CAS: 103724-99-8; 2-Bromo-5-Chloro-1,3-Dimethylbenzene

相似化合物

14495-51-3 85072-44-2 425394-71-4

上下游产品

CAS号24596-18-7 4-氯-2,6-二甲基苯胺 | CAS号75-25-2 三溴甲烷 | CAS号103724-96-5 4,4-Dichloro-1,...

4-氯-2,6-二甲基苯胺置于氢溴酸,Sodium Nitrite,Ferrous(II) Sulfate Heptahydrate体系中,用 水 用作溶剂,化学反应 2.09H,以91%的收率获得4-氯-2,6-甲基溴代苯
参考文献:Process For Preparing Chloro-And Bromoaromatics
标题:Process For Preparing Chloro-And Bromoaromatics
摘要:本发明涉及一种制备公式(II)的氯代或溴代芳烃的新工艺,该工艺通过在水合盐酸或水合氢溴酸存在下,使用硝酸钠或硝酸钾对公式(i)进行重氮化,然后与铁(II)或铁(III)化合物反应,可选地在额外的氯化氢或溴化氢或碱金属或碱土金属氯化物或溴化物的存在下进行.

专利信息

专利号:US-12150934-B2
优先权日:2016-11-30
标 题 :Methods of using substituted pyrazole and pyrazole compounds and for treatment of hyperproliferative diseases
发明人：SIDDIQUI ARSHAD M; CIBLAT STEPHANE; CONSTANTINEAU-FORGET LEA; GRAND-MAITRE CHANTAL; GUO XIANGYU; SRIVASTAVA SANJAY; SHIPPS GERALD W; COOPER ALAN B; OZA VIBHA; KOSTURA MATTHEW W; LUTHER MICHAEL; LEVINE JEDD
权利人:BANTAM PHARMACEUTICAL LLC
摘要:Disclosed are methods of treating hyperproliferative disorders such as cancer, methods of arresting the cell cycle in cancer cells, methods of inhibiting glutathione synthesis in cancer cells, and associated compounds for use and uses in medicaments. In certain embodiments, the methods, uses and compounds are provided with reference to compounds of the structural formula (I), in which X1, X2, Z1, Z2, the ring system denoted by “aâ€?, R1, L1, L2, Q, L3, R3, L4, R4, L5, and R5 are as described herein. In certain embodiments, compounds disclosed herein are especially active against cancers having a mutant KRAS gene.