2-乙基己酯 | CAS号111-14-8 庚酸 | CAS号1852-04-6 十一烷二酸 | CAS号693-23-2 十二烷二酸 | CAS号142-62-1 正己酸 | CAS号123-99-9 壬二酸

合成工艺路线路线简述

  • 合成目标产物 12-Hydroxystearic Acid 主要起始原料 Cyclododecanol
  • (文献来源)合成步骤主要原料 Cyclododecanol
12-羟基硬脂酸甲酯置于氢氧化钾体系中,化学反应生成12-羟基硬脂酸
参考文献:强碱中的有机反应-Iii:酮酸和羟基酸的裂变
标题:强碱中的有机反应-Iii:酮酸和羟基酸的裂变
摘要:用合适的脂肪酸衍生物进行的研究澄清了醇和酮在浓碱中的许多反应.
Doi:10.1016/0040-4020(60)80033-6

海关参考信息

专利信息


专利号:US-8647848-B2
优先权日:2008-06-13
标题:Enzymatic synthesis of sphingolipids
发明人:HOLLMANN FRANK; THUM OLIVER; TOELLE CHRISTOPH; PROVINZANO ANGELO; KOREVAAR CORNELIS GERRIT NIJS
权利人:HOLLMANN FRANK; THUM OLIVER; TOELLE CHRISTOPH; PROVINZANO ANGELO; KOREVAAR CORNELIS GERRIT NIJS; EVONIK GOLDSCHMIDT GMBH
摘要:The invention relates to the enzymatic synthesis of sphingolipids and compositions that contain sphingolipids from lysosphingolipids and carbonic esters, and to cosmetic, dermatological or pharmaceutical formulations containing said sphingolipids or compositions.

专利号:US-4582804-A
优先权日:1985-07-09
标 题 :Microbiological synthesis of hydroxy-fatty acids and keto-fatty acids
发明人:LITCHFIELD JOHN H; PIERCE GEORGE E
权利人:LITCHFIELD JOHN H; PIERCE GEORGE E
摘要:The synthesis of hydroxy-fatty acids and keto-fatty acids from unsaturated fatty acids by Rhodococcus rhodochrous is disclosed.

专利号:US-2016237050-A1
优先权日:2013-09-23
标题 :Synthesis process for diacetyl epoxy glyceryl oleate
发明人:LI DAOBIN; CAI QIHONG; LIN CHAOJIE
权利人:GUANGZHOU HAIRMA CHEMICAL (GZ) LTD
摘要:The present invention relates to a process for the synthesis of diacetyl epoxy glyceryl oleate, comprising the steps of: a). esterification of glycerol and oleic acid at 115-190° C. for 1.5-4.5 hours in the presence of an esterification catalyst to obtain glyceryl monooleate; b). acetylation of glyceryl monooleate and an acetylating reagent at 90-160° C. for 2-10 hours in the presence of an acetylation catalyst to obtain diacetyl glyceryl oleate; c). epoxidation of diacetyl glyceryl oleate and hydrogen peroxide at 60-80° C. for 2-4 hours in the presence of an epoxidation catalyst and a weak acid to obtain diacetyl epoxy glyceryl oleate. The prepared diacetyl epoxy glyceryl oleate can be used as plasticizer in plastics, with the advantages of improved stability, good flowability, and high compatibility with plastics.

专利号:US-4983750-A
优先权日:1988-08-06
标题 :Phosphobetaines, methods for their synthesis and their use especially for industrial purposes
发明人:GIERSBERG JOACHIM; KOLLMEIER HANS-JOACHIM
权利人:GOLDSCHMIDT AG TH
摘要:Phosphobetaines of the general formula ##STR1## are disclosed in which R 1 is an alkyl group with 1 to 20 carbon atoms, optionally substituted with OH groups, or the ##STR2## group, in which R 6 is a divalent alkylene group with 1 to 10 carbon atoms, optionally substituted with OH group, n R 2 is a divalent hydrocarbon group with 2 to 10 carbon atoms, the chain of which may be interrupted by one or more nitrogen atoms, n R 1 , R 5 are the same or different and represent alkyl or benzyl groups and n R 4 is an alkyl group with 1 to 4 carbon atoms. n Also disclosed is the synthesis of these compounds and their use as surface active substances, preferably for the treatment of polar surfaces in the industrial area.

专利号:US-6869973-B2
优先权日:2000-06-22
标题:Nitrosated and nitrosylated taxanes, compositions and methods of use
发明人:GARVEY DAVID S; LETTS L GORDON; LIN CHIA-EN; RICHARDSON STEWART K; WANG TIANSHENG
权利人:NITROMED INC
摘要:The present invention describes novel nitrosated and/or nitrosylated taxanes, and novel compositions comprising at least one nitrosated and/or nitrosylated taxane, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The present invention also provides novel compositions comprising at least one taxane and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The compounds and compositions of the present invention can also be bound to a matrix. The present invention also provides methods for treating or preventing cardiovascular diseases and disorders, autoimmune diseases, pathological conditions resulting from abnormal cell proliferation, polycystic kidney disease, inflammatory disease, preserving organs and/or tissues or to inhibit wound contraction, particularly the prophylactic and/or therapeutic treatment of restenosis, by administering nitrosated and/or nitrosylated taxane or parent taxanes in combination with nitric oxide donors that are capable of releasing nitric oxide or indirectly delivering or transferring nitric oxide to targeted sites under physiological conditions.

专利号:US-2003203915-A1
优先权日:2002-04-05
标题 :Nitric oxide donors, compositions and methods of use related applications
发明人:FANG XINQIN; GARVEY DAVID S; GASTON RICKY D; LIN CHIA-EN; RANATUNGA RAMANI R; RICHARDSON STEWART K; WANG TIANSHENG; WANG WEIHENG; WEY SHIOW-JYI
权利人:FANG XINQIN; GARVEY DAVID S; GASTON RICKY D; LIN CHIA-EN; RANATUNGA RAMANI R; RICHARDSON STEWART K; WANG TIANSHENG; WANG WEIHENG; WEY SHIOW-JYI
摘要:The invention describes novel nitric oxide donors and novel compositions comprising at least one nitric oxide donor. The invention also provides novel compositions comprising at least one nitric oxide donor, and, optionally, at least one therapeutic agent. The compounds and compositions of the invention can also be bound to a matrix. The invention also provides methods for treating cardiovascular diseases, for the inhibition of platelet aggregation and platelet adhesion caused by the exposure of blood to a medical device, for treating pathological conditions resulting from abnormal cell proliferation; transplantation rejections, autoimmune, inflammatory, proliferative, hyperproliferative, vascular diseases; for reducing scar tissue or for inhibiting wound contraction, particularly the prophylactic and/or therapeutic treatment of restenosis by administering the nitric oxide donor optionally in combination with at least one therapeutic agent. The invention also provides methods for treating inflammation, pain, fever, gastrointestinal disorders, respiratory disorders and sexual dysfunctions. The nitric oxide donors donate, transfer or release nitric oxide, and/or elevate endogenous levels of endothelium-derived relaxing factor, and/or stimulate endogenous synthesis of nitric oxide and/or are substrates for nitric oxide synthase and are capable of releasing nitric oxide or indirectly delivering or transferring nitric oxide to targeted sites under physiological conditions. The therapeutic agent can optionally be substituted with at least one NO and/or NO 2 group (i.e., nitrosylated and/or nitrosated). The invention also provides novel compositions and kits comprising at least one nitric oxide donor and/or at least one therapeutic agent.
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主要参考文献

[参考文献]: Gordon R, Et Al. Aggregation Of 12-Hydroxystearic Acid And Its Lithium Salt In Hexane: Molecular Dynamics Simulations. J Phys Chem B. 2016;120(29):7164-7173.
[参考文献]: Giovanna Lollo, Et Al. Development Of Multifunctional Lipid Nanocapsules For The Co-Delivery Of Paclitaxel And Cpg-Odn In The Treatment Of Glioblastoma. Int J Pharm. 2015 Nov 30;495(2):972-80.
[参考文献]: Tamer H Hassan, Et Al. Novel Semisolid Snedds Based On Peg-30-Di-(Polyhydroxystearate): Progesterone Incorporation And In Vitro Digestion. Int J Pharm. 2015;486(1-2):77-87.

合成参考文献


摘要:US EPA; Inventory Update Reporting (IUR). Non-confidential 2006 IUR Records by Chemical, including Manufacturing, Processing and Use Information. Washington, DC: U.S. Environmental Protection Agency. Available from, as of May 24, 2010:
摘要:Lyman WJ et al; Handbook of Chemical Property Estimation Methods. Washington, DC: Amer Chem Soc pp. 7-4, 7-5, 8-12 (1990)
摘要:US EPA; Non-confidential Production Volume Information Submitted by Companies for Chemicals Under the 1986-2002 Inventory Update Rule (IUR). Octadecanoic acid, 12-hydroxy- (106-14-9). Available from, as of August 5, 2010:
摘要:Lide, D.R. CRC Handbook of Chemistry and Physics 88TH Edition 2007-2008. CRC Press, Taylor & Francis, Boca Raton, FL 2007, p. 3-296
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